Abstract: Compounds of Formula (I) or (Ia) or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds of Formula (I) or (Ia) or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.

Abstract: Compounds or their pharmaceutically acceptable salts can inhibit the G12C mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds disclosed herein or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.

Abstract: A light-emitting device according to an embodiment of the present disclosure includes: a substrate having a first surface and a second surface that are opposed to each other; a plurality of light-emitting elements arranged in an array on the first surface side of the substrate; a partition wall formed above the plurality of light-emitting elements using a metal material and having an opening for each of the plurality of light-emitting elements; and a wavelength conversion layer that is provided in the opening and converts a wavelength of light outputted from the plurality of light-emitting elements.

Abstract: A radiological image conversion panel 2 is provided with a phosphor 18 containing a fluorescent material that emits fluorescence by radiation exposure, in which the phosphor includes, a columnar section 34 formed by a group of columnar crystals which are obtained through columnar growth of crystals of the fluorescent material, and a non-columnar section 36, the columnar section and the non-columnar section are integrally formed to overlap in a crystal growth direction of the columnar crystals, and a thickness of the non-columnar section along the crystal growth direction is non-uniform in a region of at least a part of the non-columnar section.

Abstract: A lighting system includes: a luminaire; a brightness sensor that controls the luminaire via wireless communication and detects brightness of the luminaire; a controller that performs control of the luminaire via the brightness sensor; and an operation terminal. The operation terminal wirelessly transmits setting information related to the control of the luminaire to the brightness sensor, and the brightness sensor relays the setting information to the controller via wired communication.

Abstract: A lighting system includes: a luminaire; a brightness sensor that controls the luminaire via wireless communication and detects brightness of the luminaire; a controller that performs control of the luminaire via the brightness sensor; and an operation terminal. The operation terminal wirelessly transmits setting information related to the control of the luminaire to the brightness sensor, and the brightness sensor relays the setting information to the controller via wired communication.

Abstract: A radiological image conversion panel 2 is provided with a phosphor 18 containing a fluorescent material that emits fluorescence by radiation exposure, in which the phosphor includes, a columnar section 34 formed by a group of columnar crystals which are obtained through columnar growth of crystals of the fluorescent material, and a non-columnar section 36, the columnar section and the non-columnar section are integrally formed to overlap in a crystal growth direction of the columnar crystals, and a thickness of the non-columnar section along the crystal growth direction is non-uniform in a region of at least a part of the non-columnar section.

Abstract: A radiological image conversion panel 2 is provided with a phosphor 18 containing a fluorescent material that emits fluorescence by radiation exposure, in which the phosphor includes, a columnar section 34 formed by a group of columnar crystals which are obtained through columnar growth of crystals of the fluorescent material, and a non-columnar section 36, the columnar section and the non-columnar section are integrally formed to overlap in a crystal growth direction of the columnar crystals, and a thickness of the non-columnar section along the crystal growth direction is non-uniform in a region of at least a part of the non-columnar section.

Abstract: A sensor control device which controls: a first sensor which detects, based on a captured image, whether a person is present in a first detection range, and detects, for each of regions into which the first detection range is divided, whether a person is present in the region, based on a captured image; and a plurality of second sensors which detect, based on infrared radiation, whether a person is present in respective second detection ranges includes a determiner which matches, for each of the regions, an on or off state of a detection function of the first sensor in the region with an on or off state of a detection function of a second sensor whose second detection range overlaps the region, among the plurality of second sensors, by controlling the first sensor and the plurality of second sensors.

Abstract: A detection device includes: a first sensor which detects, based on a captured image, whether a person is present in a first detection range; a plurality of second sensors which are disposed around the first sensor, and detect, based on infrared radiation, whether a person is present in respective second detection ranges each of which overlaps at least a portion of the first detection range; and at least one hood which blocks part of infrared radiation directed to at least one of the plurality of second sensors, to reduce a non-overlapping portion of a combined detection range of the first detection range of the first sensor and the second detection ranges of the plurality of second sensors, the non-overlapping portion being a portion in which the first detection range and the second detection ranges do not overlap.

Abstract: A sensor control device includes: a determiner which has a first determination mode for determining whether a person is present, based on a result of detection by a first sensor and a result of detection by a second sensor, and a second determination mode for determining whether a person is present, based on a result of detection by the second sensor, wherein the determiner suspends determination as to whether a person is present in the first determination mode, if a brightness change value indicating a change in brightness in a first detection range during a certain time period is greater than a predetermined value in the first determination mode, and determines whether a person is present in the first determination mode, if the brightness change value in the first detection range is less than the predetermined value in the first determination mode.

Abstract: A dimming device includes: a communication unit to receive a control signal for controlling a lighting state of an illumination load; a dimming circuit to dim the illumination load; a dimming circuit driving unit to control the dimming circuit to change a dimming level of the illumination load in response to the control signal; a relay connected between the illumination load and the dimming circuit; a relay driving unit to control on/off of the relay according to the control signal; a measurement unit configured to measure a load state of the illumination load and a control unit to cause the notification unit to notify the overload state, when it is determined by the measurement unit that the illumination load is in the overload state.

Abstract: A sensor control device includes: a determiner which has a first determination mode for determining whether a person is present, based on a result of detection by a first sensor and a result of detection by a second sensor, and a second determination mode for determining whether a person is present, based on a result of detection by the second sensor, wherein the determiner suspends determination as to whether a person is present in the first determination mode, if a brightness change value indicating a change in brightness in a first detection range during a certain time period is greater than a predetermined value in the first determination mode, and determines whether a person is present in the first determination mode, if the brightness change value in the first detection range is less than the predetermined value in the first determination mode.

Abstract: A detection device includes: a first sensor which detects, based on a captured image, whether a person is present in a first detection range; a plurality of second sensors which are disposed around the first sensor, and detect, based on infrared radiation, whether a person is present in respective second detection ranges each of which overlaps at least a portion of the first detection range; and at least one hood which blocks part of infrared radiation directed to at least one of the plurality of second sensors, to reduce a non-overlapping portion of a combined detection range of the first detection range of the first sensor and the second detection ranges of the plurality of second sensors, the non-overlapping portion being a portion in which the first detection range and the second detection ranges do not overlap.

Abstract: A sensor control device which controls: a first sensor which detects, based on a captured image, whether a person is present in a first detection range, and detects, for each of regions into which the first detection range is divided, whether a person is present in the region, based on a captured image; and a plurality of second sensors which detect, based on infrared radiation, whether a person is present in respective second detection ranges includes a determiner which matches, for each of the regions, an on or off state of a detection function of the first sensor in the region with an on or off state of a detection function of a second sensor whose second detection range overlaps the region, among the plurality of second sensors, by controlling the first sensor and the plurality of second sensors.

Abstract: A radiological image conversion panel 2 is provided with a phosphor 18 containing a fluorescent material that emits fluorescence by radiation exposure, in which the phosphor includes, a columnar section 34 formed by a group of columnar crystals which are obtained through columnar growth of crystals of the fluorescent material, and a non-columnar section 36, the columnar section and the non-columnar section are integrally formed to overlap in a crystal growth direction of the columnar crystals, and a thickness of the non-columnar section along the crystal growth direction is non-uniform in a region of at least a part of the non-columnar section.

Abstract: A radiological image conversion panel 2 is provided with a phosphor 18 containing a fluorescent material that emits fluorescence by radiation exposure, in which the phosphor includes, a columnar section 34 formed by a group of columnar crystals which are obtained through columnar growth of crystals of the fluorescent material, and a non-columnar section 36, the columnar section and the non-columnar section are integrally formed to overlap in a crystal growth direction of the columnar crystals, and a thickness of the non-columnar section along the crystal growth direction is non-uniform in a region of at least a part of the non-columnar section.

Abstract: A dimming device includes: a communication unit to receive a control signal for controlling a lighting state of an illumination load; a dimming circuit to dim the illumination load; a dimming circuit driving unit to control the dimming circuit to change a dimming level of the illumination load in response to the control signal; a relay connected between the illumination load and the dimming circuit; a relay driving unit to control on/off of the relay according to the control signal; a measurement unit configured to measure a load state of the illumination load and a control unit to cause the notification unit to notify the overload state, when it is determined by the measurement unit that the illumination load is in the overload state.

Abstract: A radiological image conversion panel 2 provided with a support 11 and a phosphor 18 which is formed on the support and contains a fluorescent material that emits fluorescence by radiation exposure. The phosphor includes a columnar section 34 formed by a group of columnar crystals which are obtained through columnar growth of crystals of the fluorescent material, and a non-columnar section 36. The columnar section and the non-columnar section are integrally formed to overlap in a crystal growth direction of the columnar crystals, and a porosity at the columnar section side of the non-columnar section is higher than a porosity at the support side of the non-columnar section.

Abstract: The device includes: a scintillator 200 configured to emit fluorescence by irradiation of radiation, and a photodetector 40 configured to detect the fluorescence emitted from the scintillator 200 as an electrical signal, wherein the scintillator 200 includes a columnar section 20 which is disposed at a rear side of the photodetector 40 in a travel direction of the radiation and at the same time is formed by a group of columnar crystals 20A obtained through columnar growth of crystals of a fluorescent material, and a first non-columnar section 23 which is provided at the photodetector 40 side of the columnar section 20.