Abstract: This application describes novel therapeutic strategies for treating patients with hypertriglyceridemia and/or chylomicronemia based on the presence of GPIHBP1 autoantibodies. It was unexpectedly found that autoantibodies to GPIHBP1, a GPI anchored protein of capillary endothelial cells that shuttles lipoprotein lipase to its site of action in the capillary lumen, were found to be present in patients with hypertriglyceridemia, and that the autoantibodies blocked the binding of lipoprotein lipase (LPL) to GPIHBP1. Patients having hypertriglyceridemia and/or chylomicronemia and also having GPIHBP1 autoantibodies may be treated with a therapeutically effective amount of an immunosuppressive treatment and/or GPIHBP1 activator.

Abstract: The current disclosure relates to a novel therapeutic strategy for patients with hypertriglyceridemia and/or chylomicronemia, wherein the patient is determined to have autoantibodies to GPIHBP1. It was unexpectedly found that autoantibodies to GPIHBP1, a GPI anchored protein of capillary endothelial cells that shuttles lipoprotein lipase to its site of action in the capillary lumen, were found to be present in patients with hypertriglyceridemia, and that the autoantibodies blocked the binding of lipoprotein lipase (LPL) to GPIHBP1. Accordingly, aspects of the disclosure relate to a method for treating hypertriglyceridemia and/or chylomicronemia in a patient comprising administering a therapeutically effective amount of an immunosuppressive treatment and/or GPIHBP1 activator to the patient; wherein the patient has been determined to have GPIHBP1 autoantibodies.

Abstract: The present invention monitors images stored in a cloud storage and displays, in a list form distinctively, images stored only locally; images stored only in the cloud storage; the images that are stored in the cloud storage, that correspond to the images stored locally, and that are updated; and the images that are stored in the cloud storage, that correspond to the images stored locally, and that are not updated.

Abstract: In the chroma killer detection for detecting the abnormality of the burst signal, in addition to the circuits (1004, 1005, 1006) for detecting the states of the components of the burst signal, which circuits are for selecting the cos ? data of the burst signal, circuits (1050, 1051, 1052) for detecting the states of the R-Y components, which circuits are for selecting sin ? data are employed for chroma killer detection. Thereby, it is possible to enhance the detection precision of the abnormality states of the burst signal and the precision for discrimination of the broadcasting system.

Abstract: A band-pass filter (131), which extracts a frequency component of a teletext reference signal from a digital input signal obtained by digitizing a composite signal, is provided in a frequency characteristic enhancement circuit (130). A determination circuit (145), which determines a state of the composite signal in accordance with maximum and minimum values of an output of the frequency characteristic enhancement circuit (130) during the period of the teletext reference signal and in accordance with maximum and minimum values of the output of the frequency characteristic enhancement circuit (130) during the period of time between a current horizontal synchronization interval and a next horizontal synchronization interval, is provided in a slicing circuit (140).

Abstract: In the chroma killer detection for detecting the abnormality of the burst signal, in addition to the circuits (1004, 1005, 1006) for detecting the states of the components of the burst signal, which circuits are for selecting the cos ? data of the burst signal, circuits (1050, 1051, 1052) for detecting the states of the R-Y components, which circuits are for selecting sin ? data are employed for chroma killer detection. Thereby, it is possible to enhance the detection precision of the abnormality states of the burst signal and the precision for discrimination of the broadcasting system.

Abstract: An NTSC system chrominance signal demodulation apparatus is provided with a clock timing change circuit for burst-locking an input signal under the state where the phase is shifted by 90 degrees for every line, and phase axis rotation circuits for performing phase axis rotation, thereby to enable conversion of the phase axis of the burst signal. Therefore, demodulation of a PAL system chrominance signal can be carried out as well as demodulation of an NTSC system chrominance signal, and thereby demodulation of chrominance signals can be carried out using a common device regardless of the broadcast systems such as NTSC and PAL. Further, demodulation of chrominance signals can be carried out even under adverse conditions such as weak electric field or level compression of the burst signal.

Abstract: A color demodulation circuit that can complement an unstable state of an output from an ACC circuit and can obtain stable color-difference outputs, regardless of a burst signal in a chrominance carrier signal. Normally, a selector connects an output from a first multiplier that controls an amplitude of an output from a band-pass filter using an output from the ACC circuit, to a color-difference output demodulation circuit. However, during a period in which there are abrupt changes in the burst signal, for example during a period in which the output from the ACC circuit becomes unstable such as at switching between a state including a burst and a state not including a burst, the selector connects an output from a second multiplier that controls the amplitude of the output from the band-pass filter using an ACC output monitor signal, to the color-difference demodulation circuit.

Abstract: An NTSC system chrominance signal demodulation apparatus is provided with a clock timing change circuit for burst-locking an input signal under the state where the phase is shifted by 90 degrees for every line, and phase axis rotation circuits for performing phase axis rotation, thereby to enable conversion of the phase axis of the burst signal. Therefore, demodulation of a PAL system chrominance signal can be carried out as well as demodulation of an NTSC system chrominance signal, and thereby demodulation of chrominance signals can be carried out using a common device regardless of the broadcast systems such as NTSC and PAL. Further, demodulation of chrominance signals can be carried out even under adverse conditions such as weak electric field or level compression of the burst signal.

Abstract: A color demodulation circuit that can complement an unstable state of an output from an ACC circuit and can obtain stable color-difference outputs, regardless of a burst signal in a chrominance carrier signal. Normally, a selector connects an output from a first multiplier that controls an amplitude of an output from a band-pass filter using an output from the ACC circuit, to a color-difference output demodulation circuit. However, during a period in which there are abrupt changes in the burst signal, for example during a period in which the output from the ACC circuit becomes unstable such as at switching between a state including a burst and a state not including a burst, the selector connects an output from a second multiplier that controls the amplitude of the output from the band-pass filter using an ACC output monitor signal, to the color-difference demodulation circuit.

Abstract: The center of gravity of a retaining pin which is struck into a retaining-pin receiving hole to join a rotor barrel with a rotor shaft is eccentrically positioned toward the leading end of the pin beyond the axis of the shaft so that upon rotation of the rotor, the pin is forced to thrust toward the bottom of the hole by the centrifugal force, thereby preventing the pin from pulling out of the hole.

Abstract: In a turbocharger of the type in which a turbine and a compressor are disposed in back-to-back relationship and bearings are disposed on the suction side of the compressor, the turbine and the compressor are isolated thermally from each other; the service life of the antifriction bearings is increased; lubrication oil sealability is improved; and machining of a shaft is facilitated.

Abstract: An oil film damper whose one portion is supported, whose free end portion or portions define oil film formation portions and which has a Rahmen or rigid frame structure is used so that a minimum quantity of lubricating oil only sufficient to fill clearances in which oil films are formed can have a function of satisfactorily damping shaft vibrations. A jet of lubricating oil fed from the exterior of the oil film damper is directly supplied to each ball bearing so that the satisfactory lubrication of ball bearings is ensured, the overall function of the bearing device is improved and a service life thererof is increased.

Abstract: A bearing device for a turbocharger wherein a bearing casing is interposed between a turbine casing and a compressor casing; disposed within a bearing housing of the bearing casing are a ball bearing on the side of the turbine and a ball bearing on the side of the compressor both of which is supported by a one-piece oil film damper which is floating; and a pin is loosely fitted into the oil film damper and the bearing housing so as to prevent the rotation of the oil film damper.