Patents by Inventor Keiji Hasumi
Keiji Hasumi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9216987Abstract: The invention provides a chroman derivative represented by the following Formula (I) that enables the production of an SMTP compound having a desired structure: wherein, in Formula (I), each of Y1 and Y2 independently represents a hydrogen atom, a hydroxy group, an alkoxy group, an aryloxy group, or a halogen atom; each of R1 and R2 independently represents a hydrogen atom, an alkyl group, an aryl group, an acyl group, an alkoxycarbonyl group, an aryloxycarbonyl group, or a carbamoyl group; L represents an aliphatic hydrocarbon group having from 4 to 10 carbon atoms; each X independently represents a hydroxy group or a carboxy group; and n represents an integer from 0 to 2.Type: GrantFiled: March 1, 2013Date of Patent: December 22, 2015Assignee: TMS CO., LTD.Inventors: Keiji Hasumi, Eriko Suzuki, Yuuichi Nishimura, Yoshikazu Kitano, Keiko Hasegawa, Naoko Nishimura, Kohta Tsujihara
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Patent number: 9078880Abstract: Disclosed is a cytoprotective agent for use with respect to ischemic damage, including as an active ingredient a triprenyl phenol compound represented by the following general formula (I), wherein X is —CHY—C(CH3)2Z, Y and Z are each independently —H or —OH, or jointly form a single bond, and R represents a hydrogen atom or a substituent with a molecular weight of 1000 or less.Type: GrantFiled: February 5, 2010Date of Patent: July 14, 2015Assignees: National University Corporation Tokyo University of Agriculture and Technology, TMS Co., Ltd., Showa UniversityInventors: Kazuo Honda, Terumasa Hashimoto, Keita Shibata, Keiko Hasegawa, Keiji Hasumi
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Publication number: 20150025251Abstract: The invention provides a chroman derivative represented by the following Formula (I) that enables the production of an SMTP compound having a desired structure: wherein, in Formula (I), each of Y1 and Y2 independently represents a hydrogen atom, a hydroxy group, an alkoxy group, an aryloxy group, or a halogen atom; each of R1 and R2 independently represents a hydrogen atom, an alkyl group, an aryl group, an acyl group, an alkoxycarbonyl group, an aryloxycarbonyl group, or a carbamoyl group; L represents an aliphatic hydrocarbon group having from 4 to 10 carbon atoms; each X independently represents a hydroxy group or a carboxy group; and n represents an integer from 0 to 2.Type: ApplicationFiled: March 1, 2013Publication date: January 22, 2015Applicant: TMS CO., LTD.Inventors: Keiji Hasumi, Eriko Suzuki, Yuuichi Nishimura, Yoshikazu Kitano, Keiko Hasegawa, Naoko Nishimura, Kohta Tsujihara
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Patent number: 8883462Abstract: A triprenyl phenol compound represented by the following formula (II) and (III) and having a thrombolysis-enhancing activity, and an efficient method for producing the triprenyl phenol compound. In formula (II) and (III), R1 represents an aromatic group having as a substituent or as a part of a substituent at least one member selected from the group consisting of a carboxyl group, a hydroxyl group, a sulfonic acid group and a secondary amino group, or an aromatic group which comprises a secondary amino group and may comprise nitrogen; R4 in the general formula (III) represents an aromatic amino acid residue represented by the general formula (III-1) below; X represents —CHY—(CH3)2Z; and Y and Z are respectively —H or —OH or together form a single bond: (III-1) wherein R5 represents a hydroxyl group which may be present or absent; and n represents an integer of 0 or 1.Type: GrantFiled: January 4, 2012Date of Patent: November 11, 2014Assignee: Tokyo University of Agriculture and Technology TLO Co., Ltd.Inventors: Keiji Hasumi, Yoshikazu Kitano, Hideo Ohishi, Haruki Koide, Keiko Hasegawa, Ritsuko Narasaki
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Patent number: 8193173Abstract: The present invention relates to a liver function ameliorant containing orniplabin as an active ingredient thereof.Type: GrantFiled: February 17, 2006Date of Patent: June 5, 2012Assignee: Tokyo University of Agriculture and Technology TLO Co., Ltd.Inventors: Keiji Hasumi, Fumihiko Maeda, Kunitoshi Mitsumori
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Publication number: 20120135996Abstract: Disclosed is a cytoprotective agent for use with respect to ischemic damage, including as an active ingredient a triprenyl phenol compound represented by the following general formula (I), wherein X is —CHY—C(CH3)2Z, Y and Z are each independently —H or —OH, or jointly form a single bond, and R represents a hydrogen atom or a substituent with a molecular weight of 1000 or less.Type: ApplicationFiled: February 5, 2010Publication date: May 31, 2012Inventors: Kazuo Honda, Terumasa Hashimoto, Keita Shibata, Keiko Hasegawa, Keiji Hasumi
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Publication number: 20120100579Abstract: A triprenyl phenol compound represented by the following formula (II) and (III) and having a thrombolysis-enhancing activity, and an efficient method for producing the triprenyl phenol compound. In formula (II) and (III), R1 represents an aromatic group having as a substituent or as a part of a substituent at least one member selected from the group consisting of a carboxyl group, a hydroxyl group, a sulfonic acid group and a secondary amino group, or an aromatic group which comprises a secondary amino group and may comprise nitrogen; R4 in the general formula (III) represents an aromatic amino acid residue represented by the general formula (III-1) below; X represents —CHY—(CH3)2Z; and Y and Z are respectively —H or —OH or together form a single bond: (III-1) wherein R5 represents a hydroxyl group which may be present or absent; and n represents an integer of 0 or 1.Type: ApplicationFiled: January 4, 2012Publication date: April 26, 2012Applicant: TOKYO UNIVERSITY OF AGRICLATURE AND TECHNOLOGY TLO CO., LTD.Inventors: Keiji HASUMI, Yoshikazu KITANO, Hideo OHISHI, Haruki KOIDE, Keiko HASEGAWA, Ritsuko NARASAKI
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Patent number: 8110596Abstract: The present invention provides a triprenyl phenol compound represented by the following formula (II) and (III) and having a thrombolysis-enhancing activity, and an efficient method for producing the triprenyl phenol compound. In formula (II) and (III), R1 represents an aromatic group having as a substituent or as a part of a substituent at least one member selected from the group consisting of a carboxyl group, a hydroxyl group, a sulfonic acid group and a secondary amino group, or an aromatic group which comprises a secondary amino group and may comprise nitrogen; R4 in the general formula (III) represents an aromatic amino acid residue represented by the general formula (III-1) below; X represents —CHY—(CH3)2Z; and Y and Z are respectively —H or —OH or together form a single bond: (III-1) wherein R5 represents a hydroxyl group which may be present or absent; and n represents an integer of 0 or 1.Type: GrantFiled: March 20, 2007Date of Patent: February 7, 2012Assignee: Tokyo University of Agriculture and Technology TLO Co., Ltd.Inventors: Keiji Hasumi, Yoshikazu Kitano, Hideo Ohishi, Haruki Koide, Keiko Hasegawa, Ritsuko Narasaki
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Publication number: 20110092442Abstract: An anticancer agent containing BL-angiostatin as an active ingredient; and a process for producing the same. Also a method for treating cancer comprising administering to a mammal a pharmaceutically effective amount of BL-angiostatin.Type: ApplicationFiled: February 24, 2004Publication date: April 21, 2011Applicant: TTC CO., LTDInventors: Keiji Hasumi, Kosuke Shimizu, Tetsuro Yamamoto
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PHARMACEUTICAL COMPOSITION FOR TREATMENT OR PREVENTION OF NEPHRITIS AND MANUFACTURING METHOD THEREOF
Publication number: 20090270476Abstract: A pharmaceutical composition for treatment of nephritis of the present invention comprises a triprenylphenol compound as an active substance, preferably the triprenylphenol compound represented by the following general formula (1) as an active substance, and further preferably orniplabin represented as n=3 in the following general formula (1) as an active substance. general formula (1) (in formula (1) n is one of integer selected from 1 to 10). Further a manufacturing method of a pharmaceutical composition for treatment or prevention of nephritis of the present invention comprises using a triprenylphenol compound as an active substance.Type: ApplicationFiled: September 25, 2006Publication date: October 29, 2009Inventors: Keiji Hasumi, Kazumi Yagasaki -
Publication number: 20090216028Abstract: The present invention provides a triprenyl phenol compound represented by the following formula (II) and (III) and having a thrombolysis-enhancing activity, and an efficient method for producing the triprenyl phenol compound. In formula (II) and (III), R1 represents an aromatic group having as a substituent or as a part of a substituent at least one member selected from the group consisting of a carboxyl group, a hydroxyl group, a sulfonic acid group and a secondary amino group, or an aromatic group which comprises a secondary amino group and may comprise nitrogen; R4 in the general formula (III) represents an aromatic amino acid residue represented by the general formula (III-1) below; X represents —CHY—(CH3)2Z; and Y and Z are respectively —H or —OH or together form a single bond: (III-1) wherein R5 represents a hydroxyl group which may be present or absent; and n represents an integer of 0 or 1.Type: ApplicationFiled: March 20, 2007Publication date: August 27, 2009Applicant: Tokyo University of Agriculture and Technology TLO Co., LTD.Inventors: Keiji Hasumi, Yoshikazu Kitano, Hideo Ohishi, Haruki Koide, Keiko Hasegawa, Ritsuko Narasaki
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Patent number: 7476515Abstract: The present invention provides an affinity trap reactor that enables the reaction between an enzyme bound to a support and substrate to proceed efficiently without its applications being restricted by the type of enzyme and substrate used. The present invention relates to an affinity trap reactor composed of a support bound with an enzyme and a molecule that specifically binds with a substrate of the enzyme, and a single-stage process for obtaining BL-angiostatin from plasminogen contained in a biological sample, wherein a biological sample containing plasminogen is applied to an affinity trap reactor composed of a support bound with bacillolysin MA and lysine, and reacted under conditions of a temperature of 0 to 50° C. in the presence of isopropyl alcohol but in the absence of calcium ions.Type: GrantFiled: January 17, 2003Date of Patent: January 13, 2009Assignee: TTC Co., Ltd.Inventors: Keiji Hasumi, Kosuke Shimizu
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Publication number: 20080293799Abstract: The present invention relates to a liver function ameliorant containing orniplabin as an active ingredient thereof.Type: ApplicationFiled: February 17, 2006Publication date: November 27, 2008Inventors: Keiji Hasumi, Fumihiko Maeda, Kunitoshi Mitsumori
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Publication number: 20060134721Abstract: The present invention provides an affinity trap reactor that enables the reaction between an enzyme bound to a support and substrate to proceed efficiently without its applications being restricted by the type of enzyme and substrate used. The present invention relates to an affinity trap reactor composed of a support bound with an enzyme and a molecule that specifically binds with a substrate of the enzyme, and a single-stage process for obtaining BL-angiostatin from plasminogen contained in a biological sample, wherein a biological sample containing plasminogen is applied to an affinity trap reactor composed of a support bound with bacillolysin MA and lysine, and reacted under conditions of a temperature of 0 to 50° C. in the presence of isopropyl alcohol but in the absence of calcium ions.Type: ApplicationFiled: January 17, 2003Publication date: June 22, 2006Inventors: Keiji Hasumi, Kosuke Shimizu
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Patent number: 5482524Abstract: An atmospheric pressure, elevated temperature gas desorption apparatus which enables quanitiative analysis of impurities absorbed in or on the surface of a solid sample (semiconductor wafer, optical disc, etc.) is disclosed. The atmospheric pressure, elevated temperature gas desorption apparatus for desorbing impurities absorbed in or on the surface of a plate-like solid sample 18 into a carrier gas 19 in a chamber 6 under an atmospheric pressure while increasing the temperature of the solid sample 18 includes a desorption room 7A provided in the chamber 6 and connected through to a first gas supply system 1 for supplying the carrier gas 19, for desorbing impurities absorbed in or on the surface of the solid sample 18 into the carrier gas 19. A sample support room 7B is provided in the chamber 6 and is separated from the desorption room 7A by a partition member 6A. The solid sample 18 is in close contact with the partition member 6A.Type: GrantFiled: August 3, 1994Date of Patent: January 9, 1996Assignees: Hitachi, Ltd., Hitachi Tokyo Electronics Co., Ltd.Inventors: Kazuo Nakano, Kazuaki Mizokami, Keiji Hasumi, Katsuhiko Itoh, Michimasa Funabashi, Yasuhiro Mitsui, Takashi Irie, Takeshi Tajima, Sadao Matsuoka
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Patent number: 5304797Abstract: Ultra-low concentrations of impurities such as water in a highly-purified gas are analyzed by a system having an ion source chamber and a drift chamber. The ion source chamber ionizes one of a sample gas and a carrier gas to produce main component ions, and the other of the sample gas and carrier gas is introduced into the drift chamber. The invention controls the residence time of main component ions in one of the first and second chambers to be shorter than the mean reaction time of main component ions and impurity molecules of the sample gas in the one of the first and second chambers.Type: GrantFiled: February 11, 1993Date of Patent: April 19, 1994Assignees: Hitachi, Ltd., Hitachi Tokyo Electronics, Co., Ltd.Inventors: Takashi Irie, Yasuhiro Mitsui, Keiji Hasumi
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Patent number: 4996422Abstract: A mass spectrometer, including an evacuable vessle, mass separation means provided in the evacuable vessel for separating ions in accordance with the mass thereof, and ion detection means provided in the evacuable vessel for detecting ions emitted from the mass separation means to convert the emitted ions into an electric signal, in which the ion detection means includes an electron-multiplier for detecting positive ions and a photo-multiplier for detecting negative ions. According to this mass spectrometer, positive ions can be detected at high sensitivity, and negative ions are readily detected.Type: GrantFiled: June 1, 1989Date of Patent: February 26, 1991Assignees: Hitachi, Ltd., Hitachi Tokyo Electronics Co., Ltd.Inventors: Yasuhiro Mitsui, Keiji Hasumi, Shinichiro Watase, Katsumi Kuriyama, Kazuo Nakano
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Patent number: RE47684Abstract: Disclosed is a cytoprotective agent for use with respect to ischemic damage, including as an active ingredient a triprenyl phenol compound represented by the following general formula (I), wherein X is —CHY—C(CH3)2Z, Y and Z are each independently —H or —OH, or jointly form a single bond, and R represents a hydrogen atom or a substituent with a molecular weight of 1000 or less.Type: GrantFiled: April 25, 2017Date of Patent: November 5, 2019Assignee: TMS CO., LTD.Inventors: Honda Kazuo, Terumasa Hashimoto, Keita Shibata, Keiko Hasegawa, Keiji Hasumi
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Patent number: RE49351Abstract: Disclosed is a cytoprotective agent for use with respect to ischemic damage, including as an active ingredient a triprenyl phenol compound represented by the following general formula (I), wherein X is —CHY—C(CH3)2Z, Y and Z are each independently —H or —OH, or jointly form a single bond, and R represents a hydrogen atom or a substituent with a molecular weight of 1000 or less.Type: GrantFiled: September 26, 2019Date of Patent: January 3, 2023Assignee: Biogen MA Inc.Inventors: Kazuo Honda, Terumasa Hashimoto, Keita Shibata, Keiko Hasegawa, Keiji Hasumi