Abstract: A compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer having resistance to anti-PD-1 antibody/anti-PD-L1 antibody therapy is provided. The present inventors have conducted studies on a compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer having resistance to anti-PD-1 antibody/anti-PD-L1 antibody therapy, and found that a pyridazinyl-thiazolecarboxamide compound has DGK ? (DGKzeta) inhibitory effect, leading to completion of the present invention. The pyridazinyl-thiazolecarboxamide compound of the present invention has DGK ? inhibitory effect, and can be used as a therapeutic agent for treatment of cancer related to activation of immune cells or cancer having resistance to anti-PD-1 antibody/anti-PD-L1 antibody therapy.

Abstract: A compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy is provided. The present inventors have conducted studies on a compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy, and confirmed that a heteroaryl carboxamide compound has DGK ? (DGKzeta) inhibitory effect, leading to completion of the present invention. The heteroaryl carboxamide compound of the present invention has DGK ? inhibitory effect, and can be used as a therapeutic agent for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy.

Abstract: A compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy is provided. The present inventors have conducted studies on a compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy, and confirmed that a heteroaryl carboxamide compound has DGK ? (DGKzeta) inhibitory effect, leading to completion of the present invention. The heteroaryl carboxamide compound of the present invention has DGK ? inhibitory effect, and can be used as a therapeutic agent for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy.

Abstract: A compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy is provided. The present inventors have conducted studies on a compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy, and confirmed that a heteroaryl carboxamide compound has DGK ? (DGKzeta) inhibitory effect, leading to completion of the present invention. The heteroaryl carboxamide compound of the present invention has DGK ? inhibitory effect, and can be used as a therapeutic agent for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy.

Abstract: A compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer having resistance to anti-PD-1 antibody/anti-PD-L1 antibody therapy is provided. The present inventors have conducted studies on a compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer having resistance to anti-PD-1 antibody/anti-PD-L1 antibody therapy, and found that a pyridazinyl-thiazolecarboxamide compound has DGK ? (DGKzeta) inhibitory effect, leading to completion of the present invention. The pyridazinyl-thiazolecarboxamide compound of the present invention has DGK ? inhibitory effect, and can be used as a therapeutic agent for treatment of cancer related to activation of immune cells or cancer having resistance to anti-PD-1 antibody/anti-PD-L1 antibody therapy.

Abstract: An automobile door latch device includes: a mesh mechanism; a body; a base; and an operation mechanism disposed on the base, the operation mechanism including: an outside lever configured to receive an operating force of an outside handle to perform open actuation; a first open lever configured to perform open actuation in conjunction with open actuation of the outside lever; a locking/unlocking mechanism; a second open lever configured to perform open actuation in conjunction with open actuation of the first open lever output from the locking/unlocking mechanism; and a fully open release lever configured to perform open actuation in conjunction with open actuation of the first open lever, wherein the fully open release lever is connected to an operating force transmission member configured to transmit the open actuation of the fully open release lever to a fully opening latch device for holding the slide door in a fully open position.

Abstract: An automobile door latch device includes: a mesh mechanism; a body; a base; and an operation mechanism disposed on the base, the operation mechanism including: an outside lever configured to receive an operating force of an outside handle to perform open actuation; a first open lever configured to perform open actuation in conjunction with open actuation of the outside lever; a locking/unlocking mechanism; a second open lever configured to perform open actuation in conjunction with open actuation of the first open lever output from the locking/unlocking mechanism; and a fully open release lever configured to perform open actuation in conjunction with open actuation of the first open lever, wherein the fully open release lever is connected to an operating force transmission member configured to transmit the open actuation of the fully open release lever to a fully opening latch device for holding the slide door in a fully open position.

Abstract: A vehicle body rear part structure includes a bumper beam, an extension, and a gusset. The bumper beam extends in a vehicle width direction in a rear part of a vehicle body. The extension is provided for attaching the bumper beam to the vehicle body. The gusset is provided between the bumper beam and the extension and at an inner position in a vehicle width direction of the extension. A deformation facilitating part is provided on a middle part of the gusset.

Abstract: A vehicle body rear portion structure includes a rear end panel, a rear side frame, a rear end cross member, a first gusset, and a second gusset. The rear end cross member extends in a vehicle width direction along the rear end panel and is separately disposed above the rear side frame. The first gusset connects the rear side frame to the rear end panel. The second gusset connects the rear side frame to the rear end cross member above the first gusset.

Abstract: An upper side joint section that extends inward in a vehicle width direction from a vicinity of a rear side frame and a lateral side joint section that extends downward from the upper side joint section and that is separated in the vehicle width direction from the rear side frame are provided on a rear floor panel of a vehicle body rear part structure. The rear panel has: a frame joint part to which the rear side frame is joined; a first floor joint part to which the upper side joint section of the rear floor panel is joined; and a second floor joint part to which the lateral side joint section of the rear floor panel is joined. A longitudinal bead is provided on a part of the rear panel between the frame joint part and the second floor joint part. The longitudinal bead extends to a lower end of the rear panel and is opened downward.

Abstract: A vehicle body rear part structure includes a bumper beam, an extension, and a gusset. The bumper beam extends in a vehicle width direction in a rear part of a vehicle body. The extension is provided for attaching the bumper beam to the vehicle body. The gusset is provided between the bumper beam and the extension and at an inner position in a vehicle width direction of the extension. A deformation facilitating part is provided on a middle part of the gusset.

Abstract: An upper side joint section that extends inward in a vehicle width direction from a vicinity of a rear side frame and a lateral side joint section that extends downward from the upper side joint section and that is separated in the vehicle width direction from the rear side frame are provided on a rear floor panel of a vehicle body rear part structure. The rear panel has: a frame joint part to which the rear side frame is joined; a first floor joint part to which the upper side joint section of the rear floor panel is joined; and a second floor joint part to which the lateral side joint section of the rear floor panel is joined. A longitudinal bead is provided on a part of the rear panel between the frame joint part and the second floor joint part. The longitudinal bead extends to a lower end of the rear panel and is opened downward.

Abstract: A vehicle body rear portion structure includes a rear end panel, a rear side frame, a rear end cross member, a first gusset, and a second gusset. The rear end cross member extends in a vehicle width direction along the rear end panel and is separately disposed above the rear side frame. The first gusset connects the rear side frame to the rear end panel. The second gusset connects the rear side frame to the rear end cross member above the first gusset.

Abstract: An electric step control device for a vehicle having a step provided movably by power of a motor from a retraction position where the step is retracted under a vehicle body to an overhang position where the step appears from the vehicle body or vice versa according to an opening and closure operation of a door, has a control unit. The control unit executes an overhang drive control that moves the step from the retraction position to the overhang position according to an occurrence of the opening operation of the door having been at a closure position. And the control unit starts a retraction drive control that moves the step from the overhang position to the retraction position according to an occurrence of the closure operation of the door having been at a full open position at a predetermined timing before the door reaches the closure position.

Abstract: An electric step control device for a vehicle having a step provided movably by power of a motor from a retraction position where the step is retracted under a vehicle body to an overhang position where the step appears from the vehicle body or vice versa according to an opening and closure operation of a door, has a control unit. The control unit executes an overhang drive control that moves the step from the retraction position to the overhang position according to an occurrence of the opening operation of the door having been at a closure position. And the control unit starts a retraction drive control that moves the step from the overhang position to the retraction position according to an occurrence of the closure operation of the door having been at a full open position at a predetermined timing before the door reaches the closure position.

Abstract: An IPU protection guard includes a pair of left and right upper horizontal members, which extend along a forward and rearward direction on an upper portion of an IPU on both sides in a vehicle width direction of the IPU, a pair of left and right lower horizontal members, which extend along the forward and rearward direction on a lower portion of the IPU on both sides in the vehicle width direction of the IPU, and an X-shaped member which extends in an X shape along a rear surface of the IPU.

Abstract: A driving apparatus for a sliding member includes a housing, a cable, a drum to move the cable to open and close the sliding member, a motor arranged to drive the drum, and a tensioner supported by the housing arranged to provide a tensioning force to the cable, the tensioner is arranged: to be switched from a first state where an urging force of a spring is stored to a second state where the urging force of the spring is released, to be moved from a first position where the tensioner does not provide the tensioning force to the cable to a second position where the tensioner provides an initial tensioning force to the cable when the tensioner is in the first state, and to be fixed in the second position and to be switched to the second state to provide the tensioning force to the cable by the urging force of the spring.

Abstract: A powered step device of a vehicle comprises a base member that is adapted to be connected to a vehicle body; a pivoting mechanism held by the base member, the pivoting mechanism being horizontally movable between a first position wherein a given part thereof takes a retracted position relative to the base member and a second position wherein the given part takes a projected position relative to the base member; a step plate connected to the given part of the pivoting mechanism, so that the first and second positions of the pivoting mechanism induce retracted and projected positions of the step plate relative to the base member; and an electric actuator that moves the pivoting mechanism with electric power. The powered step device further comprises a guard member that is fixed to the base member in a manner to cover and protect the pivoting mechanism.

Abstract: A sliding drive apparatus includes: a housing; a cable; a drum arranged to wind the cable to open and close the driven member; a motor arranged to drive the drum; a tensioner supported by the housing, and arranged to provide a tensioning force to the cable,to be switched from a first state that an urging force of a spring is stored, and to a second state that the urging force of the spring is released, to be moved between a first position that the tensioner does not provide the tensioning force to the cable, and a second position that the tensioner provides the initial tensioning force is provided to the cable when the tensioner is in the first state, and to be switched to the second state by fixing in the second position, and to provide the tensioning force to the cable by the urging force of the spring.

Abstract: A powered step device of a vehicle comprises a base member that is adapted to be connected to a vehicle body; a pivoting mechanism held by the base member, the pivoting mechanism being horizontally movable between a first position wherein a given part thereof takes a retracted position relative to the base member and a second position wherein the given part takes a projected position relative to the base member; a step plate connected to the given part of the pivoting mechanism, so that the first and second positions of the pivoting mechanism induce retracted and projected positions of the step plate relative to the base member; and an electric actuator that moves the pivoting mechanism with an electric power. The powered step device further comprises a guard member that is fixed to the base member in a manner to cover and protect the pivoting mechanism.