Patents by Inventor Keigo Kumagai

Keigo Kumagai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treating ectopic ossification or diffuse intrinsic pontine glioma in a subject by administering an anti-ALK2 antibody
    Patent number: 11859006
    Abstract: This application relates to a pharmaceutical composition for use in a method for treating and/or preventing a patient having ectopic ossification and/or brain tumor, wherein the patient has an active mutation in ALK2 protein which is responsible for ectopic ossification or brain tumor; an amino acid residue at position 330 of ALK2 is proline; and an active ingredient of this composition is an anti-ALK2 antibody or an antigen-binding fragment thereof comprising a property of binding to ALK2, a property of cross-linking ALK2, and a property of inhibiting BMP signal transduction.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: January 2, 2024
    Assignees: Saitama Medical University, Daiichi Sankyo Company, Limited
    Inventors: Takenobu Katagiri, Sho Tsukamoto, Keigo Kumagai, Shinnosuke Tsuji
  • PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING HETEROTOPIC OSSIFICATION
    Publication number: 20210009709
    Abstract: This application relates to a pharmaceutical composition for use in a method for treating and/or preventing a patient having ectopic ossification and/or brain tumor, wherein the patient has an active mutation in ALK2 protein which is responsible for ectopic ossification or brain tumor; an amino acid residue at position 330 of ALK2 is proline; and an active ingredient of this composition is an anti-ALK2 antibody or an antigen-binding fragment thereof comprising a property of binding to ALK2, a property of cross-linking ALK2, and a property of inhibiting BMP signal transduction.
    Type: Application
    Filed: March 4, 2019
    Publication date: January 14, 2021
    Applicants: SAITAMA MEDICAL UNIVERSITY, DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Takenobu KATAGIRI, Sho TSUKAMOTO, Keigo KUMAGAI, Shinnosuke TSUJI
  • Drug Promoting Ceramide Transport, Base Sequence for Producing the Drug, Method of Measuring Activity of Promoting Ceramide Release and Method of Measuring Activity of Promoting Intermembrane Ceramide Transfer
    Publication number: 20080085859
    Abstract: A drug for promoting ceramide transport contains a protein having the amino acid sequence of SEQ ID NO:1 as an effective component; the base sequence of SEQ ID NO:3; a method of measuring an activity for promoting ceramide release comprises mixing a lipid membrane containing ceramide with a drug promoting ceramide release, centrifuging the thus obtained mixture to give a supernatant and measuring the ceramide content in the supernatant; and a method of measuring an activity for promoting intermembrane ceramide transfer comprises mixing a receiving membrane, a drug for promoting ceramide transport and a donating membrane containing ceramide, adding a selective membrane aggregating agent thereto, then separating the receiving membrane from the donating membrane and measuring ceramide contents in the receiving membrane and in the donating membrane.
    Type: Application
    Filed: March 29, 2004
    Publication date: April 10, 2008
    Applicants: JAPAN SCIENCE AND TECHNOLOGY AGENCY, JAPAN AS REP..BY NAT'L INST.OF INFECT. DISEASES
    Inventors: Kentaro Hanada, Masahiro Nishijima, Keigo Kumagai