Abstract: This is to provide a composition for delivering a nucleic acid and a nucleic acid-containing composition which ensure stability of a nucleic acid drug, have a high intracellular introduction rate, can efficiently express the function of a nucleic acid drug, and have low cytotoxicity. Disclosed is a composition for delivering a nucleic acid and a nucleic acid-containing composition each comprises a block copolymer in which a polyethylene glycol segment and a hydrophobic polyester segment are linked, and a peptide having 4 to 30 residues containing at least one selected from the group consisting of arginine and lysine.

Abstract: The present invention aims to provide a novel compound capable of promoting cell proliferation in a cell culture (particularly three-dimensional cell culture). The hydrazide compound represented by the formula (I); wherein each symbol is as defined in DESCRIPTION, or a salt thereof, and a composition containing same can remarkably promote cell proliferation, sphere formation, cyst formation and/or organoid formation, and can also remarkably inhibit the activities of kinase such as LATS1, LATS2 and the like.

Abstract: The invention provides a container for storing a biomaterial in which adhesion of a minute amount of a biomarker(s) contained in the biomaterial to the surface of the container for storage can be suppressed, and sample loss is reduced, while enabling analysis with accuracy and highly precision. In particular, the container for storing a biomaterial for reducing sample loss of a biomarker(s) contained in the biomaterial has a coating containing a copolymer which contains a recurring unit which contains a group represented by the following formula (a), a recurring unit which contains a group represented by the following formula (b), and optionally a recurring unit which contains a group represented by the following formula (c), on at least a part of the surface of the container: (wherein, Ua1, Ua2, Ub1, Ub2 and Ub3, An? and Rc are as defined herein).

Abstract: A cell culture system for dividing and subculturing cell aggregates is constituted by connecting a first container 10 and a divider 20. An outlet of a divider is connected to the first container. A mesh structure 22 for dividing a cell aggregate is provided in a conduit for dividing in the divider 20, and a cell aggregate is divided while passing through the mesh structure. The divided cell aggregate is sent to the first container 10 without contacting the outside air in a preferred embodiment, where further culture is performed. This makes it possible to divide the cell aggregate and perform suspension culture while maintaining the closed system. The division and suspension culture of cell aggregates can be repeated by sending the cultured cell aggregates to a divider of its own cell culture system or a divider of a cell culture system prepared separately.

Abstract: The device has a film-shaped main body part 1, and predetermined region in the film surface of the main body part has a mesh structure in which a large number of through-holes 20 are arranged. The through-hole has an opening shape having a size allowing smaller cell aggregates to pass through, and the rest of the through-hole is the beam part 30. The beam part is a part that cuts a cell aggregate to be divided, and is integrally connected to form a network. The cell aggregate can be divided by passing the cell aggregate to be divided through the mesh structure of the device together with the liquid.

Abstract: The present invention aims to provide a novel kinase inhibitor and the like, and a therapeutic agent for a disease, a drug discovery screening method and the like utilizing such inhibitor and the like. The compound represented by the following formula (I) and a salt thereof can inhibit plural kinases including LATS (particularly LATS2) which is the major kinase in the Hippo signal transduction pathway. In addition, diseases or tissue damage associated with failure of cellular proliferation can be treated. Therefore, the present invention is beneficial, for example, in the research field of cell functions and diseases, in which the Hippo signal transduction pathway is involved, and the like. Furthermore, it is beneficial in the medical field for the treatment of such diseases and the like. wherein each symbol is as defined in the DESCRIPTION.

Abstract: This is to provide a composition for delivering a nucleic acid and a nucleic acid-containing composition which ensure stability of a nucleic acid drug, have a high intracellular introduction rate, can efficiently express the function of a nucleic acid drug, and have low cytotoxicity. Disclosed is a composition for delivering a nucleic acid and a nucleic acid-containing composition each comprises a block copolymer in which a polyethylene glycol segment and a hydrophobic polyester segment are linked, and a peptide having 4 to 30 residues containing at least one selected from the group consisting of arginine and lysine.

Abstract: The present invention provides a medium additive composition containing a compound represented by the following formula (I), or a salt thereof: {wherein each symbol is as defined in the DESCRIPTION.

Abstract: A communication restriction is performed in an appropriate manner for a mobile station (subscriber) that has roamed out of a communication operator's network where subscriber information is registered into another one. In a roaming system including an HLR 110 and a GGSN 120 of a first communication operator's communication network 100 and an SGSN 220 of a second communication operator's communication network 200, the SGSN 220 receives a packet transmission request from a mobile station 210 and transfers it to the GGSN 120. The GGSN 120 that has received the transferred packet transmission request makes an inquiry about subscriber information of the mobile station 210 to the HLR 110. The HLR 110 identifies whether or not the packet transmission request is to be subject to a restriction, and returns an identification result to the GGSN 120 when it is to be subject to the restriction. The GGSN 120 transfers a response to the identification result to the SGSN 220.