Patents by Inventor Kazutoyo Abe
Kazutoyo Abe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8252781Abstract: [Object] It is to provide a novel compound useful for preventing and/or treating diseases that involves 11?-hydroxysteroid dehydrogenase 1 (in particular diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome). [Means to Solve the Object] A 1,2-diazetidin-3-one derivative represented by the following general formula (1) or salt thereof, or their solvate.Type: GrantFiled: October 28, 2009Date of Patent: August 28, 2012Assignee: Kowa Company, Ltd.Inventors: Hisashi Nakashima, Takaaki Araki, Takahisa Ogamino, Noriaki Gomi, Yasushi Kaneko, Kazutoyo Abe, Tadaaki Ohgiya
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Patent number: 8236789Abstract: It is to provide a novel compound useful for preventing and/or treating diseases that involves 11?-hydroxysteroid dehydrogenase 1, particularly diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome. It is an 1-adamantyl azetidin-2-one derivative represented by the following general formula (1) or salt thereof, or their solvate.Type: GrantFiled: August 28, 2009Date of Patent: August 7, 2012Assignee: Kowa Company, Ltd.Inventors: Hisashi Nakashima, Takahiro Mori, Ryoko Mori, legal representative, Takaaki Araki, Takahisa Ogamino, Kazutoyo Abe, Tadaaki Ohgiya
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Publication number: 20100144694Abstract: [Object] It is to provide a novel compound useful for preventing and/or treating diseases that involves 11?-hydroxysteroid dehydrogenase 1 (in particular diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome). [Means to Solve the Object] A 1,2-diazetidin-3-one derivative represented by the following general formula (1) or salt thereof, or their solvate.Type: ApplicationFiled: October 28, 2009Publication date: June 10, 2010Applicant: KOWA COMPANY, LTD.Inventors: Hisashi Nakashima, Takaaki Araki, Takahisa Ogamino, Noriaki Gomi, Yasushi Kaneko, Kazutoyo Abe, Tadaaki Ohgiya
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Publication number: 20100075943Abstract: It is to provide a novel compound useful for preventing and/or treating diseases that involves 11?-hydroxysteroid dehydrogenase 1, particularly diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome. It is an 1-adamantyl azetidin-2-one derivative represented by the following general formula (1) or salt thereof, or their solvate.Type: ApplicationFiled: August 28, 2009Publication date: March 25, 2010Applicant: KOWA COMPANY, LTD.,Inventors: Hisashi Nakashima, Takahiro Mori, Takaaki Araki, Takahisa Ogamino, Kazutoyo Abe, Tadaaki Ohgiya, Ryoko Mori
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Publication number: 20100022572Abstract: It is to provide a novel compound useful for preventing and/or treating diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome. A spiro compound represented by the following general formula (1) or salt thereof, or their solvate.Type: ApplicationFiled: July 16, 2009Publication date: January 28, 2010Applicant: KOWA COMPANY, LTD.Inventors: Hisashi Nakashima, Takahisa Ogamino, Takaaki Araki, Noriaki Gomi, Yasushi Kaneko, Kazutoyo Abe, Tadaaki Ohgiya, Kimiyuki Shibuya
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Publication number: 20080306102Abstract: A Spiro oxindole compound represented by formula (1) of the present invention or salt thereof, or their solvate shows a superior inhibitory effect of 11?-hydroxysteroid dehydrogenasel, and is useful as an agent for preventing or treating a disease that involves 11?-hydroxysteroid dehydrogenasel (in particular, diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome).Type: ApplicationFiled: May 16, 2008Publication date: December 11, 2008Applicant: KOWA CO., LTD.Inventors: Hisashi NAKASHIMA, Takaaki ARAKI, Takahisa OGAMINO, Yasushi KANEKO, Kazutoyo ABE, Kimiyuki SHIBUYA, Tadaaki OHGIYA
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Patent number: 7301033Abstract: The present invention provides a compound selectively activating PPAR?, which is useful as a medicament. The present invention is specifically directed to a benzoic acid derivative represented by the following general formula (1): wherein A represents an oxygen atom, a nitrogen atom, or a sulfur atom; R represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a cycloalkyl-alkyl group, an aryl group, an aryl-alkyl group an aryl-oxy-alkyl group, a pyridyl-alkyl group, an alkoxycarbonyl-alkyl group, or a carboxy-alkyl group; X represents an oxygen atom, an NH group, or an S(O)n group (wherein n represents an integer of 0, 1, or 2); and m represents an integer from 2 to 8; or a salt thereof. The present invention also provides a medicament comprising the benzoic acid derivative or the salt thereof as an active ingredient.Type: GrantFiled: January 20, 2006Date of Patent: November 27, 2007Assignee: Kowa Co., Ltd.Inventors: Yukiyoshi Yamazaki, Tsutomu Toma, Masahiro Nishikawa, Hajime Yamada, Hidefumi Ozawa, Ayumu Okuda, Kazutoyo Abe
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Patent number: 7183295Abstract: A compound represented by the following formula (1): (wherein each of R1 and R2, which may be identical to or different from each other, represents a hydrogen atom, a methyl group, or an ethyl group; each of R3a, R3b, R4a, and R4b, which may be identical to or different from each other, represents a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a C1-4 alkyl group, a trifluoromethyl group, a C1-4 alkoxy group, a C1-4 alkylcarbonyloxy group, a di-C1-4 alkylamino group, a C1-4 alkylsulfonyloxy group, a C1-4 alkylsulfonyl group, a C1-4 alkylsulfinyl group, or a C1-4 alkylthio group, or R3a and R3b, or R4a and R4b may be linked together to form an alkylenedioxy group; X represents an oxygen atom, a sulfur atom, or N—R5 (R5 represents a hydrogen atom, a C1-4 alkyl group, a C1-4 alkylsulfonyl group, or a C1-4 alkyloxycarbonyl group); Y represents an oxygen atom, S(O)l (l is a number of 0 to 2), a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, or an aminosuType: GrantFiled: April 20, 2006Date of Patent: February 27, 2007Assignee: Kowa Co., Ltd.Inventors: Yukiyoshi Yamazaki, Tsutomu Toma, Masahiro Nishikawa, Hidefumi Ozawa, Ayumu Okuda, Takaaki Araki, Kazutoyo Abe, Soichi Oda
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Patent number: 7109226Abstract: A compound represented by the following formula (1): Or a salt thereof; and therapeutic durgs containing the compound. The compound selectively activates PPAR?.Type: GrantFiled: September 3, 2004Date of Patent: September 19, 2006Assignee: Kowa Co., Ltd.Inventors: Yukiyoshi Yamazaki, Tsutomu Toma, Masahiro Nishikawa, Hidefumi Ozawa, Ayumu Okuda, Takaaki Araki, Kazutoyo Abe, Soichi Oda
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Publication number: 20060189667Abstract: A compound represented by the following formula (1): (wherein each of R1 and R2, which may be identical to or different from each other, represents a hydrogen atom, a methyl group, or an ethyl group; each of R3a, R3b, R4a, and R4b, which may be identical to or different from each other, represents a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a C1-4 alkyl group, a trifluoromethyl group, a C1-4 alkoxy group, a C1-4 alkylcarbonyloxy group, a di-C1-4 alkylamino group, a C1-4 alkylsulfonyloxy group, a C1-4 alkylsulfonyl group, a C1-4 alkylsulfinyl group, or a C1-4 alkylthio group, or R3a and R3b, or R4a and R4b may be linked together to form an alkylenedioxy group; X represents an oxygen atom, a sulfur atom, or N—R5 (R5 represents a hydrogen atom, a C1-4 alkyl group, a C1-4 alkylsulfonyl group, or a C1-4 alkyloxycarbonyl group); Y represents an oxygen atom, S(O)l (l is a number of 0 to 2), a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, or an aminosType: ApplicationFiled: April 20, 2006Publication date: August 24, 2006Applicant: KOWA CO., LTD.Inventors: Yukiyoshi Yamazaki, Tsutomu Toma, Masahiro Nishikawa, Hidefumi Ozawa, Ayumu Okuda, Takaaki Araki, Kazutoyo Abe, Soichi Oda
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Publication number: 20060167058Abstract: The present invention provides a compound selectively activating PPAR?, which is useful as a medicament. The present invention is specifically directed to a benzoic acid derivative represented by the following general formula (1): wherein A represents an oxygen atom, a nitrogen atom, or a sulfur atom; R represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a cycloalkyl-alkyl group, an aryl group, an aryl-alkyl group an aryl-oxy-alkyl group, a pyridyl-alkyl group, an alkoxycarbonyl-alkyl group, or a carboxy-alkyl group; X represents an oxygen atom, an NH group, or an S(O)n group (wherein n represents an integer of 0, 1, or 2); and m represents an integer from 2 to 8; or a salt thereof. The present invention also provides a medicament comprising the benzoic acid derivative or the salt thereof as an active ingredient.Type: ApplicationFiled: January 20, 2006Publication date: July 27, 2006Applicant: Kowa Co., Ltd.Inventors: Yukiyoshi Yamazaki, Tsutomu Toma, Masahiro Nishikawa, Hajime Yamada, Hidefumi Ozawa, Ayumu Okuda, Kazutoyo Abe
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Publication number: 20050101636Abstract: A compound represented by the following formula (1): Or a salt thereof; and therapeutic durgs containing the compound. The compound selectively activates PPAR?.Type: ApplicationFiled: September 3, 2004Publication date: May 12, 2005Applicant: KOWA CO., LTD.Inventors: Yukiyoshi Yamazaki, Tsutomu Toma, Masahiro Nishikawa, Hidefumi Ozawa, Ayumu Okuda, Takaaki Araki, Kazutoyo Abe, Soichi Oda
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Patent number: 6653334Abstract: The present invention is directed to a benzoxazole compound represented by the following formula (1): (wherein R1 represents an alkyl group, a C6-10 aryl-C1-8 alkyl group, etc.; each of R2 and R3, which are identical to or different from each other, represents a hydrogen atom, a methyl group, or an ethyl group; and n represents a number of 1 to 3) or a salt thereof and to a pharmaceutical compound containing the same. These compounds electively activate PPAR&agr;.Type: GrantFiled: December 27, 2002Date of Patent: November 25, 2003Assignee: Kowa Co., Ltd.Inventors: Yukiyoshi Yamazaki, Tsutomu Toma, Masahiro Nishikawa, Hidefumi Ozawa, Ayumu Okuda, Kazutoyo Abe, Soichi Oda