Abstract: A new nanobody targeting human HER2/ErbB2 (HER2-Nanobody, HER2-Nb), a method for preparing same, and use thereof are provided. The monoclonal nanobody efficiently and specifically binds to a purified HER2 protein and HER2 on the surface of a tumor cell, blocks a signal pathway of tumor HER2, and can be used for preparing a therapeutic antibody, an antibody-fusion protein or an antibody-drug conjugate targeting HER2-positive tumors.

Abstract: A novel nanobody (Nb) and a nanobody-drug conjugate (NDC) targeting CD73, a method for preparing same, and use thereof are provided. The monoclonal nanobody and the corresponding NDC can efficiently bind to isolated CD73, various tumor cells and CD73 on the surface of an immune cell with high specificity and block the catalytic activity of CD73 enzymes, exhibiting high affinity, low immunogenicity, and a significant anti-tumor effect.

Abstract: A tissue factor (TF)-targeted antibody-drug conjugate (ADC) and a method for preparing the ADC. The ADC is capable of binding to TF antigen with high specificity, and has high affinity, low immunogenicity, high cytotoxicity, and significant anti-tumor activity.

Abstract: Methods and systems for streaming content are disclosed. A manifest request is received from a streaming video player. A stitcher service generates the requested manifest, comprising primary content locators for corresponding segments of primary content, a placeholder for a secondary content pod, and an indication as to when the secondary content pod is to be played. The manifest is transmitted to the video player. A session identifier indicating a time to a next secondary content pod is placed on an asynchronous bus and is accessed by a session service. The session service generates a secondary content pod request which is accessed by a secondary content pod service. One or more secondary content pod decisions are generated. A request for a secondary content pod file is received from the video player. The secondary content pod file, comprising locators for items of secondary content is generated and provided to the video player.

Abstract: Disclosed by the present invention are a targeted CD73 antibody and an antibody-drug conjugate (ADC), and a preparation method therefor and application thereof. Further disclosed is a method for preparing the described monoclonal antibody and ADC. The monoclonal antibody and the corresponding ADC disclosed by the present invention can be efficiently and highly specifically combined with purified CD73 protein and CD73 on the surfaces of multiple tumor cells to block the catalytic activity of CD73 enzyme, and have high affinity, low immunogenicity and significant anti-tumor effect.

Abstract: Disclosed are a new AXL-targeting monoclonal antibody and antibody-drug conjugate. Also disclosed is a method for preparing said antibody and antibody-drug conjugate. The AXL antibody of the present invention can bind with purified human AXL protein and multiple AXL on tumor cell surface with high effectiveness and high specificity. Said humanized antibody also has high affinity and low immunogenicity. Said AXL antibody-drug conjugate has markable performance against tumors having high AXL expression.

Abstract: A tissue factor (TF)-targeted antibody-drug conjugate (ADC) and a method for preparing the ADC. The ADC is capable of binding to TF antigen with high specificity, and has high affinity, low immunogenicity, high cytotoxicity, and significant anti-tumor activity.

Abstract: The present disclosure relates to image processing. The method includes acquiring at least one of a backward propagation feature of an (x+1)th video frame in a video segment or a forward propagation feature of an (x?1)th video frame in the video segment. The video segment includes N video frames, N being an integer greater than 2, and x being an integer. The method further includes deriving a reconstruction feature of the xth video frame from at least one of the xth video frame, the backward propagation feature of the (x+1)th video frame, or the forward propagation feature of the (x?1)th video frame, and deriving a target video frame corresponding to the xth video frame by reconstructing the xth video frame based on the reconstruction feature of the xth video frame. The target video frame has resolution higher than that of the xth video frame.

Abstract: A tissue factor (TF)-targeted antibody-drug conjugate (ADC) and a method for preparing the ADC. The ADC is capable of binding to TF antigen with high specificity, and has high affinity, low immunogenicity, high cytotoxicity, and significant anti-tumor activity.

Abstract: A method for image restoration, an electronic device and a computer storage medium are provided. The method includes that: region division is performed on an acquired image to obtain more than one sub-image; each sub-image is input into multiple paths of neural network and restored by using a restoration network determined for each sub-image; a restored image of each sub-image is output and obtained, so as to obtain a restored image of the acquired image.

Abstract: An image processing method includes: acquiring an image frame sequence, including a to-be-processed image frame and one or more image frames adjacent thereto, and performing image alignment on the to-be-processed image frame and each of image frames in the image frame sequence to obtain multiple pieces of aligned feature data; determining, based on the multiple pieces of alignment feature data, multiple similarity features each between a respective one of the multiple pieces of aligned feature data and aligned feature data corresponding to the to-be-processed image frame, and determining weight information of each of multiple pieces of aligned feature data based on the multiple similarity features; and fusing the multiple pieces of aligned feature data according to the weight information to obtain fusion information of the image frame sequence, the fusion information being configured to acquire a processed image frame corresponding to the to-be-processed image frame.

Abstract: Disclosed are a new AXL-targeting monoclonal antibody and antibody-drug conjugate. Also disclosed is a method for preparing said antibody and antibody-drug conjugate. The AXL antibody of the present invention can bind with purified humanAXL protein and multiple AXL on tumor cell surface with high effectiveness and high specificity. Said humanized antibody also has high affinity and low immunogenicity. Said AXL antibody-drug conjugate has markable performance against tumors having high AXL expression.

Abstract: Disclosed by the present invention are a targeted CD73 antibody and an antibody-drug conjugate (ADC), and a preparation method therefor and application thereof. Further disclosed is a method for preparing the described monoclonal antibody and ADC. The monoclonal antibody and the corresponding ADC disclosed by the present invention can be efficiently and highly specifically combined with purified CD73 protein and CD73 on the surfaces of multiple tumor cells to block the catalytic activity of CD73 enzyme, and have high affinity, low immunogenicity and significant anti-tumor effect.

Abstract: The present invention provides a tissue factor (TF) monoclonal antibody and a preparation method therefor. The monoclonal antibody provided by the present invention can specifically bind with a TF antigen, has high affinity and low immunogenicity, and has the activity of resisting tumors and the like.

Abstract: A tissue factor (TF)-targeted antibody-drug conjugate (ADC) and a method for preparing the ADC. The ADC is capable of binding to TF antigen with high specificity, and has high affinity, low immunogenicity, high cytotoxicity, and significant anti-tumor activity.

Abstract: The present invention provides a tissue factor (TF) monoclonal antibody and a preparation method therefor. The monoclonal antibody provided by the present invention can specifically bind with a TF antigen, has high affinity and low immunogenicity, and has the activity of resisting tumors and the like.

Abstract: Systems, apparatus and methods are described related to context aware power management for graphics devices.

Abstract: Methods, systems, and computer program products that automatically categorize and/or assign ratings to content (video and audio content) uploaded by individuals who want to broadcast the content to others via a communications network, such as an IPTV network, are provided. When an individual uploads content to a network, a network service automatically extracts an audio stream from the uploaded content. Words in the extracted audio stream are identified. For each identified word, a preexisting library of selected words is queried to determine if a match exists between words in the library and words in the extracted audio stream. The selected words in the library are associated with a particular content category or content rating. If a match exists between an identified word and a word in the library, the uploaded content is assigned a content category and/or rating associated with the matched word.

Abstract: Devices and methods for obtaining media stream with adaptive resolutions. The device includes a receiver in communication with a processor, and a transmitter. The receiver is configured to receive a plurality of media signals. The processor is programmed to communicate with a terminal device in the home network, obtain a corresponding display resolution of the terminal device, and select a media signal according to the corresponding display resolution of the terminal device and a video resolution of the media signal. The transmitter is configured to transmit media stream corresponding to the selected media signal to the terminal device.

Abstract: A system that incorporates teachings of the present disclosure may include, for example, a controller configured to obtain information associated with media content, to generate a first group of tones representative of the information associated with the media content, and to generate a media stream comprising the media content and the first group of tones; and a communication interface configured to transmit the media stream to a media device whereby the media device presents the media content and a sequence of tones, where the sequence of tones is generated based at least in part on the first group of tones, where the first group of tones comprises high frequency tones and low frequency tones, and where one of the high and low frequency tones represents a binary one and the other of the high and low frequency tones represents a binary zero. Other embodiments are disclosed.