Abstract: A method, computer system, and a computer program product for improving debugging speed by rearranging debugging priority functions. In one embodiment, runtime input may be received about a program to be debugged. Feedback information is obtained about at least one similar program previously debugged. The compiling time information and runtime information are analyzed to determine a status of functions including one or more focused functions that will be used frequently and one or more unreachable functions that may never will be executed. A priority list of debugging functions is generated based on the feedback information, the runtime input and a function status. A plurality of debugging information are rearranged and parsed on the priority list prior to said program being debugged based on said debugging information.

Abstract: A computer-implemented method, system and computer program product for reducing register pressure. Loops of a computer program with a number of live variables that exceeds a threshold number, such as the number of available registers with capacity to store data, are identified. Such identified loops may be the to be subject to high register pressure. Upon identifying such loops in the computer program, chains within each identified loop are identified, where each chain includes load and store instructions from the same induction address and where the variable offsets of the load and store instructions are loop invariants. The address expressions for the load and store instructions in the identified chains may then be modified or changed to reuse common variable offsets using an analysis and transformation process. By reusing common variable offsets, there are less variable offsets that need to be stored in the registers thereby mitigating register pressure.

Abstract: A computer-implemented method, system and computer program product for reducing register pressure. Loops of a computer program with a number of live variables that exceeds a threshold number, such as the number of available registers with capacity to store data, are identified. Such identified loops may be the to be subject to high register pressure. Upon identifying such loops in the computer program, chains within each identified loop are identified, where each chain includes load and store instructions from the same induction address and where the variable offsets of the load and store instructions are loop invariants. The address expressions for the load and store instructions in the identified chains may then be modified or changed to reuse common variable offsets using an analysis and transformation process. By reusing common variable offsets, there are less variable offsets that need to be stored in the registers thereby mitigating register pressure.

Abstract: Managing source code change set commits to decrease time to identify software bugs in versions of a software project is provided. An initial order of relevant commits corresponding to the software project is determined in a priority queue based on a weight of each respective commit of the relevant commits. The initial order of the relevant commits is adjusted in the priority queue based on a build distance between the relevant commits of affected source files. A particular commit having a highest priority ranking is selected in the priority queue for build and test. The build and the test of the particular commit having the highest priority ranking in the priority queue is executed.

Abstract: A method, computer system, and a computer program product for improving debugging speed by rearranging debugging priority functions. In one embodiment, runtime input may be received about a program to be debugged. Feedback information is obtained about at least one similar program previously debugged. The compiling time information and runtime information are analyzed to determine a status of functions including one or more focused functions that will be used frequently and one or more unreachable functions that may never will be executed. A priority list of debugging functions is generated based on the feedback information, the runtime input and a function status. A plurality of debugging information are rearranged and parsed on the priority list prior to said program being debugged based on said debugging information.

Abstract: The present application relates to SARS-CoV-2 virus-like particles (VLP) and related plasmids, compositions, and methods. The VLP can comprise a modified spike glycoprotein, a matrix protein, a nucleoprotein N and an envelope protein of SARS-CoV-2, where the modified spike glycoprotein comprises an S1 domain and an S2 domain, and includes one or more modifications. These modifications can include: linking the S1 and S2 domains via generation of disulfides bonds between the S1 and S2 domains; linking intra-polypeptide and inter-polypeptide S2 helices of the S2 domain; and substitution of one or more non-cysteine residues with a cysteine residue to generate one or more disulfide bonds. The modifications can stabilize a prefusion conformation of the spike glycoprotein and prohibit a transition to a post-fusion structure.

Abstract: Provided are embodiments for a method of performing register pressure targeted function splitting. The method can include determining a candidate region of a function, the candidate region comprising variables, and determining a number of available registers in a computing system for allocating the variables of the function. The method can also include grouping the variables in the candidate region into first variables and second variables based at least in part on the number of available registers, and splitting the candidate region of the function into split functions based at least in part on the grouping of the variables. Also provided are embodiments for a computer program product and a system for performing register pressure targeted function splitting.

Abstract: Provided are embodiments for a method of performing register pressure targeted function splitting. The method can include determining a candidate region of a function, the candidate region comprising variables, and determining a number of available registers in a computing system for allocating the variables of the function. The method can also include grouping the variables in the candidate region into first variables and second variables based at least in part on the number of available registers, and splitting the candidate region of the function into split functions based at least in part on the grouping of the variables.

Abstract: Apparatuses, systems, and techniques to cause usage of information by a computer program to be reduced based, at least in part, on one or more data structures used to monitor use of the information. In at least one embodiment, usage of information by a computer program is caused to be reduced based, at least in part, on one or more data structures used to monitor use of the information based on, for example, CUDA or other parallel computing platform code.

Abstract: Apparatuses, systems, and techniques to cause usage of information by a computer program to be increased based, at least in part, on one or more data structures used to monitor use of the information. In at least one embodiment, usage of information by a computer program is caused to be increased based, at least in part, on one or more data structures used to monitor use of the information based on, for example, CUDA or other parallel computing platform code.

Abstract: Apparatuses, systems, and techniques to generate one or more data structures to be used to monitor use of information by a computer program. In at least one embodiment, one or more data structures to be used to monitor use of information by a computer program are generated, based on, for example, CUDA or other parallel computing platform code.

Abstract: The present invention includes a live, self-attenuated therapeutic vaccine, virus and methods of making and using the same, comprising: an isolated virus comprising a viral genome that expresses one or more viral antigens; and an artificial microRNA 30 (amiR-30) expression cassette inserted into a viral neuraminidase (NA) or a viral non-structural (NS) gene segment that expresses an amiR-30 that specifically inhibits the expression of a host gene essential for influenza virus replication in host cells.

Abstract: Provided herein is a mammalian expression system for producing recombinant porcine circovirus type 2 (PCV2) virus-like particles (VLPs). The expression system includes a mammalian cell and a plasmid that comprises a PCV2 gene encoding a capsid protein. The PCV2 gene is codon optimized, and the mammalian cell is transfected with the plasmid. The expression system produces recombinant PCV2 VLPs, such as PCV2d VLPs. Also provided herein are a method for producing porcine circovirus type 2 (PCV2) virus-like particles (VLPs), as well as a PCV2 VLP generated by the method.

Abstract: Embodiments of the present disclosure relate to runtime type identification (RTTI) of an object. In an embodiment, a computer-implemented method is disclosed. A class inheritance relationship between a plurality of classes in at least one source code section is generated. Respective type identifications are assigned to identify the classes in the class inheritance relationship. In accordance with presence of a first operation related to accessing a target pointer to an object of a target class of the classes, a type identification for the target class is caused to be recorded with at least one bit of a memory address of the target pointer that can be omitted in addressing the target pointer. RTTI is caused to be performed based on the class inheritance relationship and the at least one bit of the memory address of the target pointer. In other embodiments, a system and a computer program product are disclosed.

Abstract: Embodiments of the present disclosure relate to runtime type identification (RTTI) of an object. In an embodiment, a computer-implemented method is disclosed. A class inheritance relationship between a plurality of classes in at least one source code section is generated. Respective type identifications are assigned to identify the classes in the class inheritance relationship. In accordance with presence of a first operation related to accessing a target pointer to an object of a target class of the classes, a type identification for the target class is caused to be recorded with at least one bit of a memory address of the target pointer that can be omitted in addressing the target pointer. RTTI is caused to be performed based on the class inheritance relationship and the at least one bit of the memory address of the target pointer. In other embodiments, a system and a computer program product are disclosed.

Abstract: Embodiments of the present disclosure relate to methods, systems, and computer program products for monitoring a state of an application. A target object that is to be monitored in an application may be determined in response to receiving a monitoring configuration. A position of the target object in source codes of the application may be identified. A state of the target object may be monitored in response to the application being traced to a location corresponding to the position.

Abstract: The present invention includes a live, self-attenuated therapeutic vaccine, virus and methods of making and using the same, comprising: an isolated virus comprising a viral genome that expresses one or more viral antigens; and an artificial microRNA 30 (amiR-30) expression cassette inserted into a viral neuraminidase (NA) or a viral non-structural (NS) gene segment that expresses an amiR-30 that specifically inhibits the expression of a host gene essential for influenza virus replication in host cells.