Abstract: The present technique relates to a surgery system, a surgery control device, a control method, and a program that allow a practitioner to easily operate a device during surgery. A surgery region is captured to acquire a surgery image that is an image of the surgery region, and a display image is output on the basis of the surgery image. With at least one of a surgical instrument and a hand reflected on the surgery image as an operation body, a predetermined instruction operation by the operation body is accepted on the basis of an image of the operation body in the surgery image. The present technique is applied to an endoscope system and a microscope surgery system.