Patents by Inventor Kazuya Machida
Kazuya Machida has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11929214Abstract: Provided is a hybrid electrolytic capacitor having large capacitance, low ESR, and superior high-frequency characteristics and high-temperature endurance.Type: GrantFiled: December 15, 2020Date of Patent: March 12, 2024Assignee: NIPPON CHEMI-CON CORPORATIONInventors: Kazuya Koseki, Kazuhiro Nagahara, Kenji Machida
-
Patent number: 11464956Abstract: A microneedle device of the present invention comprises a substrate, microneedles disposed on the substrate, and a coating layer formed on the microneedles, wherein a length of the microneedles is 300 to 500 ?m, the microneedles are disposed on the substrate at a density of 28 to 80 needles/cm2, and the coating layer comprises a biologically active substance. The microneedle device allows the skin irritation caused by administration of an agent to be reduced.Type: GrantFiled: February 20, 2018Date of Patent: October 11, 2022Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Kazuya Machida, Shinpei Nishimura, Seiji Tokumoto
-
Publication number: 20210080465Abstract: The present disclosure provides methods and compositions for prognosing Chronic Lymphocytic Leukemia (CLL) or monitoring CLL therapy in a subject, by contacting a blood sample from a subject having CLL with one or more tyrosine phosphorylation (pTyr) probes to promote binding of tyrosine phosphorylated proteins in the blood sample to the one or more pTyr probes to generate pTyr probe-protein complexes; and detecting an amount of pTyr probe-protein complexes in the blood sample; wherein an amount of pTyr probe-protein complexes in the blood sample is compared to a control to indicate expected progression of CLL, or therapeutic efficacy of CLL therapy in the subject.Type: ApplicationFiled: September 17, 2020Publication date: March 18, 2021Inventors: Bruce Mayer, Kazuya Machida, Adam Lafontaine
-
Publication number: 20190374761Abstract: A microneedle device of the present invention comprises a substrate, microneedles disposed on the substrate, and a coating layer formed on the microneedles, wherein a length of the microneedles is 300 to 500 ?m, the microneedles are disposed on the substrate at a density of 28 to 80 needles/cm2, and the coating layer comprises a biologically active substance. The microneedle device allows the skin irritation caused by administration of an agent to be reduced.Type: ApplicationFiled: February 20, 2018Publication date: December 12, 2019Inventors: Kazuya MACHIDA, Shinpei NISHIMURA, Seiji TOKUMOTO
-
Patent number: 9993549Abstract: An adjuvant composition of the present invention contains lauryl alcohol and propylene glycol. Contents of the lauryl alcohol and the propylene glycol are 0.5 to 25% by mass and 8.0 to 99.5% by mass, relative to the total mass of the adjuvant composition, respectively. The lauryl alcohol is dissolved, and the adjuvant composition is used for transdermal or transmucosal administration.Type: GrantFiled: October 30, 2014Date of Patent: June 12, 2018Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Seiji Tokumoto, Kazuya Machida, Nao Kurokawa, Rie Namiki
-
Patent number: 9849170Abstract: Disclosed is a microneedle coating composition comprising a Japanese encephalitis vaccine antigen, a basic amino acid, and an acid, wherein the mole number of the acid for one mole of the basic amino acid is larger than 1/(N+1) and less than 2, where N represents the valence of the acid.Type: GrantFiled: February 12, 2014Date of Patent: December 26, 2017Assignees: HISAMITSU PHARMACEUTICAL CO., INC., THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTEInventors: Kazuya Machida, Seiji Tokumoto, Kazuyoshi Kaminaka, Yuji Ishikawa
-
Patent number: 9775799Abstract: Disclosed is a microneedle coating composition comprising a physiologically active substance (excluding Japanese encephalitis vaccine antigen), a basic amino acid, and an acid, wherein the mole number of the acid for one mole of the basic amino acid is larger than 1/(N+1) and less than 2, where N represents the valence of the acid.Type: GrantFiled: February 12, 2014Date of Patent: October 3, 2017Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Takuya Sugahara, Kazuya Machida
-
Publication number: 20160263215Abstract: An adjuvant composition of the present invention contains lauryl alcohol and propylene glycol. Contents of the lauryl alcohol and the propylene glycol are 0.5 to 25% by mass and 8.0 to 99.5% by mass, relative to the total mass of the adjuvant composition, respectively. The lauryl alcohol is dissolved, and the adjuvant composition is used for transdermal or transmucosal administration.Type: ApplicationFiled: October 30, 2014Publication date: September 15, 2016Inventors: Seiji TOKUMOTO, Kazuya MACHIDA, Nao KUROKAWA, Rie NAMIKI
-
Publication number: 20160000898Abstract: Disclosed is a microneedle coating composition comprising a Japanese encephalitis vaccine antigen, a basic amino acid, and an acid, wherein the mole number of the acid for one mole of the basic amino acid is larger than 1/(N+1) and less than 2, where N represents the valence of the acid.Type: ApplicationFiled: February 12, 2014Publication date: January 7, 2016Inventors: Kazuya MACHIDA, Seiji TOKUMOTO, Kazuyoshi KAMINAKA, Yuji ISHIKAWA
-
Publication number: 20150374620Abstract: Disclosed is a microneedle coating composition comprising a physiologically active substance (excluding Japanese encephalitis vaccine antigen), a basic amino acid, and an acid, wherein the mole number of the acid for one mole of the basic amino acid is larger than 1/(N+1) and less than 2, where N represents the valence of the acid.Type: ApplicationFiled: February 12, 2014Publication date: December 31, 2015Inventors: Takuya SUGAHARA, Kazuya MACHIDA
-
Patent number: 8911422Abstract: An object of the present invention is to efficiently inject a drug (physiologically active substance). Therefore, a micro-needle device 1 comprises a base plate 2 and a micro-needle 3 installed on the base plate 2. A coating agent containing the physiologically active substance is coated at least at a part of the micro-needle 3, and a coating range thereof is 100 to 230 ?m including the top of the micro-needle 3. A load due to the energy of 0.2 to 0.7 J/cm2 is applied to the micro-needle device 1 which is in contact with the skin.Type: GrantFiled: February 24, 2011Date of Patent: December 16, 2014Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Tetsuji Kuwahara, Seiji Tokumoto, Kazuya Machida
-
Publication number: 20130226098Abstract: An applicator 10 for applying a microneedle to a skin includes a tubular housing 11, a piston 20 which transmits a biasing force of a spring 40 to the microneedle, fixation means (a claw receiving portion 16 and claw portions 22a) for fixing the piston 20 against the biasing force of the spring 40 in the housing 11, and a cap 30 provided near a first end of the housing 11. A projecting portion 31 for releasing the piston 20 fixed by the fixation means is provided at a surface of the cap 30 facing the piston 20. The cap 30 is provided to be freely movable in an extending direction of the housing 11 such that the projecting portion 31 can contact the fixation means when the piston 20 is fixed by the fixation means.Type: ApplicationFiled: October 6, 2011Publication date: August 29, 2013Applicant: Hisamitsu Pharmaceutical Co., Inc.Inventors: Seiji Tokumoto, Makoto Ogura, Kazuya Machida
-
Patent number: 8519773Abstract: A method for switching between first and second voltages is provided. Initially, a first voltage is provided from a first input terminal to an output terminal through a first MOS transistor, and the first MOS transistor is deactivated. A back-gate of a second MOS transistor is shorted to the output terminal in response to the deactivation of the first MOS transistor and after a settling interval, and the second MOS transistor is activated while its back-gate is shorted to the terminal so as to provide a second voltage from a second input terminal to the output terminal.Type: GrantFiled: June 17, 2011Date of Patent: August 27, 2013Assignee: Texas Instruments IncorporatedInventors: Hiroshi Watanabe, Hiroaki Kojima, Kazuya Machida
-
Publication number: 20120330250Abstract: An object of the present invention is to efficiently inject a drug (physiologically active substance). Therefore, a micro-needle device 1 comprises a base plate 2 and a micro-needle 3 installed on the base plate 2. A coating agent containing the physiologically active substance is coated at least at a part of the micro-needle 3, and a coating range thereof is 100 to 230 ?m including the top of the micro-needle 3. A load due to the energy of 0.2 to 0.7 J/cm2 is applied to the micro-needle device 1 which is in contact with the skin.Type: ApplicationFiled: February 24, 2011Publication date: December 27, 2012Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Tetsuji Kuwahara, Seiji Tokumoto, Kazuya Machida
-
Publication number: 20120319762Abstract: A method for switching between first and second voltages is provided. Initially, a first voltage is provided from a first input terminal to an output terminal through a first MOS transistor, and the first MOS transistor is deactivated. A back-gate of a second MOS transistor is shorted to the output terminal in response to the deactivation of the first MOS transistor and after a settling interval, and the second MOS transistor is activated while its back-gate is shorted to the terminal so as to provide a second voltage from a second input terminal to the output terminal.Type: ApplicationFiled: June 17, 2011Publication date: December 20, 2012Applicant: Texas Instruments IncorporatedInventors: Hiroshi Watanabe, Hiroaki Kojima, Kazuya Machida
-
Patent number: D699344Type: GrantFiled: April 19, 2011Date of Patent: February 11, 2014Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Seiji Tokumoto, Makoto Ogura, Kazuya Machida
-
Patent number: D754333Type: GrantFiled: October 17, 2013Date of Patent: April 19, 2016Assignee: Hisamitsu Pharmaceutical Co., Inc.Inventors: Seiji Tokumoto, Makoto Ogura, Kazuya Machida