Abstract: Aspects of the disclosure include a fabrication platform for supporting a bioprinted fiber structures during printing, patterning, and/or processing, comprising a frame with a plurality of posts for securing a cross-linkable fiber during printing thereof, and where a continuous length of the cross-linkable fiber is printed around a plurality of posts during the 3D bioprinting process. The fabrication platform enables the cross-linkable fiber to be suspended during one or more of printing, patterning, and/or processing. In this way, the bioprinted fiber structure comprises a uniform outer surface, and can be easily modified and/or further processed after printing and patterning are completed.

Abstract: Aspects of the disclosure include a pump assembly comprising a plurality of pumps (e.g. syringe pumps) positioned in a radial array on a mounting bracket. In embodiments, each syringe pump of the plurality of syringe pumps comprises a housing comprising a syringe retainer and a plunger driver. The pump assembly serves to minimize internal volume when used as part of a multi-channel microfluidic bioprinting system.

Abstract: A print head for a three-dimensional printer, which in one embodiment includes a multi-channel enclosure comprising a core channel outlet, a first shell channel outlet, and a first fluidic focusing chamber converging toward a dispensing channel, with the core channel outlet in a central region of the enclosure, and the core and shell channels extending a respective depth into the enclosure. In another embodiment a plurality of shell channels includes an inner shell channel extending a greater length into the focusing chamber than an outer shell channel, and a core channel extends a greater length into the focusing chamber than any shell channel. In another embodiment, each of the core and first shell channels includes at least two inlet sub-channels having distinct fluid reservoirs, input orifices and control valves, which converge to form a single outlet in communication with a respective focusing chamber. A sheath flow channel may be provided.

Abstract: There is described a sample holder and associated fluid container assembly for optical analysis of a fluid sample within a translucent container of the fluid container assembly. The sample holder includes clamping members rotatably mounted to a frame for rotation, about parallel axes spaced apart from each other, between a container accepting position in which the clamping members are spaced apart from the translucent container, and an analysis position in the clamping members abut the translucent container. The clamping members each define an optical waveguide slot extending therethrough that is substantially aligned with the translucent container when the clamping members are disposed in the analysis position, to thereby provide optical access to the translucent container for optical analysis of the fluid sample therein.

Abstract: There is described a sample holder and associated fluid container assembly for optical analysis of a fluid sample within a translucent container of the fluid container assembly. The sample holder includes clamping members rotatably mounted to a frame for rotation, about parallel axes spaced apart from each other, between a container accepting position in which the clamping members are spaced apart from the translucent container, and an analysis position in the clamping members abut the translucent container. The clamping members each define an optical waveguide slot extending therethrough that is substantially aligned with the translucent container when the clamping members are disposed in the analysis position, to thereby provide optical access to the translucent container for optical analysis of the fluid sample therein.

Abstract: A sample holder holds various sizes of capillaries or cuvettes for use in dynamic light scattering (DLS) or quasi-elastic light scattering (QELS), such as in DLS of fluid samples such as platelet solutions, whole blood, colloids or the like. The sample holder has a base with a stationary backing member and a sliding, rail-mounted clamping member that is magnetically biased toward the backing member. The sample holder has Peltier-type thermoelectric heating/cooling elements that extend the full height of the clamping and backing members to optimize heat transfer efficiency. The sample holder further includes horizontal slots that enable collection of scattered light from various angles around the device. Finned heat sinks are mounted above and below the horizontal slots on the outwardly facing surfaces of the backing and clamping members to stabilize the temperature of the fluid sample in the sample holder without interfering with incident or scattered light.

Abstract: A sample holder holds various sizes of capillaries or cuvettes for use in dynamic light scattering (DLS) or quasi-elastic light scattering (QELS), such as in DLS of fluid samples such as platelet solutions, whole blood, colloids or the like. The sample holder has a base with a stationary backing member and a sliding, rail-mounted clamping member that is magnetically biased toward the backing member. The sample holder has Peltier-type thermoelectric heating/cooling elements that extend the full height of the clamping and backing members to optimize heat transfer efficiency. The sample holder further includes horizontal slots that enable collection of scattered light from various angles around the device. Finned heat sinks are mounted above and below the horizontal slots on the outwardly facing surfaces of the backing and clamping members to stabilize the temperature of the fluid sample in the sample holder without interfering with incident or scattered light.