Patents by Inventor Kazushi Shigemasa

Kazushi Shigemasa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Extracellular serine protease
    Patent number: 8609819
    Abstract: The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention. Also provided is a TADG-14 protein variant that has a potential role for detecting and targeting of ovarian carcinomas.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: December 17, 2013
    Assignee: Board of Trutees of the University of Arkansas
    Inventors: Timothy J O'Brien, Lowell J Underwood, John Beard, Kazushi Shigemasa
  • Extracellular Serine Protease
    Publication number: 20120264123
    Abstract: The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention. Also provided is a TADG-14 protein variant that has a potential role for detecting and targeting of ovarian carcinomas.
    Type: Application
    Filed: June 1, 2012
    Publication date: October 18, 2012
    Applicant: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
    Inventors: Timothy J. O'Brien, Lowell J. Underwood, John Beard, Kazushi Shigemasa
  • Extracellular serine protease
    Patent number: 8216794
    Abstract: The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention. Also provided is a TADG-14 protein variant that has a potential role for detecting and targeting of ovarian carcinomas.
    Type: Grant
    Filed: June 4, 2010
    Date of Patent: July 10, 2012
    Assignee: Board of Trustees of the University of Arkansas
    Inventors: Timothy J. O'Brien, Lowell J. Underwood, John Beard, Kazushi Shigemasa
  • Methods for the early diagnosis of ovarian cancer
    Publication number: 20110086056
    Abstract: The present invention discloses the protease hepsin is specifically over-expressed in ovarian and other malignancies. A number of hepsin peptides can induce immune responses to hepsin, thereby demonstrating the potential of these peptides in monitoring and the development of immunotherapies for ovarian and other malignancies. There is also provided a hepsin protein variant that is useful as a marker for ovarian cancer cells, prostate cancer cells or kidney cancer cells.
    Type: Application
    Filed: September 3, 2010
    Publication date: April 14, 2011
    Inventors: Timothy J. O'Brien, Martin J. Cannon, Alessandro Santin, John Beard, Kazushi Shigemasa
  • Extracellular serine protease
    Publication number: 20100291124
    Abstract: The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention. Also provided is a TADG-14 protein variant that has a potential role for detecting and targeting of ovarian carcinomas.
    Type: Application
    Filed: June 4, 2010
    Publication date: November 18, 2010
    Inventors: Timothy J. O'Brien, Lowell J. Underwood, John Beard, Kazushi Shigemasa
  • Methods for the early diagnosis of ovarian cancer
    Patent number: 7795211
    Abstract: The present invention discloses the protease hepsin is specifically over-expressed in ovarian and other malignancies. A number of hepsin peptides can induce immune responses to hepsin, thereby demonstrating the potential of these peptides in monitoring and the development of immunotherapies for ovarian and other malignancies. There is also provided a hepsin protein variant that is useful as a marker for ovarian cancer cells, prostate cancer cells or kidney cancer cells.
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: September 14, 2010
    Assignee: Board of Trustees of the University of Arkansas
    Inventors: Timothy J. O'Brien, Martin J. Cannon, Alessandro Santin, John Beard, Kazushi Shigemasa
  • Extracellular serine protease
    Patent number: 7732163
    Abstract: The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention. Also provided is a TADG-14 protein variant that has a potential role for detecting and targeting of ovarian carcinomas.
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: June 8, 2010
    Assignee: Board of Trustees of The University of Arkansas
    Inventors: Timothy J. O'Brien, Lowell J. Underwood, John Beard, Kazushi Shigemasa
  • Uses of antileukoprotease in carcinoma
    Publication number: 20090142328
    Abstract: The present invention provides a method of detecting/monitoring tumor growth and progression in a tissue by measuring the level of antileukoprotease. Also provided is a method of treating an individual having a tumor by administering antileukoprotease to inhibit the activity of stratum corneum chymotryptic enzyme. Specifically, the tumor is an ovarian carcinoma.
    Type: Application
    Filed: October 3, 2007
    Publication date: June 4, 2009
    Inventors: Timothy J. O'Brien, Lowell J. Underwood, Hirotoshi Tanimoto, Kazushi Shigemasa
  • Extracellular serine protease
    Publication number: 20060205054
    Abstract: The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention. Also provided is a TADG-14 protein variant that has a potential role for detecting and targeting of ovarian carcinomas.
    Type: Application
    Filed: August 29, 2003
    Publication date: September 14, 2006
    Inventors: Timothy O'Brien, Lowell Underwood, John Beard, Kazushi Shigemasa
  • Methods for the early diagnosis of ovarian cancer
    Publication number: 20040166117
    Abstract: The present invention discloses the protease hepsin is specifically over-expressed in ovarian and other malignancies. A number of hepsin peptides can induce immune responses to hepsin, thereby demonstrating the potential of these peptides in monitoring and the development of immunotherapies for ovarian and other malignancies. There is also provided a hepsin protein variant that is useful as a marker for ovarian cancer cells, prostate cancer cells or kidney cancer cells.
    Type: Application
    Filed: August 29, 2003
    Publication date: August 26, 2004
    Inventors: Timothy J. O'Brien, Martin J. Cannon, Alessandro Santin, John Beard, Kazushi Shigemasa
  • Uses of antileukoprotease in carcinoma
    Publication number: 20030170759
    Abstract: The present invention provides a method of detecting/monitoring tumor growth and progression in a tissue by measuring the level of antileukoprotease. Also provided is a method of treating an individual having a tumor by administering antileukoprotease to inhibit the activity of stratum corneum chymotryptic enzyme. Specifically, the tumor is an ovarian carcinoma.
    Type: Application
    Filed: April 8, 2003
    Publication date: September 11, 2003
    Applicant: Board of Trustees of University of Arkansas
    Inventors: Timothy J. O' Brien, Lowell J. Underwood, Hirotoshi Tanimoto, Kazushi Shigemasa
  • Uses of antileukoprotease in carcinoma
    Patent number: 6602674
    Abstract: The present invention provides a method of detecting/monitoring tumor growth and progression in a tissue by measuring the level of antileukoprotease. Also provided is a method of treating an individual having a tumor by administering antileukoprotease to inhibit the activity of stratum corneum chymotryptic enzyme. Specifically, the tumor is an ovarian carcinoma.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: August 5, 2003
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Timothy J. O'Brien, Lowell J. Underwood, Hirotoshi Tanimoto, Kazushi Shigemasa
  • Tumor antigen-derived gene 16 (TADG-16): a novel extracellular serine protease and uses thereof
    Publication number: 20030027144
    Abstract: The present invention provides a DNA encoding a TADG-16 protein selected from the group consisting of: (a) isolated DNA which encodes a TADG-16 protein; (b) isolated DNA which hybridizes to isolated DNA of (a) above and which encodes a TADG-16 protein; and (c) isolated DNA differing from the isolated DNAs of (a) and (b) above in codon sequence due to the degeneracy of the genetic code, and which encodes a TADG-16 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell.
    Type: Application
    Filed: July 17, 2001
    Publication date: February 6, 2003
    Applicant: The University of Arkansas for Medical Sciences
    Inventors: Lowell J. Underwood, Timothy J. O'Brien, Kazushi Shigemasa