Abstract: A polymer included in a reagent layer of a sensor for measuring an analyte in a sample includes: a first binding site covalently bonded to a protein acting on the analyte; and a second binding site that binds to the protein by electrostatic interaction.

Abstract: The present invention forms a detection layer in an embedded biosensor probe by using a phenazine derivative as a redox mediator in which a phenazine group is covalently bonded to a high molecular weight polymer having a carboxyl group or an amino group, such as polyamino acid, polyimine, or polyallylamine; and the distance between the phenazine group and the high molecular weight polymer main chain is increased by using a polyethylene glycol chain.

Abstract: The present disclosure provides a means for preventing or suppressing the leaching of a redox mediator constituting a reagent layer in a probe of an embedded biosensor, in particular, a means capable of improving preservation stability (durability) while maintaining glucose measurement sensitivity. The high molecular weight redox polymer according to the present disclosure is represented by general formula (A1), wherein X? represents an anionic species; L represents a linker; Poly represents a high molecular weight polymer; and R1 to R8 each independently represent a hydrogen atom or a substituent. The biosensor according to the present disclosure has a working electrode, a counter electrode, a reagent layer disposed on the working electrode, and a protective film covering at least the reagent layer, and the reagent layer contains an oxidoreductase that oxidizes or dehydrogenates the analyte and at least one high molecular weight redox polymer represented by general formula (A1).

Abstract: Provided is a biological substance detection sensor used in an electrochemical measurement method and allowing high-precision measurement by reducing a blank current. A biological substance detection sensor of the present invention for analyzing a component in a testing solution using a mediator includes at least: an insulating substrate; a conductive part formed on a surface of the insulating substrate and including at least one pair of a working electrode and a counter electrode; and a reagent part disposed in contact with or in a vicinity of the conductive part and including at least one of protein and the mediator. The reagent part further includes at least one additive selected from the group consisting of a halide and/or a pseudo halide.

Abstract: The present invention forms a detection layer in an embedded biosensor probe by using a phenazine derivative as a redox mediator in which a phenazine group is covalently bonded to a high molecular weight polymer having a carboxyl group or an amino group, such as polyamino acid, polyimine, or polyallylamine; and the distance between the phenazine group and the high molecular weight polymer main chain is increased by using a polyethylene glycol chain.

Abstract: Provided is a catalase inhibitor comprising a compound represented by formula (I): wherein R1 to R4 independently represent a hydrogen atom, a halogen atom, an amino group, a hydroxyl group, a carbonyl group, or a hydrocarbon group having 1 to 4 carbon atoms, wherein the hydrocarbon group may have at least one substituent selected from the group consisting of a halogen atom, an amino group, a hydroxyl group and a carbonyl group; and X? represents an anionic chemical species.

Abstract: Provided is a catalase inhibitor comprising a compound represented by formula (I): wherein R1 to R4 independently represent a hydrogen atom, a halogen atom, an amino group, a hydroxyl group, a carbonyl group, or a hydrocarbon group having 1 to 4 carbon atoms, wherein the hydrocarbon group may have at least one substituent selected from the group consisting of a halogen atom, an amino group, a hydroxyl group and a carbonyl group; and X? represents an anionic chemical species.

Abstract: Provided are an oxidizing agent for an electron mediator, said oxidizing agent including a trivalent iodobenzene compound; an analyte measurement reagent including the oxidizing agent; a sensor supporting the oxidizing agent; and a method for the electrochemical measurement of an analyte using the oxidizing agent.

Abstract: A biosensor includes a base substrate; an electrode layer disposed on a main surface of the base substrate and including first and second electrode pairs, each pair including a working electrode and a counter electrode; a spacer substrate on the electrode layer and having first and openings, the first opening exposing a part of the first electrode pair and the second opening exposing a part of the second electrode pair; a first reagent layer containing a first reagent reactive with a sample and disposed in the first opening; a second reagent layer containing a second reagent reactive with the sample and disposed in the second opening; and a top cover substrate on the spacer substrate, the top cover substrate including an introduction portion having at least one introduction opening, the introduction portion overlapping a part of the first opening in the spacer substrate and a part of the second opening.