Patents by Inventor Keelung Hong

Keelung Hong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical compositions to reduce complications of ocular steroid
    Patent number: 10286076
    Abstract: The present invention relates to pharmaceutical compositions comprising a combination of a lipid cake mixture comprising one or more phospholipids, with or without cholesterol, and a steroid solution comprising an ocular steroid, derivative thereof, a pharmaceutically acceptable salt thereof or a prodrug thereof, wherein the total amount of the phospholipid in the said composition is about 0.1 umol to less than about 2.5 umol per 50 ul of pharmaceutical composition and the side effects of the ocular steroid are reduced. The pharmaceutical composition is preferably administered by ocular route to treat ophthalmic diseases.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: May 14, 2019
    Assignees: TAIWAN LIPOSOME COMPANY, LTD., TLC BIOPHARMACEUTICALS, INC.
    Inventors: Keelung Hong, Luke S. S. Guo, Sheue-Fang Shih, Po-Chun Chang, Chih-Chiang Tsai, Hong-Hul Lin, Yun-Long Tseng
  • Pharmaceutical compositions to reduce complications of ocular steroid
    Patent number: 10058616
    Abstract: The present invention relates to pharmaceutical compositions comprising a combination of a lipid cake mixture comprising one or more phospholipids, with or without cholesterol, and a steroid solution comprising an ocular steroid, derivative thereof a pharmaceutically acceptable salt thereof or a prodrug thereof, wherein the total amount of the phospholipid in the said composition is about 0.1 umol to less than about 2.5 umol per 50 ul of pharmaceutical composition and the side effects of the ocular steroid are reduced. The pharmaceutical composition is preferably administered by ocular route to treat ophthalmic diseases.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: August 28, 2018
    Assignees: TLC BIOPHARMACEUTICALS, INC., TAIWAN LIPOSOME COMPANY, LTD.
    Inventors: Keelung Hong, Luke S. S. Guo, Sheue-Fang Shih, Po-Chun Chang, Chih-Chiang Tsai, Hong-Hul Lin, Yun-Long Tseng
  • LIPOSOMES USEFUL FOR DRUG DELIVERY
    Publication number: 20180235954
    Abstract: The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provide methods of making the liposome compositions provided by the present invention.
    Type: Application
    Filed: February 14, 2018
    Publication date: August 23, 2018
    Inventors: Keelung Hong, Daryl C. Drummond, Dmitri Kirpotin
  • PHARMACEUTICAL COMPOSITIONS TO REDUCE COMPLICATIONS OF OCULAR STEROID
    Publication number: 20180193461
    Abstract: The present invention relates to pharmaceutical compositions comprising a combination of a lipid cake mixture comprising one or more phospholipids, with or without cholesterol, and a steroid solution comprising an ocular steroid, derivative thereof, a pharmaceutically acceptable salt thereof or a prodrug thereof, wherein the total amount of the phospholipid in the said composition is about 0.1 umol to less than about 2.5 umol per 50 ul of pharmaceutical composition and the side effects of the ocular steroid are reduced. The pharmaceutical composition is preferably administered by ocular route to treat ophthalmic diseases.
    Type: Application
    Filed: March 6, 2018
    Publication date: July 12, 2018
    Inventors: Keelung Hong, Luke S. S. Guo, Sheue-Fang Shih, Po-Chun Chang, Chih-Chiang Tsai, Hong-Hul Lin, Yun-Long Tseng
  • Ophthalmic Drug Delivery System Containing Phospholipid and Cholesterol
    Publication number: 20180169248
    Abstract: An ophthalmic drug delivery system that contains phospholipid and cholesterol for prolonging drug lifetime in the eyes.
    Type: Application
    Filed: February 5, 2018
    Publication date: June 21, 2018
    Inventors: SHEUE-FANG SHIH, PO-CHUN CHANG, YUN-LONG TSENG, LUKE S.S. GUO, KEELUNG HONG
  • LIPOSOMES USEFUL FOR DRUG DELIVERY
    Publication number: 20180169014
    Abstract: The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provide methods of making the liposome compositions provided by the present invention.
    Type: Application
    Filed: February 14, 2018
    Publication date: June 21, 2018
    Inventors: Keelung Hong, Daryl C. Drummond, Dmitri Kirpotin
  • Ophthalmic drug delivery system containing phospholipid and cholesterol
    Patent number: 9987360
    Abstract: An ophthalmic drug delivery system that contains phospholipid and cholesterol for prolonging drug lifetime in the eyes.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: June 5, 2018
    Assignees: TAIWAN LIPOSOME CO. LTD., TLC BIOPHARMACEUTICALS, INC.
    Inventors: Sheue-Fang Shih, Po-Chun Chang, Yun-Long Tseng, Luke S. S. Guo, Keelung Hong
  • METHODS OF TREATING ARTHRITIS
    Publication number: 20170367979
    Abstract: The present invention provides methods of treating arthritis. A sustained release composition comprising liposomes and one or more therapeutic agent or a pharmaceutically acceptable salt thereof is administered to a subject in need thereof. The liposomes may be in an aqueous suspension. The sustained release composition can be administered intraarticularly.
    Type: Application
    Filed: September 5, 2017
    Publication date: December 28, 2017
    Inventors: KEELUNG HONG, LUKE S. S. GUO, YUN-LONG TSENG, SHEUE-FANG SHIH, PO-CHUN CHANG, CHIH-CHIANG TSAI, HONG-HUI LIN
  • Liposomes Useful for Drug Delivery
    Publication number: 20170340624
    Abstract: The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provide methods of making the liposome compositions provided by the present invention.
    Type: Application
    Filed: July 31, 2017
    Publication date: November 30, 2017
    Inventors: Keelung Hong, Daryl C. Drummond, Dmitri Kirpotin
  • Methods of treating arthritis
    Patent number: 9789062
    Abstract: The present invention provides methods of treating arthritis. A sustained release composition comprising liposomes and one or more therapeutic agent or a pharmaceutically acceptable salt thereof is administered to a subject in need thereof. The liposomes may be in an aqueous suspension. The sustained release composition can be administered intraarticularly.
    Type: Grant
    Filed: July 5, 2013
    Date of Patent: October 17, 2017
    Assignees: TLC BIOPHARMACEUTICALS, INC., TAIWAN LIPOSOME COMPANY, LTD.
    Inventors: Keelung Hong, Luke S. S. Guo, Yun-Long Tseng, Sheue-Fang Shih, Po-Chun Chang, Chih-Chiang Tsai, Hong-Hui Lin
  • Liposomes useful for drug delivery
    Patent number: 9782349
    Abstract: The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provide methods of making the liposome compositions provided by the present invention.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: October 10, 2017
    Assignee: Ipsen Biopharma Ltd.
    Inventors: Keelung Hong, Daryl C. Drummond, Dmitri Kirpotin
  • Liposomes useful for drug delivery
    Patent number: 9730891
    Abstract: The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provide methods of making the liposome compositions provided by the present invention.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: August 15, 2017
    Assignee: IPSEN BIOPHARM LTD.
    Inventors: Keelung Hong, Daryl C. Drummond, Dmitri Kirpotin
  • Liposomes useful for drug delivery
    Patent number: 9724303
    Abstract: The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provide methods of making the liposome compositions provided by the present invention.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: August 8, 2017
    Assignee: IPSEN BIOPHARM LTD.
    Inventors: Keelung Hong, Daryl C. Drummond, Dmitri Kirpotin
  • Liposomes useful for drug delivery
    Patent number: 9717723
    Abstract: The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provides methods of making the liposome compositions provided by the present invention.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: August 1, 2017
    Assignee: IPSEN BIOPHARM LTD.
    Inventors: Keelung Hong, Daryl C. Drummond, Dmitri Kirpotin
  • Liposomes Useful for Drug Delivery
    Publication number: 20170079913
    Abstract: The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provide methods of making the liposome compositions provided by the present invention.
    Type: Application
    Filed: November 29, 2016
    Publication date: March 23, 2017
    Inventors: Keelung Hong, Daryl C. Drummond, Dmitri Kirpotin
  • Liposomes Useful for Drug Delivery
    Publication number: 20170079914
    Abstract: The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provide methods of making the liposome compositions provided by the present invention.
    Type: Application
    Filed: November 29, 2016
    Publication date: March 23, 2017
    Inventors: Keelung Hong, Daryl C. Drummond, Dmitri Kirpotin
  • Liposomes Useful for Drug Delivery
    Publication number: 20170079912
    Abstract: The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provide methods of making the liposome compositions provided by the present invention.
    Type: Application
    Filed: November 29, 2016
    Publication date: March 23, 2017
    Inventors: Keelung Hong, Daryl C. Drummond, Dmitri Kirpotin
  • Liposomes Useful for Drug Delivery
    Publication number: 20170071858
    Abstract: The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provide methods of making the liposome compositions provided by the present invention.
    Type: Application
    Filed: November 29, 2016
    Publication date: March 16, 2017
    Inventors: Keelung Hong, Daryl C. Drummond, Dmitri Kirpotin
  • Liposomes Useful for Drug Delivery
    Publication number: 20160339014
    Abstract: The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provide methods of making the liposome compositions provided by the present invention.
    Type: Application
    Filed: August 3, 2016
    Publication date: November 24, 2016
    Inventors: Keelung Hong, Daryl C. Drummond, Dmitri Kirpotin
  • Liposomes Useful for Drug Delivery
    Publication number: 20160338956
    Abstract: The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provide methods of making the liposome compositions provided by the present invention.
    Type: Application
    Filed: August 3, 2016
    Publication date: November 24, 2016
    Inventors: Keelung Hong, Daryl C. Drummond, Dmitri Kirpotin