Abstract: A grating structure, a diffraction optical waveguide, and a display device are disclosed. The grating line of the grating structure has a cross-sectional profile with a narrow top and a wide bottom, wherein the cross-sectional profile comprises six feature points, and the six feature points respectively have coordinates (0, 0), (L2, H2), (L3, H3), (L4, H4), (L5, H5) and (L6, 0) in a cross section, and satisfy following relationships: Hdrop=min(H4,H5)?max(H3,H2)>50 nm; 0.1<(L5?L4)/(L3?L2); L3>0.34T; and 0.05T<L5?L4<0.32T. By controlling the parameters of these feature points, the cross-sectional profile can be adjusted, and thus significantly improving the optical effect (comprising diffraction efficiency and uniformity) that the grating structure can achieve, and at the same time increasing degrees of freedom in grating design and optical effect regulation.

Abstract: Genetic circuits that control transgene expression in response to pre-defined transcriptional cues would enable the development of smart therapeutics. The present disclosure relates to engineered programmable single-transcript RNA sensors in which adenosine deaminases acting on RNA (ADARs) autocatalytically convert trigger hybridization into a translational output. This system amplifies the signal from editing by endogenous ADAR through a positive feedback loop. Amplification is mediated by the expression of a hyperactive, minimal ADAR variant and its recruitment to the edit site via an orthogonal RNA targeting mechanism. This topology confers high dynamic range, low background, minimal off-target effects, and a small genetic footprint. The circuits and systems disclosed herein leverage an ability to detect single nucleotide polymorphisms and modulate translation in response to endogenous transcript levels in mammalian cells.

Abstract: A method and apparatus for multi-source content blending.