Abstract: The present invention provides a small molecule compound for treating ischemic stroke, which is 4-(phenyl (phosphinoyl) methyl) piperazine-2-carboxylic acid. This small molecule compound can completely block the activation of ASICs by glutamate, and partially block the activation of NMDARs by glutamate, achieving the purpose of not affecting the physiological function of NMDARs, thereby reducing the side effects of mental symptoms and even mortality in stroke patients, and providing an effective strategy for treating ischemic stroke. In addition, the synthesis method of this small molecule compound is simple, which can reduce the cost of the pharmaceutical and has good application prospects.

Abstract: The invention provides a method for treating cerebral apoplexy and hyperbilirubinemia by the compound or reagent for competitively inhibiting or blocking combination of bilirubin and the TRPM2 channel. The compound or the reagent is competitively combined with the D1069 residue of TRPM2 channel (the analogous D1066 residue of the mouse TRPM2). It is verified that bilirubin can serve as an extracellular endogenous agonist to be directly combined with the TRPM2 channel to aggravate brain tissue damage caused by stroke and hyperbilirubinemia, K928 and/or D1069 residues are key amino acid residues for playing roles. When the K928 and/or D1069 residues are mutated or competitively combined, the bilirubin is prevented from activating the TRPM2 channel; wherein D1069 residue mutation can effectively antagonize the nerve injury effect caused by bilirubin, which would be a therapeutic target for relieving and treating ischemic stroke and hyperbilirubinemia related brain damage.

Abstract: Provided is a synthesis process for the one-step production of a monomeric polyether for polycarboxylic acid water reducing agents, wherein the monomeric polyether is synthesized in one step by mixing an initator and a catalyst at a temperature and a pressure, and then introducing same into a reaction kettle together with an epoxide at a certain ratio for ring opening polymerization. The synthesis process of the present invention realizes continuous production without the need of first synthesizing a prepolymer and then synthesizing a macromolecular monomeric polyether step by step, thereby improving the production efficiency. By separating four links, i.e.

Abstract: A preparation method of a powdery polycarboxylate superplasticizer is provided, including: mixing a superplasticizer monomer with water to produce a mixture, heating and melting the mixture to produce a melt system; carrying out a bulk polymerization reaction by adding an initiator, a chain transfer agent and an unsaturated carboxylic acid into the melt system, forming a polycarboxylate superplasticizer precursor; and neutralizing and pulverizing the polycarboxylate superplasticizer precursor to produce a powdery polycarboxylate superplasticizer. Water is added in the bulk polymerization and reacts with the superplasticizer monomer and the unsaturated carboxylic acid. While the bulk polymerization reaction is guaranteed to be efficiently carried out and the solid polycarboxylate superplasticizer is formed, the viscosity of a bulk polymerization reaction system is reduced. The superplasticizer is suitable for dry-mixed mortar, high-efficiency concrete and other products.

Abstract: Provided is a synthesis process for the one-step production of a monomeric polyether for polycarboxylic acid water reducing agents, wherein the monomeric polyether is synthesized in one step by mixing an initator and a catalyst at a temperature and a pressure, and then introducing same into a reaction kettle together with an epoxide at a certain ratio for ring opening polymerization. The synthesis process of the present invention realizes continuous production without the need of first synthesizing a prepolymer and then synthesizing a macromolecular monomeric polyether step by step, thereby improving the production efficiency. By separating four links, i.e.

Abstract: A preparation method of a powdery polycarboxylate superplasticizer is provided, including: mixing a superplasticizer monomer with water to produce a mixture, heating and melting the mixture to produce a melt system; carrying out a bulk polymerization reaction by adding an initiator, a chain transfer agent and an unsaturated carboxylic acid into the melt system, forming a polycarboxylate superplasticizer precursor; and neutralizing and pulverizing the polycarboxylate superplasticizer precursor to produce a powdery polycarboxylate superplasticizer. Water is added in the bulk polymerization and reacts with the superplasticizer monomer and the unsaturated carboxylic acid. While the bulk polymerization reaction is guaranteed to be efficiently carried out and the solid polycarboxylate superplasticizer is formed, the viscosity of a bulk polymerization reaction system is reduced. The superplasticizer is suitable for dry-mixed mortar, high-efficiency concrete and other products.