Abstract: A collagenase gene derived from bacteria of the species Vibrio alginolyticus is disclosed. A recombinant vector containing the gene, a host cell transformed with a plasmid containing the gene and a process for the production of a collagenase by using the host cells are also disclosed.

Abstract: Provided herein is a derivative of 2-deoxy-2-amino-4-O-phophono-D-glucopyranose, which is derived from lipid A, of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are a member in a pair selected from the group consisting of those indicated in a following table:______________________________________ Com- pound No. R.sub.1 R.sub.2 ______________________________________ I(R,R) --O--CO--(CH.sub.2).sub.12 --CH.sub.3 --O--CO--(CH.sub.2).sub.12 --CH.sub.3 II --O--CO--(CH.sub.2).sub.12 --CH.sub.3 --OH II(R,R) --O--CO--(CH.sub.2).sub.12 --CH.sub.3 --OH II(S,S) --O--CO--(CH.sub.2).sub.12 --CH.sub.3 --OH III --OH --O--CO--(CH.sub.2).sub.12 --CH.sub.3 III(R,R) --OH --O--CO--(CH.sub.2).sub.12 --CH.sub.3 III(S,S) --OH --O--CO--(CH.sub.2).sub.12 --CH.sub.3 IV(R) --H --O--CO--(CH.sub.2).sub.12 --CH.sub.3 ______________________________________The compounds of this invention include those of rectus and sinister configurations and act as mitogens for polyclonal B cells.

Abstract: Provided herein are two kinds of toxoid of elastase of Pseudomonas aeruginosa origin, one of which is obtained by treating a purified elastase produced from Pseudomonas aeruginosa with a synthetic peptide for chloroacetyl-N-hydroxy-L-leucyl-L-alanylglycinamide and the other of which is obtained by treating at first with formalin, then, with the synthetic peptide. The present invention also contemplates a method for preparing the toxoids and the use of such toxoids for preventing and treating infections caused by Pseudomonas aeruginosa on human beings and mammalian animals. Acute toxicity of the toxoids is inspected.

Abstract: A process for preparing a B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on the basic-amino-acid carbonyl in peptide bondings.

Abstract: A process for preparing B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on a lysine carbonyl in peptide bondings and produced by Achromobacter lyticus M 497-1.

Abstract: A process for preparing a B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on the basic-amino-acid carbonyl in peptide bondings.

Abstract: A process for preparing a B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on the basic-amino-acid carbonyl in peptide bondings.

Abstract: A process for preparing a B30-threonine-insulin which comprising reacting a des-B30-insulin with an excess amount of threonine derivative in the presence of an enzyme specifically acting on a lysine carbonyl in peptide bondings and produced by Achromobacter lyticus M 497-1.

Abstract: Toxoids derived from protease and elastase of Pseudomonas aeruginosa which are effective to prevent infections caused by Pseudomonas aeruginosa and production thereof.

Abstract: A three component-mixed vaccine against infections caused by Pseudomonas aeruginosa which comprises as the antigens an infection-protective common antigen OEP (Original Endotoxin Protein) obtained from P. aeruginosa, an elastase toxoid obtained from P. aeruginosa and a protease toxoid obtained from P. aeruginosa.