Abstract: A pyridine derivative and use thereof are provided. The compound has an obvious inhibitory effect on the activity of KRAS and PI3K proteins, can be used as a KRAS and/or PI3K protein inhibitor, and can be used for preparing a drug for treatment of diseases such as KRAS or PI3K protein-mediated cancer. The compound has an extremely strong inhibitory effect on a KRAS G12C inhibitor (e.g. AMG-510) drug-resistant cancer cells, and has a wide application prospect thereof.

Abstract: A light-emitting diode includes an epitaxial layer, including a first semiconductor layer, a light-emitting layer configured to emit light, and a second semiconductor layer sequentially stacked in that order, and has a first surface and a second surface opposite to each other; a first insulating reflective layer, disposed on the first surface of the epitaxial layer; and a second insulating reflective layer, disposed on the second surface of the epitaxial layer. Reflectivity of the first insulating reflective layer to light with a first incident angle is lower than reflectivity of the second insulating reflective layer to light with a third incident angle, the first incident angle is in a range of 0° to 10°, and the third incident angle is in a range of 0° to 10°. Therefore, a lateral light emission angle and an extreme light emission angle of the light-emitting diode can be improved, which meet market demand.

Abstract: A reusable ultrasonic scalpel comprising a handle assembly and an ultrasonic waveguide extended to the distal end transmitting ultrasonic mechanical energy. Outside the ultrasonic waveguide is a sheath assembly, and the sheath assembly is detachably connected to the handle assembly by a quick connecting mechanism. The beneficial effects are mainly reflected on: reliable installation, easy to disassemble, easy to clean and disinfect. The sheath assembly serving as a consumable may be quickly replaced, while the remaining parts may be reused, and may undergo cleaning and high temperature steam sterilization. Thus, the cost of surgical consumables is greatly reduced, the burden on patients is reduced, and the risk of cross-infection when using the ultrasonic scalpel bar is also reduced.

Abstract: A display substrate and a manufacturing method therefor, and a display apparatus are provided. The display substrate includes a plurality of circuit units, a scan signal line for providing a scan signal for the circuit units, and a first power supply line (51) for providing a power supply signal; wherein at least one circuit unit includes a pixel drive circuit, the pixel drive circuit includes a first shield electrode (34), which is connected to the first power supply line (51), an orthographic projection of the first shield electrode (34) on a plane of the display substrate at least partially overlaps an orthographic projection of the scan signal line on the plane of display substrate.

Abstract: The present application pertains to the technical field of vehicles, and in particular to a vehicle intelligent control system based on a dual independent control system and a corresponding vehicle. The system includes a locomotive terminal and a cloud server. The locomotive terminal includes a first control system and a second control system both being operable independently and capable of exchanging data with each other in real time. The first control system monitors an operation state of the vehicle in real time and transmits at least part of operation state data to the second control system in real time, and controls an operation of the vehicle according to an internal preset instruction and a control instruction received from the second control system.

Abstract: The present disclosure provides a hetero-integrated terahertz low-noise miniaturized image frequency rejection transceiver front-end, including an intermediate frequency circuit and a terahertz circuit arranged up and down, where the terahertz circuit includes a local oscillator frequency tripler, a 135° 3 dB filter coupler, a radio frequency waveguide power divider, and two quartz hetero-integrated subharmonic mixers; resonant cavities of an input unit, a first output unit, an isolation unit, and a second output unit of the 135° 3 dB filter coupler are sequentially coupled through resonant grooves to form a ring structure, a cavity length of the resonant cavity of the input unit is twice that of the resonant cavities of the other three units, and an electrical length of a waveguide of the first output unit is 45° different from that of a waveguide of the second output unit.

Abstract: A media control method is applied to a first fusion media application system. The media control method includes: determining target content from a target media source, and obtaining a content identifier of the target content and a media source identifier of the target media source; obtaining a target interface corresponding to the media source identifier, and obtaining a target media server of the target media source; and obtaining the target content from the target media server based on the content identifier through the target interface.

Abstract: The present disclosure relates to novel pan-KRAS glutarimide-containing compounds with KRAS degradation activities, pharmaceutical compositions containing such compounds, and their use in prevention and treatment diseases and conditions.

Abstract: Embodiments of this application provide an information transmission method and an apparatus. The transmit end sends a first coded bit sequence based on a to-be-transmitted coded bit sequence. The receive end receives and decodes a first to-be-decoded sequence, and sends first indication information if the decoding fails, where the first indication information includes information about a location, in the to-be-transmitted coded bit sequence, of at least one sent coded bit in the to-be-transmitted coded bit sequence. The transmit end receives the first indication information, and sends a second coded bit sequence based on the first indication information, where the second coded bit sequence includes the at least one sent coded bit in the to-be-transmitted coded bit sequence and/or at least one unsent coded bit in the to-be-transmitted coded bit sequence.

Abstract: The present disclosure relates to novel CDK inhibitors, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of diseases and conditions associated with CDK.

Abstract: Provided is a display panel. The display panel includes: a base substrate, including a display region and a periphery region at least partially surrounding the display region, wherein the display region includes a first display region and a second display region disposed at least on one side of the first display region, a light transmittance of the first display region being greater than a light transmittance of the second display region; a plurality of first pixel units disposed on the base substrate and in the first display region; and a plurality of signal lines disposed at least in the first display region and electrically connected to the plurality of first pixel units, wherein the plurality of signal lines include a plurality of first signal lines and a plurality of second signal lines.

Abstract: The display substrate includes pixel regions (PD) and blank regions (PB), the pixel region (PD) includes first power supply lines (70) and a second power supply line (80), the first power supply lines (70) are configured to continuously provide high-level signals to a pixel driving circuit, and the second power supply line (80) is configured to continuously provide low-level signals to a patterned cathode (403), each blank region (PB) includes high-voltage power supply connecting lines connected to the first power supply lines (70) in the adjacent pixel regions (PD) and low-voltage power supply connecting lines connected to the second power supply lines (80) in the adjacent pixel regions (PD), the first power supply lines (70) and the high-voltage power supply connecting lines form a high-voltage power supply wiring with a mesh connection structure.

Abstract: A display substrate is provided to include: a base substrate including a display area and a peripheral area surrounding the display area; pixel units in array are in the display area; a driving module is in the peripheral area and is configured to provide electrical signals for the pixel units, to control the pixel units to operate; the driving module includes driving circuits each provided with a corresponding operating signal line group in the peripheral area; the signal line group includes at least two operating signal lines connected to the corresponding driving circuit, to provide electrical signals thereto; the at least two operating signal lines include first and second clock signal lines; the first clock signal lines for at least two driving circuits are a same first clock signal line; and/or the second clock signal lines for the at least two driving circuits are a same second clock signal line.

Abstract: Disclosed are a data access method and apparatus, a device, and a computer-readable storage medium, the method including: creating a cache pool matching memory capacity of an accelerator card on a host side, the cache pool containing cache blocks divided according to a set capacity unit; under a condition that acquiring a read instruction of target data, calling from the cache pool a target cache block matching capacity of the target data; storing the target data into the target cache block, recording meta information about the target cache block, and setting write protection for the target cache block; and executing a data access operation according to state information corresponding to the cache blocks, and adjusting the state information about the cache blocks after executing the data access operation.

Abstract: Disclosed are a data access method and apparatus, a device, and a computer-readable storage medium, the method including: creating a cache pool matching memory capacity of an accelerator card on a host side, the cache pool containing cache blocks divided according to a set capacity unit; under a condition that acquiring a read instruction of target data, calling from the cache pool a target cache block matching capacity of the target data; storing the target data into the target cache block, recording meta information about the target cache block, and setting write protection for the target cache block; and executing a data access operation according to state information corresponding to the cache blocks, and adjusting the state information about the cache blocks after executing the data access operation.

Abstract: The present invention provides novel IL-12 Fc fusion proteins, methods of making and using the same. The IL-12 Fc fusion proteins are useful for treatment of cancer and can be used in combination with checkpoint blockade.

Abstract: A light-emitting device includes a substrate, a first and second mesa structures disposed on the substrate, at least one current blocking element, at least one conductive bridging element, and first and second conductive pads. The conductive bridging element is disposed on the current blocking element, and is electrically connected to the first and second mesa structures. The first and second conductive pads are electrically connected to the first and second mesa structures, respectively. The conductive bridging element has a projection image that is spaced apart from those of the first and second conductive pads in a plan view of the light-emitting device. A light-emitting module including the light-emitting device, and a display apparatus including the light-emitting device are also disclosed.

Abstract: A display substrate, a display panel and a display apparatus are provided. The display substrate includes a first display region and a second display region, and a light transmittance of the first display region is greater than a light transmittance of the second display region. A plurality of sub-pixels located in the first display region includes a plurality of sub-pixel groups, each sub-pixel group includes a first sub-pixel and a second sub-pixel, the first pixel driving circuit includes a first sub-pixel driving circuit and a second sub-pixel driving circuit. The first sub-pixel driving circuit includes at least a first reset transistor, the second sub-pixel driving circuit includes at least a second reset transistor, and the first reset transistor of the first sub-pixel driving circuit and the second reset transistor of the second sub-pixel driving circuit are at least partially shared with each other.

Abstract: A display substrate and a manufacturing method therefor, and a display apparatus. The display substrate includes a base substrate, a second power line, a data signal line and a plurality of sub-pixels, wherein at least one sub-pixel includes a pixel driving circuit and a light emitting device connected to the pixel driving circuit; a semiconductor layer and a plurality of conducting layers, which are disposed at one side of the semiconductor layer away from the base substrate, are disposed on the base substrate, a first electrode is arranged in at least one conducting layer, the first electrode is connected to the second power line, and there is an overlapping area between an orthographic projection of the first electrode on the base substrate and an orthographic projection of the data signal line on the base substrate.

Abstract: The device (100) comprises a cavity (101) and at least two microporous membranes (102), wherein the microporous membranes (102) are arranged in series in the cavity (101) and divide the cavity (101) into a plurality of chambers (1011); each of the microporous membranes (102) is provided with micropores (103), and two adjacent chambers (1011) are in communication via the micropores (103); and each of the chambers (1011) is provided with an electrode (1012).