Abstract: The present disclosure provides a class of Pyridopyrimidine compounds having a structure shown in Formula (I) or their pharmaceutically acceptable salts, or stereoisomers or prodrug molecules and applications thereof. The compounds in the present disclosure can efficiently and selectively degrade AKT3 protein in cells without affecting AKT1/2, thereby significantly inhibiting tumor cell proliferation mediated by high expression of AKT3 protein. It can be used to prepare therapeutic drugs for cancer and other diseases related to abnormal expression of AKT3 protein.

Abstract: A bioreactor includes a base and a lid. The base includes two opposing curved or convoluted surfaces, two opposing flat surfaces, a window disposed on one of the flat surfaces, the window having a higher degree of transparency compared to other portions of the base, wherein images or videos of cells are captured through the window by non-invasive ISM device, and a rounded bottom. The lid is attachable to the base. The lid includes a shaft and a semipermeable membrane attached to the shaft, the semipermeable membrane being permeable to oxygen but impermeable to viruses and bacteria. The PAT-based online analysis directs the adaptive manipulations of bioreactor towards efficient, automated, and GMP-compliant clinical protocols of cell culture.

Abstract: Disclosed are a new AXL-targeting monoclonal antibody and antibody-drug conjugate. Also disclosed is a method for preparing said antibody and antibody-drug conjugate. The AXL antibody of the present invention can bind with purified human AXL protein and multiple AXL on tumor cell surface with high effectiveness and high specificity. Said humanized antibody also has high affinity and low immunogenicity. Said AXL antibody-drug conjugate has markable performance against tumors having high AXL expression.

Abstract: The present disclosure relates to the technical field of fiber-optic gas sensing and laser photoacoustic spectroscopy, and reliability of a gas detection system is improved by actively selecting a working frequency of low noise interference combined with an optical fiber photoacoustic sensing probe capable of isolating high-frequency noise. A gas enters a photoacoustic microcavity through gaps on a sound-sensitive diaphragm after diffusing into a miniature air chamber through a plurality of micropores. Photoacoustic excitation light is incident into the photoacoustic microcavity through a fiber-optic collimator and then excited to generate a photoacoustic pressure wave to cause the sound-sensitive diaphragm to vibrate periodically. An end face of a single-mode optical fiber and the sound-sensitive diaphragm constitutes a fiber-optic Fabry-Perot interferometer. The interferometer measures a deflection of the diaphragm and inverts a concentration of the to-be-measured gas.

Abstract: Systems and methods are provided for performing random walk graph computing. One method may comprise generating a subset of walkers on a graph, maintaining the generated subset of walkers in a walker pool in a memory, loading a coarse-grained block of the graph from a non-volatile storage into a block buffer of the memory, generating pre-sampled edges for vertices in the coarse-grained block, storing the pre-sampled edges into a pre-sampled edge buffer allocated for the coarse-grained block and moving one or more walkers of the generated subset of walkers using the pre-sampled edges stored in the pre-sampled edge buffer. The generated subset of walkers may have an initial number determined based on a memory space allocated to the walker pool.

Abstract: An outer loop initial value adjustment method, a device, and a readable storage medium are disclosed. The method may include: acquiring feature information of a plurality of User Equipment (UEs) scheduled by a cell; performing raster division on the feature information of the plurality of UEs to obtain a plurality of rasters; determining an outer loop corresponding to each of the rasters, where an outer loop value of each raster is within a target Block Error Rate (BLER) range; determining a target raster corresponding to a target UE according to the feature information of the target UE, where the target UE is one of the plurality of UEs scheduled by the cell; and determining the outer loop value corresponding to the target raster as an initial outer loop value of the target UE.

Abstract: An information processing apparatus includes: a controller that outputs notification information based on input information; and a processor that executes system processing based on an operating system (OS) and operation of thermal control processing by control of a Basic Input Output System (BIOS) using the notification information output from the controller. The controller accepts an operation signal indicative of an operated key according to a user's operation on a keyboard; determines whether the operated key is of a specific combination of keys based on the accepted operation signal; upon making a determination that the operated key is of the specific combination of keys, outputs, to the processor, a result of the determination as the notification information; and without another key being pressed after the result of the determination is output from the controller, the processor executes the thermal control processing based on the result of the determination.

Abstract: A testing circuit for multiple SMs of a cascaded converter and a control method thereof are provided. A current generator generates a testing current flowing into a testing module group. The testing module group includes two series-connected testing arms that each contains multiple SMs, or in an alternative way, the testing module group is composed of one or multiple testing units connected in series, and each testing unit includes two testing SMs connected in series reversely. The testing circuit the control method thereof realizes a mission profile emulation of the multiple SMs of the cascaded converter in both inverting and rectifying modes simultaneously to improve a test efficiency. A reverse series connection structure of the two testing SMs offsets a DC component in a capacitor voltage to reduce a power supply voltage required for a test. Dynamic and static control methods under different modulations for the test circuit are provided.

Abstract: An information processing apparatus includes: a controller that outputs notification information based on input information; and a processor that functions as a system processing unit that executes system processing based on an operating system (OS) and a Basic Input Output System (BIOS) processing unit that executes control related to the performance of the system processing by control of a BIOS using the notification information output from the controller.

Abstract: A bioreactor includes a culture medium vessel housing culture medium. The culture medium vessel further includes a first side surface including a first transparent optical window; and a second side surface parallel to the first surface and including one or more sensor adapters to fix optical sensors. A cell retention vessel is disposed underneath and connected to the culture medium vessel, the cell retention vessel housing biological cells and having: a top surface that intersects a base of the culture medium vessel, and a second transparent optical window indented into the top surface at a first corner of the top surface. A semipermeable membrane is disposed at a bottom of the cell retention vessel, and a frame comprising a grid is disposed underneath the semipermeable membrane.

Abstract: The present disclosure relates to the technical field of semiconductors, and provides a method of manufacturing a semiconductor structure and a semiconductor structure. The method of manufacturing a semiconductor structure includes: providing an initial structure, wherein the initial structure includes a dielectric layer and an initial metal interconnect structure, the initial metal interconnect structure penetrates the dielectric layer and covers a top surface of the dielectric layer; treating an exposed surface of the initial metal interconnect structure by using a first gas; cleaning the exposed surface of the initial metal interconnect structure by using a first liquid; and grinding to remove a partial structure of the initial metal interconnect structure, wherein a retained part of the initial metal interconnect structure forms a metal interconnect structure.

Abstract: A bioreactor includes a culture medium vessel housing culture medium. The culture medium vessel further includes a first side surface including a first transparent optical window; and a second side surface parallel to the first surface and including one or more sensor adapters to fix optical sensors. A cell retention vessel is disposed underneath and connected to the culture medium vessel, the cell retention vessel housing biological cells and having: a top surface that intersects a base of the culture medium vessel, and a second transparent optical window indented into the top surface at a first corner of the top surface. A semipermeable membrane is disposed at a bottom of the cell retention vessel, and a frame comprising a grid is disposed underneath the semipermeable membrane.

Abstract: An electronic device, a wireless communication method, and a computer-readable storage medium. The electronic device comprises a processing circuit, configured to send two reference signals using identical time-frequency resources and respectively using two beams in a beam pair, wherein a spatial distance between the two beams in the beam pair is greater than a predetermined value, and the two reference signals satisfy a predetermined constraint relation. The efficiency of a beam training process can be improved, and the time consumption of the beam training process is reduced, thereby achieving a compromise between beam training overheads and beamforming gains.

Abstract: The embodiments of the present disclosure provide systems and methods for outbound forecasting, comprising receiving an initial distribution of priority values to each fulfillment center (FC) in each region, running a simulation, using a simulation algorithm, of the initial distribution, calculating an outbound capacity utilization value of each FC, determining a number of FCs comprising an outbound capacity utilization value that exceeds a predetermined threshold, feeding the simulation algorithm with the determined number of FCs to generate one or more additional distributions of priority values, generating a FC priority filter comprising an optimal set of priority values based on the one or more additional distributions of priority values, and modifying an allocation of a plurality of SKUs among a plurality of FCs based on the generated FC priority filter.

Abstract: A bioreactor includes a culture medium vessel housing culture medium. The culture medium vessel further includes a first side surface including a first transparent optical window; and a second side surface parallel to the first surface and including one or more sensor adapters to fix optical sensors. A cell retention vessel is disposed underneath and connected to the culture medium vessel, the cell retention vessel housing biological cells and having: a top surface that intersects a base of the culture medium vessel, and a second transparent optical window indented into the top surface at a first corner of the top surface. A semipermeable membrane is disposed at a bottom of the cell retention vessel, and a frame comprising a grid is disposed underneath the semipermeable membrane.

Abstract: A bioreactor includes a base and a lid. The base includes two opposing curved or convoluted surfaces, two opposing flat surfaces, a window disposed on one of the flat surfaces, the window having a higher degree of transparency compared to other portions of the base, wherein images or videos of cells are captured through the window by non-invasive ISM device, and a rounded bottom. The lid is attachable to the base. The lid includes a shaft and a semipermeable membrane attached to the shaft, the semipermeable membrane being permeable to oxygen but impermeable to viruses and bacteria. The PAT-based online analysis directs the adaptive manipulations of bioreactor towards efficient, automated, and GMP-compliant clinical protocols of cell culture.

Abstract: The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods useful for detecting and treating esophageal cancer. In a specific embodiment, a method for identifying a subject having esophageal adenocarcinoma (EAC) comprises (a) extracting genomic DNA from a sample obtained from the subject; (b) performing a conversion reaction on the genomic DNA in vitro to convert unmethylated cytosine to uracil by deamination; and (c) detecting nucleic acid methylation of one or more genes in the converted genomic DNA, wherein detecting nucleic acid methylation identifies the subject as having EAC. The one or more genes can comprise ABCB1, BMP3, COL23A1, FBN1, FADS1 and PRDM2. In a more specific embodiment, the one or more genes comprise at least three of ABCB1, BMP3, COL23A1, FBN1, FADS1 and PRDM2.

Abstract: Disclosed is a method of providing information related to an order by an electronic apparatus, the method including acquiring necessary order information including information on at least one order item, information on an order quantity of the at least one order item, and information on a lead time of the at least one order item, confirming a reference date based on the information on the lead time, confirming information on a remaining storage capacity of a fulfillment center on the reference date, confirming a target order item whose order quantity is to be adjusted from the necessary order information when order quantity corresponding to the necessary order information exceeds the remaining storage capacity of the fulfillment center on the reference date, and providing updated order information in which the order quantity of the target order item is adjusted.