Abstract: An iontophoretic interface comprising a non-electroconductive material of a porous or capillary structure, coated and treated with a disinfecting and preserving ionic surfactant on the portion of the surface coming into contact with the drug as well as a skin pre-treatment composition and a skin pre-treatment method.

Abstract: An interface is formed by incorporating (1) a mixture comprising a water-soluble protein and a drug into a matrix, or preferably (2) a mixture comprising a water-soluble protein and a drug to a porous matrix coated with a cationic surfactant or other ionic surfactant. The coating amount of the ionic surfactant is about 0.1 to 50 .mu.g, and the content of the water-soluble protein is about 0.1 to 1,500 .mu.g, each per 1 cm.sup.2 of the matrix. The water-soluble protein includes an albumin and the drug includes a physiologically active peptide or protein, for example. The use of the stabilized interface inhibits decrease of the drug retaining amount, and insures an effective transdermal drug delivery with a high repeatability and accuracy.

Abstract: An electrode system for administration of a pharmaceutical by iontophoresis which is comprised of an electroconductive substrate and a functional polymer having ammonium hydroxide or a quaternary ammonium halogen salt, sulfonic group, carboxylic group, amine group.

Abstract: A calcitonin, its derivative or a salt thereof is transdermally delivered by iontophoresis in which a substantially constant voltage in the range of 3 to 20 V is applied at an electric current of 0.05 to 0.5 mA/cm.sup.2. In this process, the calcitonin can be delivered transdermally with a higher absorptivity by applying a higher voltage for a short period (at a voltage of about 6 to 14 V for about 5 to 15 minutes) in the initial stage of the voltage application, and then applying a lower voltage for a long period (at a voltage of about 3 to 9 V for about 30 to 40 minutes).

Abstract: A cosmetic composition containing triglyceride oleate and yeast extract and further, if desired, an L-cysteine hydrochloride as components for proliferating indigenous bacteria on the skin.

Abstract: An interface composed of an aqueous solution supply portion capable of providing a fine hole for supplying an aqueous solution, a water-permeable electrode, and a water-absorbable or water-permeable film-like membrane, laminated integrally, wherein the fine hole for supplying the solution is made in the aqueous solution supply portion at the time of use, the aqueous solution is supplied through the water-permeable electrode and water-absorbable or water-permeable film-like membrane, and, when the aqueous solution reaches them, the drug or the drug-containing water-soluble layer dissolve and a locally high concentration solution of the drug is formed.

Abstract: To avoid a reduction of the conductivity in iontophoresis due to the electrical decomposition and the changes in chemical properties of the electrodes themselves, covering by an electrical insulator, and to prevent a drop in the transport rate due to ions freed from the electrode. Provision is made of an electrode structure provided integrally with a reversible electrode and an auxiliary electrode for regeneration of the same and a regeneration current conducting means for conducting a current for regeneration of the reversible electrode when the therapeutic current is off, or the invention is comprised of a reversible electrode and an ion exchange membrane difficult for ions freed from that electrode to penetrate.

Abstract: A printed electrode for biological use comprises a support having thereon a printed ink paste or binder containing (a) a microgranule of at least one hydrophilic substance selected from the group consisting of hydrophilic polymers and water-soluble substances and (b) a microgranule of an electroconductive substance.