Abstract: Provided is a polymeric micelle type DDS preparation that may efficiently exhibit pharmacological activity effects by enhancing migration characteristics, penetrability, and retention characteristics toward a diseased target tissue such as a tumor tissue or an inflammation-affected tissue, and thereby enhancing the action of a pharmacologically active substance. Disclosed is a block copolymer (A) having a hydrophilic polymer segment linked to a hydrophobic polymer segment, the hydrophilic polymer segment containing a polyethylene glycol chain, and the hydrophobic polymer segment containing a polyamino acid chain having a hydrophobic substituent in a side chain, wherein the hydrophilic polymer segment has a target binding site bonded thereto, and the main chain polymer combining the polyethylene glycol chain and the polyamino acid chain has a molecular weight of not less than 2 kilodaltons and not more than 10 kilodaltons.

Abstract: An object of the invention is to obtain a preparation which shows enhanced effectiveness and safety compared to tacrolimus, has the concentration in blood maintained at a constant level without individual differences, whereby the control of the amount of administration depending on the blood kinetics (blood trough concentration) becomes unnecessary. The present invention relates to a polymeric derivative of tacrolimus, in which a polyethylene glycol segment and an alcoholic hydroxy group of tacrolimus are bonded to side-chain carboxy groups of a polyaspartic acid derivative.

Abstract: Provided are a block copolymer having an enhanced effect of imaging the interior of a tumor compared to known block copolymers and imaging probes using the known block copolymers; and an imaging probe using the block copolymer.

Abstract: Provided are a block copolymer having an enhanced effect of imaging the interior of a tumor compared to known block copolymers and imaging probes using the known block copolymers; and an imaging probe using the block copolymer.

Abstract: An object of the invention is to obtain a preparation which shows enhanced effectiveness and safety compared to tacrolimus, has the concentration in blood maintained at a constant level without individual differences, whereby the control of the amount of administration depending on the blood kinetics (blood trough concentration) becomes unnecessary. The present invention relates to a polymeric derivative of tacrolimus, in which a polyethylene glycol segment and an alcoholic hydroxy group of tacrolimus are bonded to side-chain carboxy groups of a polyaspartic acid derivative.

Abstract: A switching device for a vehicle headlight of a vehicle having an Adaptive LED Headlight (ALH) mode. The switching device may include a steering column lever switch supported on a steering column of the vehicle so as to be movable between an initial position and a predetermined moved position by a moving operation input, an ALH switch configured to receive a switching operation input that sets the ALH mode, and a controller configured to change the irradiation mode of the headlight according to a position of the lever switch and the switching operation input received by the ALH switch.

Abstract: Provided are a block copolymer having an enhanced effect of imaging the interior of a tumor compared to known block copolymers and imaging probes using the known block copolymers; and an imaging probe using the block copolymer.

Abstract: A switching device for a vehicle headlight of a vehicle having an Adaptive LED Headlight (ALH) mode. The switching device may include a steering column lever switch supported on a steering column of the vehicle so as to be movable between an initial position and a predetermined moved position by a moving operation input, an ALH switch configured to receive a switching operation input that sets the ALH mode, and a controller configured to change the irradiation mode of the headlight according to a position of the lever switch and the switching operation input received by the ALH switch.

Abstract: Provided is a polymeric micelle type DDS preparation that may efficiently exhibit pharmacological activity effects by enhancing migration characteristics, penetrability, and retention characteristics toward a diseased target tissue such as a tumor tissue or an inflammation-affected tissue, and thereby enhancing the action of a pharmacologically active substance. Disclosed is a block copolymer (A) having a hydrophilic polymer segment linked to a hydrophobic polymer segment, the hydrophilic polymer segment containing a polyethylene glycol chain, and the hydrophobic polymer segment containing a polyamino acid chain having a hydrophobic substituent in a side chain, wherein the hydrophilic polymer segment has a target binding site bonded thereto, and the main chain polymer combining the polyethylene glycol chain and the polyamino acid chain has a molecular weight of not less than 2 kilodaltons and not more than 10 kilodaltons.

Abstract: A physiologically active substance-conjugated block copolymer having enhanced efficacy and/or safety is provided by enhancing the property of penetrating into a target diseased tissue and/or enhancing excretability, compared to known physiologically active substance-conjugated block copolymer, and suppressing sensitization of the physiologically active substance to normal tissues other than a target diseased tissue. Disclosed is a block copolymer including a polyethylene glycol segment connected with a polyamino acid derivative segment conjugated with a physiologically active substance, in which the molecular weight of the block copolymer is from 2 kilodaltons to 15 kilodaltons, and the light scattering intensity of a 1 mg/mL aqueous solution of the physiologically active substance-conjugated block copolymer as measured with a laser light scattering photometer is at least twice or more the light scattering intensity of toluene.

Abstract: A human body model is disclosed that can make an image acquired by a medical device similar to an image of a body lumen acquired during surgery. The human body model includes a main body portion that includes a lumen passing through a portion of the main body portion between a first surface and a second surface disposed on a side opposite to the first surface, and a tubular body that is provided in at least a part of the lumen and is made of another material different from the material of the main body portion. An acoustic impedance of the material of the tubular body being equal to an acoustic impedance of a body lumen, and a hardness of the material of the main body portion being higher than a hardness of the material of the tubular body.

Abstract: A problem of the present invention is to obtain a preparation which shows markedly enhanced effectiveness and safety by exhibiting high accumulability at diseased areas and having the blood concentration maintained at a constant level without individual differences, and for which the control of the dosage depending on the blood kinetics (blood trough concentration) becomes unnecessary. The invention relates to a polymeric derivative of tacrolimus including a copolymer of a polyethylene glycol segment and a polymeric moiety, in which a carboxy group in a side chain of the copolymer is bonded to an alcoholic hydroxy group of tacrolimus.

Abstract: A physiologically active substance-conjugated block copolymer having enhanced efficacy and/or safety is provided by enhancing the property of penetrating into a target diseased tissue and/or enhancing excretability, compared to known physiologically active substance-conjugated block copolymer, and suppressing sensitization of the physiologically active substance to normal tissues other than a target diseased tissue. Disclosed is a block copolymer including a polyethylene glycol segment connected with a polyamino acid derivative segment conjugated with a physiologically active substance, in which the molecular weight of the block copolymer is from 2 kilodaltons to 15 kilodaltons, and the light scattering intensity of a 1 mg/mL aqueous solution of the physiologically active substance-conjugated block copolymer as measured with a laser light scattering photometer is at least twice or more the light scattering intensity of toluene.

Abstract: A switch device includes a push switch including first and second push portions that are parallel arranged, and an operating switch arranged between the first and second push portions and including a switch operation direction different from a switch operation direction of the first and second push portions. The operating switch protrudes from an operation surface of the first and second push portions so as to allow the first and second push portions to be individually recognized when operating the push switch.

Abstract: A switch device includes a push switch including first and second push portions that are parallel arranged, and an operating switch arranged between the first and second push portions and including a switch operation direction different from a switch operation direction of the first and second push portions. The operating switch protrudes from an operation surface of the first and second push portions so as to allow the first and second push portions to be individually recognized when operating the push switch.

Abstract: Provided is a high-molecular weight conjugate of resorcinol derivatives which is excellent in water solubility and stability and has high antitumor activity even when used in a smaller total drug amount than the resorcinol derivatives. The high-molecular weight conjugate of resorcinol derivatives comprises a structure in which a carboxyl group of polymer moiety having a carboxyl group in the side chain and polyethylene glycol moiety is linked to a hydroxyl group of resorcinol derivatives via an ester bond.

Abstract: A dial switch is operative to be rotated or tilted and to be pushed down, which can select any one of icons displayed on a menu screen of a display portion and display information regarding a function of an onboard apparatuses corresponding to a selected icon on the display portion. A central pushing switch is configured to function as a home key such that a default-state menu screen is displayed on the display portion whenever this switch is pushed down. Left or right pushing switches is configured to function as a shortcut key such that information regarding a function of an onboard apparatus corresponding to left-positioned or right-positioned icons positioned on left and right sides of a central icon is displayed on the display portion whenever the left or right pushing switches is pushed down.

Abstract: Providing a method for producing a compound represented by formula (1) from a compound represented by formula (2), by which the additive amount of an aryl (C1-C8) alkyl alcohol which may have a substituent and the amount of residual carboxyl groups of pAsp (polyaspartic acid) are controlled. A production method including obtaining a compound represented by formula (1) by allowing a compound represented by formula (2) to react with an aryl (C1-C8) alkyl alcohol which may have a substituent, and a carbodiimide-based compound in an amount of 2(x+y) equivalents or more relative to the amount of carboxyl groups in formula (2) (sum of x and y), in a solvent at 15° C. to 30° C. for 2 hours to 48 hours, is used.

Abstract: A switch body portion attached to a center console includes a dial switch. The switch body portion is held on the side of the enter console for attachment through engaging of front engagement portions and a rear engagement portion. When an external force having a specified magnitude or greater acts on the dial switch from the rear, the engaging of the front engagement portions is released, so that the switch body portion falls off downward, rotating around the rear engagement portion. Accordingly, an impact which may occur when some object hits against the dial switch projecting upward from an upper face of the center console from the rear can be properly absorbed.

Abstract: [Problem]To provide a novel polymer derivative of a cytidine metabolic antagonist which allows release of a medicament irrespective of enzymes of the living body and is expected to have high therapeutic effects.