Patents by Inventor Keiji Endo
Keiji Endo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7981659Abstract: Novel Bacillus subtilis mutant strains having good productivity of various enzymes are provided through extensive analysis of strains that are derived from Bacillus subtilis via gene disruption. The Bacillus subtilis mutant strains according to the present invention have genomic structures prepared by deletion of regions listed in the columns for deficient regions. Each of these Bacillus subtilis mutant strains exerts significantly improved secretory productivity of a protein when a gene encoding such a secretory target protein is introduced so that it can be expressed, compared with a case in which the same gene is introduced into a wild-type strain.Type: GrantFiled: September 25, 2006Date of Patent: July 19, 2011Assignees: Kao Corporation, Nara Institute of Science and TechnologyInventors: Ryosuke Kadoya, Keiji Endo, Masatoshi Tohata, Katsutoshi Ara, Naotake Ogasawara
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Publication number: 20110151567Abstract: A recombinant microorganism having improved productivity for a protein or a polypeptide, and a method for producing a protein or a polypeptide using the recombinant microorganism, are provided. A recombinant microorganism obtained by transfecting a gene for encoding a desired protein or polypeptide into a microorganism strain which is obtained by genetically constructing to overexpress secY gene of Bacillus subtilis or a gene corresponding to the secY gene, and deleting or inactivating one or more genes selected from sporulation-associated genes and genes corresponding to the sporulation-associated genes from the genome.Type: ApplicationFiled: April 8, 2008Publication date: June 23, 2011Applicant: KAO CORPORATIONInventors: Shenghao Liu, Keiji Endo, Katsutoshi Ara
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Publication number: 20110059847Abstract: A herbicide composition for paddy field characterized by containing (a) a herbicidal difluoromethanesulfonamide derivative represented by the formula (I) and (b) at least one herbicidal compound selected from the group consisting of pretilachlor, butachlor, alachlor, metolachlor, acetochlor, clomeprop, bromobutide, benfuresate, indanofan, pyrazolate, benzofenap, pyrazoxyfen, pyraclonil, oxaziclomefone, bensulfuron-methyl, azimsulfuron, imazosulfuron, pyrazosulfuron-ethyl, cyclosulfamuron, ethoxysulfuron, halosulfuron-methyl, orthosulfamuron, cinosulfuron, metsulfuron-methyl, penoxsulam, thiobencarb, pyributycarb, molinate, dimethametryn, simetryn, cafenstrole, quinclorac, anilofos, mefenacet, fentrazamide, pentoxazone, oxadiargyl, oxadiazon, benzobicyclon, mesotrione, AVH301 (code no.Type: ApplicationFiled: November 10, 2010Publication date: March 10, 2011Applicant: Bayer CropScience AGInventors: Keiji Endo, Shinichi Shirakura, Shin Nakamura, Natsuko Minegishi
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Publication number: 20100323896Abstract: Herbicidal compositions comprising containing sulfonanilides of the formula (I) wherein R1 represents hydrogen, fluorine, chlorine, C1-4 alkyl, C1-4 alkoxy, C3-6 cycloalkyl-C1-4 alkyloxy or C1-4 haloalkoxy, R2 represents hydrogen, fluorine or chlorine, R3 represents hydrogen or fluorine, R4 represents hydrogen or C1-4 alkyl which may be optionally C1-4 alkoxy-substituted, C3-6 alkenyl or C3-6 alkynyl, R5 represents hydrogen, R6 represents hydroxy, fluorine or chlorine, or R5 and R6 may form, together with the carbon to which they are bonded, C?O, and X represents CH or N, provided that the following cases are excluded: (i) R1 represents hydrogen, fluorine or chlorine, R2 represents hydrogen, R3 represents hydrogen, R4 represents hydrogen, R5 represents hydrogen, and R6 represents hydroxy, (ii) R1 represents hydrogen, fluorine or chlorine, R2 represents hydrogen, R3 represents hydrogen, R4 represents hydrogen, and R5 and R6 form C?O together with the carbon to which they are bonded, (iii) R1 represents C1-Type: ApplicationFiled: August 25, 2010Publication date: December 23, 2010Applicant: Bayer CropScience AGInventors: Koichi Araki, Yoshitaka Sato, Takuya Gomibuchi, Keiji Endo, Shinichi Shirakura, Shin Nakamura, Christopher Rosinger, Dieter Feucht
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Patent number: 7855165Abstract: A herbicide composition for paddy field characterized by containing (a) a herbicidal difluoromethanesulfonamide derivative represented by the formula (I) and (b) at least one herbicidal compound selected from the group consisting of pretilachlor, butachlor, alachlor, metolachlor, acetochlor, clomeprop, bromobutide, benfuresate, indanofan, pyrazolate, benzofenap, pyrazoxyfen, pyraclonil, oxaziclomefone, bensulfuron-methyl, azimsulfuron, imazosulfuron, pyrazosulfuron-ethyl, cyclosulfamuron, ethoxysulfuron, halosulfuron-methyl, orthosulfamuron, cinosulfuron, metsulfuron-methyl, penoxsulam, thiobencarb, pyributycarb, molinate, dimethametryn, simetryn, cafenstrole, quinclorac, anilofos, mefenacet, fentrazamide, pentoxazone, oxadiargyl, oxadiazon, benzobicyclon, mesotrione, AVH301 (code no.Type: GrantFiled: January 12, 2007Date of Patent: December 21, 2010Assignee: Bayer Cropscience AGInventors: Keiji Endo, Shinichi Shirakura, Shin Nakamura, Natsuko Minegishi
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Patent number: 7855065Abstract: The present invention provides a mutant Bacillus bacterium capable of enhancing productivity of proteins or polypeptides, a recombinant microorganism produced by introducing genes encoding heterologous proteins or polypeptides into the mutant Bacillus bacterium, and a method for producing proteins or polypeptides by use of the recombinant microorganism. A mutant Bacillus bacterium which has, on the genome or plasmid thereof, DNA having a promoter sequence which is recognized and transcribed specifically during the sporulation stage and which is ligated to an upstream end of a sigA gene or a gene equivalent thereto, a recombinant microorganism produced by introducing genes encoding heterologous proteins or polypeptides into the mutant Bacillus bacterium, and a method for producing proteins or polypeptides by use of the recombinant microorganism.Type: GrantFiled: March 4, 2005Date of Patent: December 21, 2010Assignee: Kao CorporationInventors: Keiji Endo, Katsuya Ozaki
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Patent number: 7829322Abstract: A host microorganism capable of increasing productivity of a protein or polypeptide, a recombinant microorganism obtained by introducing a gene encoding a protein or polypeptide into the host microorganism, and a method for producing a protein or polypeptide using the recombinant microorganism are provided. Also provided is a recombinant microorganism obtained by introducing into a host microorganism a gene encoding a heterologous protein or polypeptide, wherein in said host microorganism the Bacillus subtilis aprX gene or a gene corresponding to the aprX gene has been deleted or knocked out, and a method for producing a protein or polypeptide using the recombinant microorganism.Type: GrantFiled: December 20, 2005Date of Patent: November 9, 2010Assignees: Kao Corporation, Shinshu UniversityInventors: Takeko Kodama, Keiji Endo, Katsuya Ozaki, Junichi Sekiguchi
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Patent number: 7829703Abstract: Novel difluoromethanesulfonamide derivatives of the formula (I) Difluoromethanesulfonamide derivatives represented by the formula wherein X represents halogen, Y represents CH or N, R1 represents hydrogen, and R2 represents hydrogen or hydroxy, or R1 and R2 together may form C?O with the carbon atom to which they are bonded, and their use as herbicide for paddy field weeds.Type: GrantFiled: August 13, 2008Date of Patent: November 9, 2010Assignee: Bayer CropScience AGInventors: Koichi Araki, Sachio Kudo, Yoshitaka Sato, Keiji Endo, Shinichi Shirakura, Shin Nakamura
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Publication number: 20100255534Abstract: Provision of a recombinant microorganism which has increased productivity of a protein or polypeptide of interest and a method for producing a protein or polypeptide of interest using the recombinant microorganism.Type: ApplicationFiled: December 27, 2007Publication date: October 7, 2010Applicant: KAO CORPORATIONInventors: Keiji Endo, Katsutoshi Ara
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Publication number: 20090305894Abstract: Herbicidal compositions comprising containing sulfonanilides of the formula (I), wherein R1 represents hydrogen, fluorine, chlorine, C1-4 alkyl, C1-4 alkoxy, C3-6 cycloalkyl-C1-4 alkyloxy or C1-4 haloalkoxy, R2 represents hydrogen, fluorine or chlorine, R3 represents hydrogen or fluorine, R4 represents hydrogen or C1-4 alkyl which may be optionally C1-4 alkoxy-substituted, C3-6 alkenyl or C3-6 alkynyl, R5 represents hydrogen, R6 represents hydroxy, fluorine or chlorine, or R5 and R6 may form, together with the carbon to which they are bonded, C?O, and X represents CH or N, provided that the following cases are excluded: (i) R1 represents hydrogen, fluorine or chlorine, R2 represents hydrogen, R3 represents hydrogen, R4 represents hydrogen, R5 represents hydrogen, and R6 represents hydroxy, (ii) R1 represents hydrogen, fluorine or chlorine, R2 represents hydrogen, R3 represents hydrogen, R4 represents hydrogen, and R5 and R6 form C?O together with the carbon to which they are bonded, (iii) R1 represents C1-4 aType: ApplicationFiled: September 2, 2006Publication date: December 10, 2009Inventors: Koichi Araki, Yoshitaka Sato, Takuya Gomibuchi, Keiji Endo, Shinichi Shirakura, Shin Nakamura, Christopher Rosinger, Dieter Feucht
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Publication number: 20090226961Abstract: The invention relates to a mutant ?-amylase obtained by making replacement or deletion of at least one of amino acid residues such as the 167th Gln, 169th Tyr and 178th Ala in the amino acid sequence set forth in SEQ ID NO:1 in an ?-amylase having said amino acid sequence, or an ?-amylase having a homology of at least 70% to said amino acid sequence, a gene encoding the mutant ?-amylase, a vector, transformed cells, a process for producing a mutant ?-amylase, comprising culturing the transformed cells, and a detergent composition comprising the mutant ?-amylase. The mutant ?-amylase of the invention has excellent properties of high resistance to chelating agents, high specific activity in an alkaline region and excellent stability to heat, and is hence useful for detergents for automatic dish washer, laundry detergents and the like.Type: ApplicationFiled: September 28, 2007Publication date: September 10, 2009Inventors: Keiji Endo, Kazuaki Igarashi, Yasuhiro Hayashi, Hiroshi Hagihara, Katsuya Ozaki
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Patent number: 7585674Abstract: A microorganism wherein one or more genes selected from the group of genes participating in sporulation in the middle to late stages of sporulation have been deleted or inactivated; and a process for producing a target product (a protein) by use the microorganism. No spore is formed when this microorganism is employed, thereby enabling production of a target product (a protein) while decreasing energy loss, production of a by-product and specific production speed to decrease unnecessary consumption of a medium. Moreover, the production period can be prolonged, whereby the target product (the protein) can be produced efficiently.Type: GrantFiled: May 28, 2002Date of Patent: September 8, 2009Assignee: Kao CorporationInventors: Kazuhisa Sawada, Keiji Endo, Tadahiro Ozawa, Masatoshi Tohata, Katsuya Ozaki
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Publication number: 20090221055Abstract: Novel Bacillus subtilis mutant strains having good productivity of various enzymes are provided through extensive analysis of strains that are derived from Bacillus subtilis via gene disruption. The Bacillus subtilis mutant strains according to the present invention have genomic structures prepared by deletion of regions listed in the columns for deficient regions. Each of these Bacillus subtilis mutant strains exerts significantly improved secretory productivity of a protein when a gene encoding such a secretory target protein is introduced so that it can be expressed, compared with a case in which the same gene is introduced into a wild-type strain.Type: ApplicationFiled: September 25, 2006Publication date: September 3, 2009Inventors: Ryosuke Kadoya, Keiji Endo, Masatoshi Tohata, Katsutoshi Ara, Naotake Ogasawara
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Publication number: 20090170154Abstract: The present invention provides a mutant Bacillus bacterium capable of enhancing productivity of proteins or polypeptides, a recombinant microorganism produced by introducing genes encoding heterologous proteins or polypeptides into the mutant Bacillus bacterium, and a method for producing proteins or polypeptides by use of the recombinant microorganism. A mutant Bacillus bacterium which has, on the genome or plasmid thereof, DNA having a promoter sequence which is recognized and transcribed specifically during the sporulation stage and which is ligated to an upstream end of a sigA gene or a gene equivalent thereto, a recombinant microorganism produced by introducing genes encoding heterologous proteins or polypeptides into the mutant Bacillus bacterium, and a method for producing proteins or polypeptides by use of the recombinant microorganism.Type: ApplicationFiled: March 4, 2005Publication date: July 2, 2009Applicant: KAO CORPORATIONInventors: Keiji Endo, Katsuya Ozaki
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Publication number: 20090081726Abstract: A host microorganism capable of increasing productivity of a protein or polypeptide, a recombinant microorganism obtained by introducing a gene encoding a protein or polypeptide into the host microorganism, and a method for producing a protein or polypeptide using the recombinant microorganism are provided. Also provided is a recombinant microorganism obtained by introducing into a host microorganism a gene encoding a heterologous protein or polypeptide, wherein in said host microorganism the Bacillus subtilis aprX gene or a gene corresponding to the aprX gene has been deleted or knocked out, and a method for producing a protein or polypeptide using the recombinant microorganism.Type: ApplicationFiled: December 20, 2005Publication date: March 26, 2009Inventors: Takeko Kodama, Keiji Endo, Katsuya Ozaki, Junichi Sekiguchi
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Publication number: 20090062536Abstract: A herbicide comprising as an active ingredient a sulfonanilide compound represented by the formula: wherein, R1 represents CHF2 or CH2CF3; R2 represents hydrogen, C1-3 alkyl, 3-propenyl, or 3-propynyl; R3 represents hydrogen; R4 represents hydrogen, hydroxy, or methylthio, or R3 and R4, together with a carbon atom to which they are bonded, may form C?O; R5 represents halogen or methyl; X represents methoxy or chlorine; and Z represents CH or N; with the proviso that, (i) when R1 represents CH2CF3, R2 represents hydrogen, R5 represents bromine or iodine, X represents methoxy, and Z represents CH, (ii) when R1 represents CHF2 and X represents methoxy, R5 represents bromine or iodine, Z represents N, and R2 represents C1-3 alkyl, 3-propenyl, or 3-propynyl, (iii) when R1 represents CHF2 and X represents chlorine, Z represents CH.Type: ApplicationFiled: August 18, 2008Publication date: March 5, 2009Inventors: KOICHI ARAKI, Yoshitaka Sato, Shinichi Shirakura, Keiji Endo, Shin Nakamura, Seiji Ukawa, Chieko Ueno
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Publication number: 20090029417Abstract: The object of the invention is to provide a microorganism which enhances productivity of cellulase and is useful for industrial production of cellulase, and to provide a method for producing cellulase by use of the microorganism. The present invention provides a recombinant microorganism produced by transferring a gene encoding cellulase to a parental microorganism which has been genetically modified so as to overexpress a Bacillus subtilis secY gene or a gene corresponding thereto.Type: ApplicationFiled: February 15, 2007Publication date: January 29, 2009Applicant: Kao CorporationInventors: Keiji Endo, Shenghao Liu, Katsutoshi Ara
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Patent number: 7482308Abstract: Novel difluoromethanesulfonamide derivatives of the formula (I) Difluoromethanesulfonamide derivatives represented by the formula wherein X represents halogen, Y represents CH or N, R1 represents hydrogen, and R2 represents hydrogen or hydroxy, or R1 and R2 together may form C & equals; O with the carbon atom to which they are bonded, and their use as herbicide for paddy field weeds.Type: GrantFiled: March 19, 2005Date of Patent: January 27, 2009Assignee: Bayer CropScience AGInventors: Koichi Araki, Sachio Kudo, Yoshitaka Sato, Keiji Endo, Shinichi Shirakura, Shin Nakamura
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Publication number: 20080312084Abstract: Novel difluoromethanesulfonamide derivatives of the formula (I) Difluoromethanesulfonamide derivatives represented by the formula wherein X represents halogen, Y represents CH or N, R1 represents hydrogen, and R2 represents hydrogen or hydroxy, or R1 and R2 together may form C?O with the carbon atom to which they are bonded, and their use as herbicide for paddy field weeds.Type: ApplicationFiled: August 13, 2008Publication date: December 18, 2008Applicant: BAYER CROPSCIENCE AGInventors: Koichi ARAKI, Sachio KUDO, Yoshitaka SATO, Keiji ENDO, Shinichi SHIRAKURA, Shin NAKAMURA
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Publication number: 20080200337Abstract: Mixed herbicidal compositions for controlling weeds, preferably in paddy field are provided. The compositions are characterized by comprising, as active ingredients, (a) an herbicidal difluoromethane sulfonanilide, (b) at least one herbicidal compound selected from the group consisting of known herbicides as defined in claim 1 and, optionally, (c) one or more compounds selected from the group consisting of safeners.Type: ApplicationFiled: February 15, 2008Publication date: August 21, 2008Applicant: Bayer CropScienceInventors: Keiji Endo, Shinichi Shirakura, Shin Nakamura