Patents by Inventor Keietsu Abe
Keietsu Abe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11946086Abstract: This invention is intended to identify a gene cluster involved in biosynthesis of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species and to establish a system for synthesizing such cyclic peptide compound. The gene is composed of a first module to a tenth module and encodes a protein having activity of synthesizing a nonribosomal peptide constituting a basic peptide backbone of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species.Type: GrantFiled: December 13, 2021Date of Patent: April 2, 2024Assignees: TOHOKU UNIVERSITY, KUMIAI CHEMICAL INDUSTRY CO., LTD.Inventors: Takashi Kubo, Masayuki Machida, Maiko Umemura, Keietsu Abe, Akira Yoshimi, Tomonori Fujioka, Shigenari Yamaguchi, Kiyoshi Kawai
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Publication number: 20220259634Abstract: This invention is intended to identify a gene cluster involved in biosynthesis of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species and to establish a system for synthesizing such cyclic peptide compound. The gene is composed of a first module to a tenth module and encodes a protein having activity of synthesizing a nonribosomal peptide constituting a basic peptide backbone of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species.Type: ApplicationFiled: December 13, 2021Publication date: August 18, 2022Applicants: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, TOHOKU UNIVERSITY, KUMIAI CHEMICAL INDUSTRY CO., LTD.Inventors: Takashi KUBO, Masayuki MACHIDA, Maiko UMEMURA, Keietsu ABE, Akira YOSHIMI, Tomonori FUJIOKA, Shigenari YAMAGUCHI, Kiyoshi KAWAI
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Patent number: 11230726Abstract: This invention is intended to identify a gene cluster involved in biosynthesis of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species and to establish a system for synthesizing such cyclic peptide compound. The gene is composed of a first module to a tenth module and encodes a protein having activity of synthesizing a nonribosomal peptide constituting a basic peptide backbone of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species.Type: GrantFiled: December 27, 2017Date of Patent: January 25, 2022Assignees: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, TOHOKU UNIVERSITY, KUMIAI CHEMICAL INDUSTRY CO., LTD.Inventors: Takashi Kubo, Masayuki Machida, Maiko Umemura, Keietsu Abe, Akira Yoshimi, Tomonori Fujioka, Shigenari Yamaguchi, Kiyoshi Kawai
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Patent number: 11021725Abstract: Provided is a mutant filamentous fungus, which lacks expression of ?-1,3-glucan, and is deficient in at least part of a GAG biosynthetic cluster. Also provided is a method of producing a substance, including the steps of: culturing the filamentous fungus to allow the filamentous fungus to produce a substance; and collecting the resulting substance.Type: GrantFiled: May 1, 2018Date of Patent: June 1, 2021Assignees: TOHOKU UNIVERSITY, KANAZAWA INSTITUTE OF TECHNOLOGYInventors: Keietsu Abe, Akira Yoshimi, Ken Miyazawa, Fuka Tabata, Katsuya Gomi, Motoaki Sano
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Patent number: 11015175Abstract: An object to be achieved by the present invention is to culture a filamentous fungus at a high density, thereby enabling mass production of a useful substance. The present invention provides a method of producing a substance, including the steps of: culturing a mutant filamentous fungus with no expression of ?-1,3-glucan to allow the filamentous fungus to produce a substance; and collecting the resulting substance.Type: GrantFiled: November 8, 2013Date of Patent: May 25, 2021Assignee: TOHOKU UNIVERSITYInventors: Keietsu Abe, Katsuya Gomi, Kei Yoshimi
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Publication number: 20200115726Abstract: Provided is a mutant filamentous fungus, which lacks expression of ?-1,3-glucan, and is deficient in at least part of a GAG biosynthetic cluster. Also provided is a method of producing a substance, including the steps of: culturing the filamentous fungus to allow the filamentous fungus to produce a substance; and collecting the resulting substance.Type: ApplicationFiled: May 1, 2018Publication date: April 16, 2020Applicants: TOHOKU UNIVERSITY, KANAZAWA INSTITUTE OF TECHNOLOGYInventors: Keietsu ABE, Akira YOSHIMI, Ken MIYAZAWA, Fuka TABATA, Katsuya GOMI, Motoaki SANO
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Publication number: 20190316164Abstract: This invention is intended to identify a gene cluster involved in biosynthesis of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species and to establish a system for synthesizing such cyclic peptide compound. The gene is composed of a first module to a tenth module and encodes a protein having activity of synthesizing a nonribosomal peptide constituting a basic peptide backbone of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species.Type: ApplicationFiled: December 27, 2017Publication date: October 17, 2019Applicants: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, TOHOKU UNIVERSITY, KUMIAI CHEMICAL INDUSTRY CO., LTD.Inventors: Takashi KUBO, Masayuki MACHIDA, Maiko UMEMURA, Keietsu ABE, Akira YOSHIMI, Tomonori FUJIOKA, Shigenari YAMAGUCHI, Kiyoshi KAWAI
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Patent number: 9387175Abstract: It has been found that modification of surfaces of nanoparticles with a RolA protein decreases an immunostimulation activity of the nanoparticles on myeloid dendritic cells and also decreases phagocytosis of the nanoparticles by macrophages. The present invention provides nanoparticles being modified with a biological molecule and having an immune-response evasion function.Type: GrantFiled: August 3, 2012Date of Patent: July 12, 2016Assignee: TOHOKU UNIVERSITYInventors: Keietsu Abe, Kazuyoshi Kawakami, Tadafumi Ajiri, Manabu Fukumoto, Seiichi Takami, Takanari Togashi, Kimihide Muragaki, Toru Takahashi
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Publication number: 20150307852Abstract: An object to be achieved by the present invention is to culture a filamentous fungus at a high density, thereby enabling mass production of a useful substance. The present invention provides a method of producing a substance, including the steps of: culturing a mutant filamentous fungus with no expression of ?-1,3-glucan to allow the filamentous fungus to produce a substance; and collecting the resulting substance.Type: ApplicationFiled: November 8, 2013Publication date: October 29, 2015Applicant: TOHOKU UNIVERSITYInventors: Keietsu ABE, Katsuya GOMI, Kei YOSHIMI
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Publication number: 20140314859Abstract: It has been found that modification of surfaces of nanoparticles with a RolA protein decreases an immunostimulation activity of the nanoparticles on myeloid dendritic cells and also decreases phagocytosis of the nanoparticles by macrophages. The present invention provides nanoparticles being modified with a biological molecule and having an immune-response evasion function.Type: ApplicationFiled: August 3, 2012Publication date: October 23, 2014Applicant: TOHOKU UNIVERSITYInventors: Keietsu Abe, Kazuyoshi Kawakami, Tadafumi Ajiri, Manabu Fukumoto, Seiichi Takami, Takanari Togashi, Kimihide Muragaki, Toru Takahashi
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Publication number: 20120023616Abstract: This invention provides a method for preventing or inhibiting infection with a plant-infecting microorganism and imparting resistivity to plants, a method for preparing plants having resistance to diseases caused by microorganisms such as plant pathogenic filamentous fungi, and a microbial pesticide formulation. The method for preventing or inhibiting infection of a host plant with plant-infecting microorganisms comprises degrading ?-1,3-glucan on cell walls of the microorganisms by ?-1,3-glucanase.Type: ApplicationFiled: March 16, 2010Publication date: January 26, 2012Applicant: NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCESInventors: Marie Nishimura, Yoko Nishizawa, Takashi Fujikawa, Ichiro Mitsuhara, Eiichi Minami, Keietsu Abe, Takashi Tachiki, Shigekazu Yano
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Patent number: 7763444Abstract: It is intended to provide koji mold-origin phospholipase A2 and a DNA encoding it. Namely, phospholipase A2 comprising the following protein (a) or (b): (a) a protein having an amino acid sequence represented by SEQ ID NO: 1 or 2; and (b) a protein having an amino acid sequence derived from an amino acid sequence represented by SEQ ID NO: 1 or 2 by a partial modification and serving as phospholipase A2.Type: GrantFiled: June 23, 2009Date of Patent: July 27, 2010Assignees: National Institute of Technology and Evaluation, National Institute of Advanced Industrial Science and Technology, National Research Institute of BrewingInventors: Katsuhiko Kitamoto, Manabu Arioka, Shotaro Yamaguchi, Masayuki Machida, Keietsu Abe, Katsuya Gomi, Kiyoshi Asai, Motoaki Sano, Taishin Kin, Hideki Nagasaki, Akira Hosoyama, Osamu Akita, Naotake Ogasawara, Satoru Kuhara
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Publication number: 20090263888Abstract: It is intended to provide koji mold-origin phospholipase A2 and a DNA encoding it. Namely, phospholipase A2 comprising the following protein (a) or (b): (a) a protein having an amino acid sequence represented by SEQ ID NO: 1 or 2; and (b) a protein having an amino acid sequence derived from an amino acid sequence represented by SEQ ID NO: 1 or 2 by a partial modification and serving as phospholipase A2.Type: ApplicationFiled: June 23, 2009Publication date: October 22, 2009Applicants: National Institute of Technology and Evaluation, Natinal Institute of Advanced Industrial Science and Technology, National Research Institute of BrewingInventors: Katsuhiko Kitamoto, Manabu Arioka, Shotaro Yamaguchi, Masayuki Machida, Keietsu Abe, Katsuya Gomi, Kiyoshi Asai, Motoaki Sano, Taishin Kin, Hideki Nagasaki, Akira Hosoyama, Osamu Akita, Naotake Ogasawara, Satoru Kuhara
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Patent number: 7348170Abstract: Lysyl oxidase derived from filamentous fungi and a DNA encoding thereof are provided. Lysyl oxidase including a protein described in of the following (a) or (b): (a) a protein having an amino acid sequence set forth in SEQ ID NO: 2; or (b) a protein having an amino acid sequence obtained by modifying a part of the amino acid sequence set forth in SEQ ID NO: 2, and functioning as lysyl oxidase.Type: GrantFiled: December 25, 2002Date of Patent: March 25, 2008Assignees: Amano Enzyme Inc., National Institute of Advanced Industrial Science and Technology, National Institute of Technology and Evaluation, National Research Institute of BrewingInventors: Kensuke Yuuki, Atsuki Toumoto, Masayuki Machida, Keietsu Abe, Katsuya Gomi, Kiyoshi Asai, Motoaki Sano, Taishin Kin, Hideki Nagasaki, Akira Hosoyama, Osamu Akita, Naotake Ogasawara, Satoru Hisahara
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Patent number: 7285407Abstract: The purpose of the present invention is to isolate a gene encoding novel exo-, or endo-?-1,3-glucanase, to obtain a microorganism having an enhanced expression of said gene and to degrade ?-1,3-glucan to its low molecular weight form by means of said enzymes. The present invention relates to a gene or DNA encoding novel enzymes having ?-1,3-glucanase activity (exo-, or endo-?-1,3-glucanase), a recombinant expression vector comprising them, a microorganism having the recombinant expression vector, the novel enzymes having ?-1,3-glucanase activity, and a method for the production of said enzymes.Type: GrantFiled: March 22, 2005Date of Patent: October 23, 2007Assignees: National Institute of Advanced Industrial Science and Technology, National Institute of Technology and EvaluationInventors: Masayuki Machida, Motoaki Sano, Misao Sunagawa, Tasuku Nakajima, Keietsu Abe, Katsuya Gomi, Kiyoshi Asai, Taishin Kin, Hideki Nagasaki, Akira Hosoyama, Osamu Akita, Naotake Ogasawara, Satoru Kuhara
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Patent number: 7186540Abstract: A completely novel glutaminase is provided: (a) a protein consisting of an amino acid sequence represented by SEQ ID NO: 2, or (b) a protein consisting of an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 by deletion, substitution or addition of one or more amino acids, and possessing glutaminase activity. This protein is a novel glutaminase possessing excellent thermostability and the like.Type: GrantFiled: December 24, 2002Date of Patent: March 6, 2007Assignees: National Institute of Advanced Indusrtial Science and Technology, National Institute of Technology and Evaluation, National Research Institute of BrewingInventors: Masayuki Machida, Keietsu Abe, Katsuya Gomi, Kiyoshi Asai, Motoaki Sano, Taishin Kin, Hideki Nagasaki, Akira Hosoyama, Osamu Akita, Naotake Ogasawara, Satoru Kuhara, Kotaro Ito, Kenichiro Matsushima, Yasuji Koyama
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Publication number: 20060234320Abstract: The present invention provides DNA encoding novel pyroglutamyl peptidase derived from Aspergillus oryzae, pyroglutamyl peptidase which is produced by using the DNA, and a method for producing a protein lysate with a good flavor at a high hydrolysis rate.Type: ApplicationFiled: December 26, 2002Publication date: October 19, 2006Inventors: Masayuki Machida, Keietsu Abe, Katsuya Gomi, Kiyoshi Asai, Motoaki Sano, Taishin Kin, Hideki Nagasaki, Akira Hosoyama, Osamu Akita, Naotake Ogasawara, Satoru Kuhara, Chikara Tokunaga, Itaru Toda, Chiaki Saitoh, Akihiro Senoh
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Publication number: 20060106120Abstract: A method of degrading a plastic in the presence of a biosurfactant; a method of degrading a plastic by contacting the plastic with a microorganism; a process for producing a useful substance from a plastic which comprises degrading the plastic by contacting the plastic with a microorganism and further converting the components of the thus degraded plastic with the use of a microorganism; a method of degrading a plastic by contacting the plastic with a microorganism in the coexistence of a biosurfactant and/or a plastic-degrading enzyme and thus degrading the plastic under the action of the microorganism; a transformant microorganism having been recombined with at least one DNA selected from among a DNA containing a gene encoding a surface active substance, a DNA containing a gene encoding a plastic-degrading enzyme and a DNA containing a gene encoding a useful substance; novel genes as described above; and proteins encoded thereby.Type: ApplicationFiled: September 17, 2003Publication date: May 18, 2006Applicants: TOHOPKU TECHNO ARCH CO., LTD., National Institute of Advanced Industrial Science and TechnologyInventors: Keietsu Abe, Katsuya Gomi, Yohei Yamagata, Fumihiko Hasegawa, Hiroshi Maeda, Tasuku Nakajima, Masayuki Machida
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Publication number: 20050287634Abstract: The purpose of the present invention is to isolate a gene encoding novel exo-, or endo-?-1,3-glucanase, to obtain a microorganism having an enhanced expression of said gene and to degrade ?-1,3-glucan to its low molecular weight form by means of said enzymes. The present invention relates to a gene or DNA encoding novel enzymes having ?-1,3-glucanase activity (exo-, or endo-?-1,3-glucanase), a recombinant expression vector comprising them, a microorganism having the recombinant expression vector, the novel enzymes having ?-1,3-glucanase activity, and a method for the production of said enzymes.Type: ApplicationFiled: March 22, 2005Publication date: December 29, 2005Applicants: National Institute of advanced Industrial Science and Technology, National Institute of Technology and Evaluation, National Research Institute of BrewingInventors: Masayuki Machida, Motoaki Sano, Misao Sunagawa, Tasuku Nakajima, Keietsu Abe, Katsuya Gomi, Kiyoshi Asai, Taishin Kin, Hideki Nagasaki, Akira Hosoyama, Osamu Akita, Naotake Ogasawara, Satoru Kuhara
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Publication number: 20040082053Abstract: A completely novel glutaminase is provided: (a) a protein consisting of an amino acid sequence represented by SEQ ID NO: 2, or (b) a protein consisting of an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 by deletion, substitution or addition of one or more amino acids, and possessing glutaminase activity. This protein is a novel glutaminase possessing excellent thermostability and the like.Type: ApplicationFiled: December 24, 2002Publication date: April 29, 2004Inventors: Masayuki Machida, Keietsu Abe, Katsuya Gomi, Kiyoshi Asai, Motoaki Sano, Taishin Kin, Hideki Nagasaki, Akira Hosoyama, Osamu Akita, Naotake Ogasawara, Satoru Kuhara, Kotaro Ito, Kenichiro Matsushima, Yasuji Koyama