Abstract: [Problem] A compound useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer is provided. [Solution] The present inventors have studied about a compound that is useful as an active ingredient of a pharmaceutical composition for treating pancreatic cancer and have found that a 4-aminoquinazoline compound has an excellent G12D mutant KRAS inhibition activity and can be used as a therapeutic agent for pancreatic cancer, thus completing the present invention. The 4-aminoquinazoline compound of the present invention or a salt thereof can be used as a therapeutic agent for pancreatic cancer.

Abstract: An electric power steering device includes a worm shaft; a bearing rotatably supporting the worm shaft; a coil spring configured to bias the worm shaft toward the worm wheel via the bearing; a gear case including an insertion hole, the coil spring being insertable into the insertion hole; and plug configured to close the insertion hole. The plug includes a body part and a supporting part configured to support the coil spring. An outer peripheral surface of the plug is formed into a curved surface from the body part to the supporting part.

Abstract: A power steering device includes a worm shaft configured to rotate as an electric motor is driven; a worm wheel meshed with the worm shaft, the worm wheel being configured to transmit a rotational force of the electric motor to a rack shaft configured to turn wheels; a bearing that rotatably supports a tip side of the worm shaft; a gear case that houses the worm shaft; a biasing member configured to bias the worm shaft toward the worm wheel via the bearing; and a holder including a housing hole configured to house the bearing movably in a biasing direction of the biasing member. The holder includes a plurality of bulging parts formed to bulge radially outwardly, the bulging parts being configured to come into contact with an inner peripheral surface of the gear case.

Abstract: A power steering device includes a worm shaft configured to rotate as an electric motor is driven; a worm wheel meshed with the worm shaft, the worm wheel being configured to transmit a rotational force of the electric motor to a rack shaft configured to turn wheels; a bearing that rotatably supports a tip side of the worm shaft; a gear case that houses the worm shaft; a biasing member configured to bias the worm shaft toward the worm wheel via the bearing; and a holder including a housing hole configured to house the bearing movably in a biasing direction of the biasing member. The holder includes a plurality of bulging parts formed to bulge radially outwardly, the bulging parts being configured to come into contact with an inner peripheral surface of the gear case.

Abstract: A method of controlling objects in an information processing system includes the steps of representing objects by a tree having a hierarchical structure, providing each of the objects with a first operation-target flag which indicates whether a corresponding object is a target of a given operation, and performing the given operation on an object upon receiving of an object handling request for the given operation only if the first operation-target flag of the object indicates that the object is a target of the given operation.