Abstract: An application of a novel thiazole derivative in the treatment of an RNA virus infection and the preparation of a drug for treating an RNA virus infection. Specifically, the present invention relates to a use of a compound represented by the following formula I and a pharmaceutical composition containing a compound represented by the following formula I in treating an RNA virus infection and preparing a drug for treating a coronavirus infection.

Abstract: The present invention relates to methods of treating pancreatic cancer with particular dosage regimes of antibodies that bind colony stimulating factor 1 receptor (CSF1R) (e.g. cabiralizumab) in combination with antibodies that bind programmed cell death 1 (PD-1) (e.g. nivolumab).

Abstract: A method of pushing a message notification to a message recipient comprises capturing a message that is sent to a message recipient. The method further comprises extracting a first set of one or more message keywords from the message. The method further comprises extracting a second set of one or more recipient keywords from one or more digital resources associated with the message recipient. The method further comprises evaluating a correspondence between the first set and the second set. The method further comprises pushing, to the message recipient, at a notification time, a notification of the message. The notification time depends on the evaluated correspondence.

Abstract: A system and method for switching from a locally executing application to a remotely executing application. A method includes: detecting a launch of an application on a computing device, the application being executable locally on the computing device; rendering an element in a user interface presented within a display of the computing device, the element configured to substitute the application with a corresponding application that executes on a remote computing device; and in response to input received on the element, launching the corresponding application on the remote computing device and terminating execution of the application on the computing device.

Abstract: The present invention relates to methods of preparing a therapeutic exosome using a protein newly-identified to be enriched on the surface of exosomes. Specifically, the present invention provides methods of using the proteins for affinity purification of exosomes. It also provides methods of localizing a therapeutic peptide on exosomes, and targeting exosomes to a specific organ, tissue or cell by using the proteins. The methods involve generation of surface-engineered exosomes that include one or more of the exosome proteins at higher density, or a variant or a fragment of the exosome protein.

Abstract: In various examples, live perception from sensors of a vehicle may be leveraged to generate object tracking paths for the vehicle to facilitate navigational controls in real-time or near real-time. For example, a deep neural network (DNN) may be trained to compute various outputs—such as feature descriptor maps including feature descriptor vectors corresponding to objects included in a sensor(s) field of view. The outputs may be decoded and/or otherwise post-processed to reconstruct object tracking and to determine proposed or potential paths for navigating the vehicle.

Abstract: An electromagnetic field simulation method based on subgridding technique and one-step alternating-direction-implicit-finite-difference time-domain (ADI-FDTD) algorithm is provided herein. The method includes establishing an electromagnetic field simulation model by setting an absorption boundary condition, a periodic boundary condition, a total field boundary condition and a scattering field boundary condition based on the one-step ADI-FDTD algorithm, subgridding technique and FDTD algorithm. The electromagnetic field simulation model is configured to select a detection point and a detection surface, obtain a time-domain waveform diagram of a reflection field of a simulation area, a time-domain waveform diagram of a transmission field of the simulation area and frequency-domain information of the simulation area, and simulate an electromagnetic field, by the electromagnetic field simulation model.

Abstract: The present disclosure relates to modified extracellular vesicles, e.g., exosomes, comprising a targeting moiety, wherein the targeting moiety can specifically bind to markers expressed on distinct immune cells (e.g., dendritic cells). Also provided herein are methods for using the exosomes to treat and/or prevent a range of medical disorders.

Abstract: Disclosed are a method and apparatus for training an image restoration model, an electronic device, and a computer-readable storage medium. The method for training an image restoration model includes: pre-processing training images to obtain a low-illumination image sample set (110); determining, based on low-illumination image samples in the low-illumination image sample set and the image restoration model, a weight coefficient of the image restoration model (120), wherein the image restoration model is a neural network model determined on a U-Net network and a deep residual network; and adjusting the image restoration model according to the weight coefficient, and further training the adjusted image restoration model using the low-illumination image samples until the image restoration model restores parameters of all the low-illumination image samples in the low-illumination image sample set into a preset range (130).

Abstract: In one aspect, an example methodology implementing the disclosed techniques can include, by a computing device, responsive to a request for information regarding messages associated with a user and another user, a message associated with the user and the another user, the message sent or received via an application from a plurality of applications. The method can also include, by the computing device, identifying one or more other messages associated with the user and the another user based on metadata of the message, at least one of the one or more other messages sent or received via another application of the plurality of applications, the another application being different than the application. The method can further include, by the computing device, outputting information regarding the one or more other messages.

Abstract: Systems and methods are provided for a battery management system (BMS) having a protection circuit. In one example, a vehicle battery system may include the BMS, the BMS including a cutoff circuit coupled to a short-circuit protection circuit, and a battery pack, wherein the short-circuit protection circuit may include a diode array, cathodes of the diode array being coupled to a positive terminal post of the battery pack and anodes of the diode array being coupled to a negative terminal post of the battery pack. In some examples, the cutoff circuit may further be coupled to a reverse bias protection circuit including a switchable current path arranged between a control input of the cutoff circuit and an output of the cutoff circuit. In this way, the vehicle battery system may be protected from unexpected voltage conditions via the BMS redirecting and dissipating excess current away from the cutoff circuit.

Abstract: An ultrasonic stepping motor device for generating ultra-fine single droplet includes a valve housing, a valve core, and a spring. The valve core and the spring are installed inside the valve housing, and the valve core abuts against a liquid inlet of the valve housing under an elastic force of the spring. The valve housing is connected with a injector through a catheter, and the catheter is driven for linear operation by the inverse piezoelectric effect of piezoelectric ceramics through an ultrasonic linear motor. A right end of the catheter is equipped with a rubber piston, and the rubber piston is arranged in a cavity of the injector and matched with the injector. Since the piezoelectric vibrator driven catheter can produce nano feed length, and the volume of droplets overflowed each time can reach micron level, which can meet the requirements of producing micro droplets.

Abstract: A computing device configured to determine current user status information is provided. The computing device includes a computer readable memory, a network interface, and at least one processor operably coupled to the memory and the network interface. The at least one processor can be configured to receive, via the network interface from a first end-user application being of a first type, a first message specifying status information of a first user, process the status information of a first user to determine current user status information for the first user, generate a second message specifying the current user status information for the first user, and transmit the second message to a second end-user application being of a second type distinct from the type of the first end-user application such that at least one second user can review the current status information for the first user.

Abstract: A network security situation awareness method based on collaborative learning is provided.

Abstract: A computing device may include a memory and a processor coupled to the memory and configured to provide access to a computing session for a user through a user interface, and cooperate with a digital camera to detect activity other than that of the user in a field of view. Responsive to the detection, the processor may further block input of data to the user interface and permit viewing of the user interface. Responsive to an attempt to input data via the user interface, the processor may continue to block input of data and obstruct viewing of the user interface.

Abstract: A system for human interaction with virtual objects comprises: a touch sensitive surface, configured to detect a position of a contact made on the touch sensitive surface; a reference layer rigidly attached to the touch sensitive surface and comprising one or more patterns; a display device, configured to display a virtual object that is registered in a reference coordinate fixed with respect to the touch sensitive surface; one or more image sensors rigidly attached to the display device, configured to capture an image of at least a portion of the one or more patterns; and at least one processor, configured to determine a position and an orientation of the display device with respect to the touch sensitive surface based on the captured image, and identify an interaction with the virtual object based on the detected position of the contact made on the touch sensitive surface.

Abstract: A system and method for enhancing online meeting creation. A disclosed method includes: receiving a meeting title from a meeting agent, the meeting agent configured to interface with a meeting tool configured to create an online meeting for a user; analyzing the meeting title to identify a set of matching records from a meeting records database; determining a list of recommended attendees based on the set of matching records; and returning the list of recommended attendees to the meeting agent.

Abstract: Methods, apparatuses, and systems for grouping topics for users from different communication platforms are described herein. For example, a computing device may receive, from a user and via a communication platform, a request for sending content associated with the communication platform to the computing device. The computing device may determine, based on the received request, one or more keywords from the content. In addition, the computing device may determine a topic based on the one or more keywords. In addition, the computing device may determine a similarity between the determined topic and one or more stored topics. The one or more stored topics may be associated with one or more additional users. Further, based on a determination that the similarity satisfies a threshold, the computing device may send, to the user, a message identifying the one or more additional users.

Abstract: The present disclosure relates to extracellular vesicles (EVs) that are capable of targeting a cell in the CNS of a subject. Also provided herein are methods for producing the EVs and methods for using the EVs to treat and/or prevent diseases or disorders of the CNS (e.g., neurological disorders).

Abstract: A system and method for translating among time zones in text-based messages. A disclosed method includes: receiving a text-based message sent from a first device to a second device; detecting whether the text-based message includes a specified time; in response to detecting that the text-based message includes the specified time: calculating a translated time that converts the specified time from a first time zone associated with the first device to a second time zone associated with the second device; and packaging the translated time with the text-based message, wherein the translated time is viewable by a user of the second device via a visual indictor; and forwarding the text-based message with the translated time to the second device.