Patents by Inventor Keiichi Hiramatsu
Keiichi Hiramatsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9809645Abstract: [Problem] The present invention addresses the problem of providing an anti-Staphylococcus antibody having preventive or therapeutic effects on staphylococcal infections. [Solution] Provided is an anti-Staphylococcus antibody having preventive or therapeutic effects on staphylococcal infections and a method for manufacturing said antibody, as well as a composition, a product, and a drug containing said antibody. The antibody is obtained by using deacetylated Staphylococcus for immunization.Type: GrantFiled: March 11, 2014Date of Patent: November 7, 2017Assignees: ZENYAKU KOGYO KABUSHIKIKAISHA, Juntendo Educational FoundationInventors: Hiroyoshi Ohsawa, Jumpei Enami, Keiichi Hiramatsu
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Publication number: 20160257651Abstract: A compound represented by the general formula (I) or a salt thereof having a potent antibacterial activity against bacteria that have acquired resistance to quinolones, and a medicament for prophylactic and/or therapeutic treatment of an infectious disease containing the compound or a salt thereof as an active ingredient, as well as a medicament for prophylactic and/or therapeutic treatment of an infectious disease containing a combination of the compound or a salt thereof, and a quinolone.Type: ApplicationFiled: April 18, 2014Publication date: September 8, 2016Applicant: JUNTENDO EDUCATIONAL FOUNDATIONInventors: Keiichi HIRAMATSU, Yuh MORIMOTO, Tadashi BABA, Isao HAYAKAWA
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Publication number: 20160143878Abstract: An antibacterial agent comprising a compound represented by the following general formula (I), which can exhibit potent antibacterial activity against bacteria that have acquired resistance to quinolones (in the formula, R1 and R4 represents hydrogen atom, hydroxyl group, or a lower alkoxy group; R2 and R3 represents hydrogen atom or hydroxyl group; R5 represents hydrogen atom, a lower cyclic alkyl group, or a lower alkoxy group; R1? and R5? represents hydrogen atom; R2? and R3? represents hydrogen atom, hydroxyl group, or a lower alkoxy group; and R4? represents hydrogen atom or hydroxyl group).Type: ApplicationFiled: February 8, 2016Publication date: May 26, 2016Applicant: JUNTENDO EDUCATIONAL FOUNDATIONInventors: Keiichi HIRAMATSU, Yuh MORIMOTO, Tadashi BABA
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Publication number: 20160024190Abstract: [Problem] The present invention addresses the problem of providing an anti-Staphylococcus antibody having preventive or therapeutic effects on staphylococcal infections. [Solution] Provided is an anti-Staphylococcus antibody having preventive or therapeutic effects on staphylococcal infections and a method for manufacturing said antibody, as well as a composition, a product, and a drug containing said antibody. The antibody is obtained by using deacetylated Staphylococcus for immunization.Type: ApplicationFiled: March 11, 2014Publication date: January 28, 2016Applicants: ZENYAKU KOGYO KABUSHIKIKAISHA, Juntendo Educational FoundationInventors: Hiroyoshi OHSAWA, Jumpei ENAMI, Keiichi HIRAMATSU
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Publication number: 20150322033Abstract: An antibacterial agent comprising a compound represented by the following general formula (I), which can exhibit potent antibacterial activity against bacteria that have acquired resistance to quinolones (in the formula, R1 and R4 represents hydrogen atom, hydroxyl group, or a lower alkoxy group; R2 and R3 represents hydrogen atom or hydroxyl group; W represents hydrogen atom, a lower cyclic alkyl group, or a lower alkoxy group; R1? and R5? represents hydrogen atom; R2? and R3? represents hydrogen atom, hydroxyl group, or a lower alkoxy group; and R4? represents hydrogen atom or hydroxyl group).Type: ApplicationFiled: November 12, 2013Publication date: November 12, 2015Applicant: JUNTENDO EDUCATIONAL FOUNDATIONInventors: Keiichi HIRAMATSU, Yuh MORIMOTO, Tadashi BABA
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Publication number: 20120258980Abstract: A method for treating an individual infected with drug-resistant bacteria resistant to at least one drug, the method including: administering to the individual an antibacterial agent for drug-resistant bacteria which comprises at least one of a nybomycin and a derivative thereof, wherein the antibacterial agent for drug-resistant bacteria is effective to the drug-resistant bacteria resistant to at least one drug.Type: ApplicationFiled: May 9, 2012Publication date: October 11, 2012Inventors: Masayuki Igarashi, Keiichi Hiramatsu
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Patent number: 8217150Abstract: According to the present invention, an antibody against a Panton-Valentine leukocidin toxin contained in Staphylococcus aureus, a method and a kit for detecting the toxin with the use of the antibody, and a pharmaceutical composition containing an antibody against a Panton-Valentine leukocidin toxin for treating PVL infection caused by Staphylococcus aureus containing PVL are provided. Also, an antibody which is capable of binding to Panton-Valentine leukocidin F and has no cross-reactivity to LukD and/or HlgB and an antibody which is capable of binding to Panton-Valentine leukocidin S and has no cross-reactivity to at least one of LukE, HlgC, and HlgA are provided.Type: GrantFiled: May 23, 2011Date of Patent: July 10, 2012Assignees: Juntendo University School of Medicine, Denka Seiken Co., Ltd.Inventors: Kanenari Ohishi, Tadashi Baba, Keiichi Hiramatsu, Yasuo Nakatomi
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Publication number: 20110223614Abstract: According to the present invention, an antibody against a Panton-Valentine leukocidin toxin contained in Staphylococcus aureus, a method and a kit for detecting the toxin with the use of the antibody, and a pharmaceutical composition containing an antibody against a Panton-Valentine leukocidin toxin for treating PVL infection caused by Staphylococcus aureus containing PVL are provided. Also, an antibody which is capable of binding to Panton-Valentine leukocidin F and has no cross-reactivity to LukD and/or HlgB and an antibody which is capable of binding to Panton-Valentine leukocidin S and has no cross-reactivity to at least one of LukE, HlgC, and HlgA are provided.Type: ApplicationFiled: May 23, 2011Publication date: September 15, 2011Inventors: Kanenari OHISHI, Tadashi Baba, Keiichi Hiramatsu, Yasuo Nakatomi
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Patent number: 7947808Abstract: According to the present invention, an antibody against a Panton-Valentine leukocidin toxin contained in Staphylococcus aureus, a method and a kit for detecting the toxin with the use of the antibody, and a pharmaceutical composition containing an antibody against a Panton-Valentine leukocidin toxin for treating PVL infection caused by Staphylococcus aureus containing PVL are provided. Also, an antibody which is capable of binding to Panton-Valentine leukocidin F and has no cross-reactivity to LukD and/or HlgB and an antibody which is capable of binding to Panton-Valentine leukocidin S and has no cross-reactivity to at least one of LukE, HlgC, and HlgA are provided.Type: GrantFiled: July 3, 2007Date of Patent: May 24, 2011Assignee: Juntendo University School of MedicineInventors: Kanenari Ohishi, Tadashi Baba, Keiichi Hiramatsu, Yasuo Nakatomi
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Publication number: 20100092487Abstract: According to the present invention, an antibody against a Panton-Valentine leukocidin toxin contained in Staphylococcus aureus, a method and a kit for detecting the toxin with the use of the antibody, and a pharmaceutical composition containing an antibody against a Panton-Valentine leukocidin toxin for treating PVL infection caused by Staphylococcus aureus containing PVL are provided. Also, an antibody which is capable of binding to Panton-Valentine leukocidin F and has no cross-reactivity to LukD and/or HlgB and an antibody which is capable of binding to Panton-Valentine leukocidin S and has no cross-reactivity to at least one of LukE, HlgC, and HlgA are provided.Type: ApplicationFiled: July 3, 2007Publication date: April 15, 2010Applicants: JUNTENDO UNIVERSITY SCHOOL OF MEDICINE, DENKA SEIKEN CO., LTD.Inventors: Kanenari Ohishi, Tadashi Baba, Keiichi Hiramatsu, Yasuo Nakatomi
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Patent number: 6897304Abstract: A cephem compound or pharmaceutically acceptable salt thereof represented by the formula I: wherein R1 and R2 may be the same or different and each represent hydrogen atom, nitro or cyano; R3 represents C1-C6 alkyl which may be substituted with carboxyl; R4 represents hydrogen atom or amino; X represents —S— or —SO—, there being no case where both of R1 and R2 are simultaneously hydrogen atom.Type: GrantFiled: September 21, 2001Date of Patent: May 24, 2005Assignee: Zenyaku Kogyo Kabushiki KaishaInventors: Seiichiro Kawashima, Keiichi Hiramatsu, Hideaki Hanaki, Hiroaki Yamazaki, Hidenori Harada
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Publication number: 20040019202Abstract: A cephem compound or pharmaceutically acceptable salt thereof represented by the formula I: 1Type: ApplicationFiled: March 21, 2003Publication date: January 29, 2004Inventors: Seiichiro Kawashima, Keiichi Hiramatsu, Hideaki Hanaki, Hiroaki Yamazaki, Hidenori Harada
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Patent number: 6544991Abstract: A composition having antibacterial activity is disclosed. More particularly, a mixture of an oxazolidinone compound, sulbactam, and ampicillin active agents, demonstrating activity against resistant strains of bacteria is disclosed. Methods for using an oxazolidinone compound, sulbactam, and ampicillin to treat a bacterial infection are also described.Type: GrantFiled: June 21, 2001Date of Patent: April 8, 2003Assignee: Pharmacia & Upjohn CompanyInventors: Donald H. Batts, Keiichi Hiramatsu
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Publication number: 20020022610Abstract: A composition having antibacterial activity is disclosed. More particularly, a mixture of an oxazolidinone compound, sulbactam, and ampicillin active agents, demonstrating activity against resistant strains of bacteria is disclosed. Methods for using an oxazolidinone compound, sulbactam, and ampicillin to treat a bacterial infection are also described.Type: ApplicationFiled: June 21, 2001Publication date: February 21, 2002Inventors: Donald H. Batts, Keiichi Hiramatsu
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Patent number: 6294527Abstract: An antibacterial compound wherein represents benzene ring, pyridine ring, pyrazine ring or 5-membered aromatic neterocycle (having one oxygen or sulfur atom as ring-constituting atom), there being no R4 where represents 5-membered aromatic heterocycle; X and Y respectively represent hydrogen atom or CXY represents C═N—OR5 wherein R5 represents hydrogen atom, halo C1-C6 alkyl or C3-C7 cycloalkyl; R1 represents phenyl, furyl, thienyl, thiazolyl (which may be substituted by amino group), tetrazolyl or thiadiazolyl, R2, R3 and R4 respectively represent hydrogen atom, halogen, hydroxyl group, nitro, C1-C6 alkoxy, trifluoromethyl, isothiuronium C1-C6 alkyl, amino C1-C6 alkyl, halo C1-C6 alkyl, morpholino, piperidino or piperazinyl.Type: GrantFiled: July 20, 1999Date of Patent: September 25, 2001Assignee: Zenyaku Kogyo Kabushiki KaishaInventors: Hideaki Hanaki, Hiroaki Yamazaki, Yoshio Tsuchida, Hideki Sato, Keiichi Hiramatsu, Seiichiro Kawashima
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Patent number: 6156507Abstract: Disclosed is a specific identification method of an MRSA and MRC-NS, which is speedy, simple and reliable. Specifically, the present invention provides a diagnostic method of an MRSA or MRC-NS, which comprises performing a reaction with a sample by making combined use of a part of a mecDNA, which is an integrated adventitious DNA existing on a chromosome of the MRSA or MRC-NS and carrying an mecA gene thereon, and a part of a nucleotide sequence of a chromosomal DNA surrounding the integrated DNA; and also a diagnostic method of an MRSA or MRC-NS by PCR, LCR or hybridization, which comprises performing a reaction with a sample by using a nucleotide sequence of a chromosomal DNA surrounding an integrated site of a mecDNA in a chromosome of an MSSA or MSC-NS, wherein said method makes use of an occurrence of a negative reaction when said sample contains a mecDNA integrated therein.Type: GrantFiled: October 23, 1997Date of Patent: December 5, 2000Assignee: Kainos Laboratories, Inc.Inventors: Keiichi Hiramatsu, Teruyo Ito, Akira Awaya, Hiroie Ohno, Tsukasa Hayashi