Patents by Inventor Keiji Hemmi
Keiji Hemmi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6727245Abstract: Heterobicyclic derivatives of the formula: wherein R1 is aryl which may have suitable substituent(s), ar(lower)alkyl which may have suitable substituent(s), halo(lower)alkyl, protected carboxy(lower)alkyl, acyl(lower)alkyl, heterocyclic group or heterocyclic(lower)alkyl which may have suitable substituent(s), R2 is aryl which may have suitable substituent(s) or heterocyclic group, and R3 is hydrogen, lower alkoxy or arylthio, and a pharmaceutically acceptable salt thereof which are useful as a medicament.Type: GrantFiled: January 18, 2002Date of Patent: April 27, 2004Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Norihiko Shimazaki, Shinya Watanabe, Akihiko Sawada, Keiji Hemmi
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Publication number: 20040063959Abstract: The present invention relates to a novel fatty acid derivative of the following formula: 1Type: ApplicationFiled: September 22, 2003Publication date: April 1, 2004Inventors: Naoki Fukami, Seiji Yoshimura, Keisuke Imai, Keiji Hemmi, Mitsue Hemmi, Keiichiro Hemmi, Yusuke Hemmi
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Publication number: 20020169326Abstract: The present invention relates to a novel fatty acid derivative of the following formula: 1Type: ApplicationFiled: May 6, 2002Publication date: November 14, 2002Applicant: FUJISAWA PHARMACEUTICAL COMPANY, LTD.Inventors: Naoki Fukami, Seiji Yoshimura, Keisuke Imai, Keiji Hemmi, Mitsue Hemmi, Keiichiro Hemmi, Yusuke Hemmi
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Publication number: 20020107251Abstract: Heterobicyclic derivatives of the formula: 1Type: ApplicationFiled: January 18, 2002Publication date: August 8, 2002Applicant: FUJISAWA PHARMACEUTICAL CO., LTD.Inventors: Norihiko Shimazaki, Shinya Watanabe, Akihiko Sawada, Keiji Hemmi, Mitsue Hemmi, Keiichiro Hemmi, Yusuke Hemmi
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Patent number: 6426345Abstract: Heterobicyclic derivatives of the formula: wherein R1 is aryl which may have suitable substituent(s), ar(lower)alkyl which may have suitable substituent(s), halo(lower)alkyl, protected carboxy(lower)alkyl, acyl(lower)alkyl, heterocyclic group or heterocyclic(lower)alkyl which may have suitable substituent(s), R2 is aryl which may have suitable substituent(s) or heterocyclic group, and R3 is hydrogen, lower alkoxy or arylthio, and a pharmaceutically acceptable salt thereof which are useful as a medicament.Type: GrantFiled: January 30, 1998Date of Patent: July 30, 2002Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Norihiko Shimazaki, Shinya Watanabe, Akihiko Sawada, Keiji Hemmi
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Publication number: 20020019416Abstract: 1 The present invention relates to a novel fatty acid derivative of formula (I), wherein R1 is acyl group; R2 is acyl(lower)alkyl; R3 is hydrogen, aryl(lower)alkyl, etc.; R4 is acyl(lower)alkyl; and X is —O—, —NH— or formula (II) [wherein R5 is lower alkyl, etc.]; and a pharmaceutically acceptable salt thereof, which is useful as a medicament; the processes for the preparation of said fatty acid derivative or a salt thereof; a pharmaceutical composition comprising said fatty acid derivative or a pharmaceutically acceptable salt thereof; etc.Type: ApplicationFiled: April 20, 1998Publication date: February 14, 2002Inventors: NAOKI FUKAMI, SEIJI YOSHIMURA, KEISUKE IMAI, KEIJI HEMMI, MITSUE HEMMI, KEIICHIRO HEMMI, YUSUKE HEMMI
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Patent number: 6211242Abstract: This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc. and represented by the general formula (I): wherein R1 is aryl optionally substituted with lower alkyl, etc., R2 is lower alkyl, etc., R3 is hydrogen, etc., R4 is aryl, etc., X is CH or N, and Y is CH or N, and pharmaceutically acceptable salts thereof, to processes for the preparation thereof and to a pharmaceutical composition comprising the same.Type: GrantFiled: January 30, 1998Date of Patent: April 3, 2001Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Hiroyuki Setoi, Takehiko Ohkawa, Tatsuya Zenkoh, Keiji Hemmi, Hirokazu Tanaka
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Patent number: 6207686Abstract: A compound of formula (I), in which: R1 is lower alkyl, cyclo(lower)alkyl, optionally substituted aryl, optionally substituted heterocyclic group, cyclo(lower)alkyl(lower)alkyl, or ar(lower)alkyl; R2 is hydrogen, hydroxy or protected hydroxy; R3 is lower alkyl, aryl, ar(lower)alkyl or optionally substituted heterocyclic(lower)alkyl; R4 is carboxy, protected carboxy or lower alkylsufonylcarbamoyl; R5 is hydrogen or lower alkyl; R6 is hydrogen or heterocyclic group; A is a single bond or lower alkylene, and Ar is optionally substituted aryl, or pharmaceutically acceptable salts thereof, having endothelin antagonistic activity.Type: GrantFiled: June 20, 1997Date of Patent: March 27, 2001Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masahiro Neya, Tatsuya Zenkoh, Hitoshi Sawada, Chiyoshi Kasahara, Masayoshi Murata, Keiji Hemmi
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Patent number: 6110933Abstract: The present invention relates to a novel fatty acid derivative of the following formula: ##STR1## wherein R.sup.1 is acyl group, etc.;R.sup.2 is acyl(lower)alkyl;R.sup.3 is lower alkyl, etc.;R.sup.4 is hydrogen, etc.; andX is --O--, etc;and a pharmaceutically acceptable salt thereof, which is useful as a medicament; the processes for the preparation of said fatty acid derivative or a salt thereof; a pharmaceutical composition comprising said fatty acid derivative or a pharmaceutically acceptable salt thereof; etc.Type: GrantFiled: November 12, 1996Date of Patent: August 29, 2000Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Shigehiro Takase, Nobuharu Shigematsu, Seiji Yoshimura, Satoshi Okada, Keiji Hemmi, deceased, Hirokazu Tanaka, Takanao Otsuka, Yasuhisa Tsurumi, Masanori Okamoto, Masakuni Okuhara, Naoki Fukami
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Patent number: 5888972Abstract: A compound of the formula: ##STR1## in which R.sup.4 is acyl,R.sup.5 is lower alkyl,R.sup.6 is optionally substituted ar(lower)alkyl or optionally substituted heterocyclic-(lower)alkyl,R.sup.7 is lower alkyl or lower alkylthio(lower)alkyl,R.sup.8 is carboxy or protected carboxy,A is lower alkylene,Z is a group of the formula: ##STR2## wherein R.sup.1 is hydrogen, lower alkyl, common amino-protective group or optionally substituted ar(lower)alkyl,R.sup.2 is hydrogen, lower alkyl, optionally substituted ar(lower)alkyl, optionally substituted heterocyclic-(lower)alkyl, optionally substituted cyclo(lower)alkyl(lower)alkyl, common amino-protective group, amino(or protected amino)(lower)alkyl, optionally substituted heterocyclic-carbonyl or cyclo(lower)alkyl, andR.sup.3 is optionally substituted heterocyclic(lower)alkyl, andm is an integer of 0 to 2,or pharmaceutically acceptable salts thereof, useful as endothelin antagonist.Type: GrantFiled: June 24, 1997Date of Patent: March 30, 1999Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Keiji Hemmi, deceased, Masahiro Neya, Naoki Fukami, Natsuko Kayakiri, Hirokazu Tanaka
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Patent number: 5656604Abstract: Peptide compounds of the formula (I') ##STR1## in which R.sup.1 is acyl,R.sup.2 is lower alkyl, cyclo(lower)alkyl(lower)alkyl or optionally substituted heterocyclic(lower)alkyl,R.sup.3 is optionally substituted heterocyclic(lower)alkyl or optionally substituted ar(lower)alkyl,R.sup.4 is lower alkyl, amino(lower)alkyl, protected amino(lower)alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl or optionally substituted heterocyclic(lower)alkyl,R.sup.5 is carboxy, protected carboxy, carboxy(lower)alkyl or protected carboxy(lower)alkyl,R.sup.6 is hydrogen, lower alkyl, C.sub.6-10 ar(lower)alkyl amino(lower)alkyl, protected amino(lower)alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl, or heterocyclic(lower)alkyl,R.sup.7 is hydrogen or lower alkyl, andA is --O--, --NH--, lower alkylimino or lower alkylene, or a pharmaceutically acceptable salt thereof are disclosed. The compounds can be used to treat and prevent endothelin mediated diseases such as hypertension.Type: GrantFiled: April 17, 1995Date of Patent: August 12, 1997Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Keiji Hemmi, Masahiro Neya, Naoki Fukami, Masashi Hashimoto, Hirokazu Tanaka, Natsuko Kayakiri
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Patent number: 5538950Abstract: A compound of the formula: ##STR1## in which R.sup.3 is hydrogen or lower alkyl, R.sup.4 is pyridyl (lower) alkyl; andR.sup.1, R.sup.2, R.sup.5 and A are defined in the description;or a pharmaceutically acceptable salt thereof, which have endothelin antagonistic activity.Type: GrantFiled: May 12, 1994Date of Patent: July 23, 1996Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Keiji Hemmi, Masahiro Neya, Naoki Fukami, Masashi Hashimoto, Hirokazu Tanaka, Natsuko Kayakiri
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Patent number: 5521170Abstract: Compounds having the structure below ##STR1## and pharmaceutically acceptable salts thereof exhibit vasopressin antagonistic activity, vasodilating activity, hypotensive activity, activity for inhibiting saccharide release in the liver, activity for inhibiting growth of mesagium cells, water diuretic activity, platelet agglutination inhibitory activity, oxytocin antagonistic activity and the like, and are useful in treating or preventing hypertension, heart failure, renal insufficiency, edema, ascites, vasopressin parasecretion syndrome, hepatocirrhosis, hyponatremia, hypokalemia, diabetic or circulation disorder, oxytocin related diseases and the like.Type: GrantFiled: March 31, 1994Date of Patent: May 28, 1996Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Hiroyuki Setoi, Takehiko Ohkawa, Tatsuya Zenkoh, Keiji Hemmi, Hirokazu Tanaka
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Patent number: 5491132Abstract: This invention relates to new amino acid derivatives and pharmaceutically acceptable salts thereof, wherein the amino acid derivatives are useful in the treatment and/or prevention of hypertension, heart failure, renal diseases or glaucoma.Type: GrantFiled: February 28, 1994Date of Patent: February 13, 1996Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Keiji Hemmi, Masahiro Neya, Hiroshi Marusawa, Shinya Watanabe, Masashi Hashimoto
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Patent number: 5430025Abstract: Trifluoromethylketone compounds of the formula: ##STR1## wherein R.sup.1 is C.sub.1-6 alkyl which has one or two substituents selected from carboxy, esterified carboxy and di-C.sub.1-6 alkylcarbamoyl; phenyl(C.sub.1-6)alkyl, the phenyl moiety of which may have halogen or nitro or amino substituents and the alkyl moiety of which may have carboxy or esterified carboxy substituents; halo-phenyl; morpholino; or morpholino(C.sub.1-6)alkyl, R.sup.2 and R.sup.3 are each C.sub.1-6 alkyl, X is --or --NH--, and ##STR2## and pharmaceutically acceptable salts thereof are useful for inhibiting human elastase.Type: GrantFiled: November 30, 1993Date of Patent: July 4, 1995Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Keiji Hemmi, Ichiro Shima, Keisuke Imai, Hirokazu Tanaka
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Patent number: 5430022Abstract: Peptide compounds of the formula (I') ##STR1## in which R.sup.1 is acyl,R.sup.2 is lower alkyl, cyclo(lower)alkyl(lower)alkyl or optionally substituted heterocyclic(lower)alkyl,R.sup.3 is optionally substituted heterocyclic(lower)alkyl or optionally substituted ar(lower)alkyl,R.sup.4 is lower alkyl, amino(lower)alkyl, protected amino(lower)alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl or optionally substituted heterocyclic(lower)alkyl,R.sup.5 is carboxy, protected carboxy, carboxy(lower)alkyl or protected carboxy(lower)alkyl,R.sup.6 is hydrogen, lower alkyl, C.sub.6-10 ar(lower)alkyl amino(lower)alkyl, protected amino(lower)alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl, or heterocyclic(lower)alkyl,R.sup.7 is hydrogen or lower alkyl, andA is --O--, --NH--, lower alkylimino or lower alkylene, or a pharmaceutically acceptable salt thereof are disclosed. The compounds can be used to treat and prevent endothelin mediated diseases such as hypertension.Type: GrantFiled: July 6, 1993Date of Patent: July 4, 1995Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Keiji Hemmi, Masahiro Neya, Naoki Fukami, Masashi Hashimoto, Hirokazu Tanaka, Natsuko Kayakiri
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Patent number: 5296591Abstract: The trifluoromethylketone derivatives (I) and pharmaceutically acceptable salts thereof have a human leukocyte elastase inhibiting activity and are useful as human leukocyte elastase inhibitors for treating or preventing degenerative diseases. The trifluoromethylketone derivatives (I) have the following formula: ##STR1## wherein R.sup.1 is C.sub.1-6 alkyl which has one or two substituents selected from carboxy, esterified carboxy and di-C.sub.1-6 alkylcarbamoyl; phenyl(C.sub.1-6) alkyl, the phenyl moiety of which may have halogen or nitro or amino substituents and the alkyl moiety of which may have carboxy or esterified carboxy substituents; halo-phenyl; morpholino; or morpholino(C.sub.1-6) alkyl,R.sup.2 and R.sup.3 are each C.sub.1-6 alkyl,X is -- or --NH--, andY is ##STR2## and pharmaceutically acceptable salts thereof.Type: GrantFiled: December 12, 1991Date of Patent: March 22, 1994Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Keiji Hemmi, Ichiro Shima, Keisuke Imai, Hirokazu Tanaka
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Patent number: 5284828Abstract: Novel peptides of the formula (I") ##STR1## in which R.sup.1 is hydrogen or acyl,R.sup.2.sub.c is lower alkyl,R.sup.3.sub.c is optionally N-substituted indolylmethyl,R.sup.4 is hydrogen, lower alkyl, C.sub.6-10 ar(lower)alkyl, amino(lower)alkyl, protected amino (lower)alkyl, carboxy(lower)alkyl, protected carboxy(lower)alkyl or optionally substituted heterocyclic (lower)alkyl,R.sup.5 is carboxy, protected carboxy, carboxy(lower)alkyl or protected carboxy(lower)alkyl,R.sup.7 is hydrogen or lower alkyl, andA is --O--, --NH--, lower alkylamino or lower alkylene,or a pharmaceutically acceptable salt thereof are disclosed.Additionally, the preparation of such peptides is described. The peptides are used to treat endothelin mediated diseases such as hypertension.Type: GrantFiled: May 7, 1991Date of Patent: February 8, 1994Assignee: Fujisawa Pharmaceutical Co. Ltd.Inventors: Keiji Hemmi, Masahiro Neya, Naoki Fukami, Masashi Hashimoto, Hirokazu Tanaka, Hatsuko Kayakiri
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Patent number: 5223489Abstract: A compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl optionally substituted aryl; or amino optionally substituted; andR.sup.2 is hydrogen or lower alkyl; orR.sup.1 and R.sup.2 are taken together with the attached nitrogen atom to form a heterocyclic group optionally substituted;R.sup.3 is hydrogen or lower alkyl; andR.sup.Type: GrantFiled: January 30, 1992Date of Patent: June 29, 1993Assignee: Ujisawa Pharmaceutical Co., Ltd.Inventors: Keiji Hemmi, Masahiro Neya, Hiroshi Marusawa, Keisuke Imai, Natsuko Kayakiri, Masashi Hashimoto
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Patent number: 5187195Abstract: Anthraquinone compounds of the formula: ##STR1## wherein: R.sup.1 is hydrogen, hydroxy or acyloxy,R.sup.2 is hydrogen or acyl,R.sup.3 is acyl,R.sup.4 is hydrogen or acyl,R.sup.5 is hydrogen or acyl,R.sup.6 is hydrogen or acyl, andR.sup.7 is hydrogen or acylhave been found to possess endothelin antagonistic properties and are producible by various synthetic and fermentation processes.Type: GrantFiled: June 26, 1990Date of Patent: February 16, 1993Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Nobutaka Oohata, Motoaki Nishikawa, Sumio Kiyoto, Shigehiro Takase, Keiji Hemmi, Hidetsugu Murai, Masakuni Okuhara