Patents by Inventor Keiji Kondo
Keiji Kondo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110163625Abstract: A stator which may be employed in an electric rotating machine. The stator includes a stator winding which includes in-slot portions disposed in slots of a stator core. The in-slot portions are arrayed in each of the slots in a form of multiple layers aligned in a radial direction of the stator core. The stator winding is made up of a first winding and a second winding which are connected together through a joint. The first winding is defined by a portion of the stator winding between the joint and an end of the stator winding which is to be connected to an external. The second winding includes the in-slot portion placed within at least one of the slots as an outermost layer that is one of the layers placed most outwardly in the radial direction of the stator core. This results in a great decrease in leakage current.Type: ApplicationFiled: January 5, 2011Publication date: July 7, 2011Applicant: DENSO CORPORATIONInventors: Akira FUKUSHIMA, Keiji Kondo, Akito Akimoto, Takeo Maekawa, Makoto Taniguchi, Shin Kusase
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Publication number: 20100080862Abstract: It is intended to provide compositions and foods for use in the treatment, prophylaxis, or amelioration of diseases or symptoms which can be treated, prevented or ameliorated by activating PPAR, in particular, insulin resistant diabetes and hyperlipidemia. Namely, medicinal compositions usable in treating, preventing or improving diseases or symptoms which can be treated, prevented or ameliorated by activation PPAR which contain humulones, isohumulones or lupulones or pharmaceutically acceptable salts or solvates thereof.Type: ApplicationFiled: September 10, 2009Publication date: April 1, 2010Inventors: Hiroaki YAJIMA, Yutaka Miura, Daisuke Fujiwara, Hideharu Odai, Keiji Kondo, Hajime Nozawa
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Patent number: 7195915Abstract: Protein synthesis inhibitor resistance genes (typified by a cycloheximide resistance gene) are capable of imparting resistance to a protein synthesis inhibitor (typified by cycloheximide) to animal cells sensitive to the inhibitor. The genes have a sequence mutated by substitution in a gene encoding a ribosome-constituting protein derived from an animal. The genes may be placed in recombinant vectors, including expression vectors containing the gene together with a foreign protein structural gene.Type: GrantFiled: November 23, 2005Date of Patent: March 27, 2007Assignee: Kirin Beer Kabushiki KaishaInventors: Elisa Misawa, Hiroaki Yajima, Keiji Kondo
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Publication number: 20060233902Abstract: It is intended to provide compositions and foods for use in the treatment, prophylaxis, or amelioration of diseases or symptoms which can be treated, prevented or ameliorated by activating PPAR, in particular, insulin resistant diabetes and hyperlipidemia. Namely, medicinal compositions usable in treating, preventing or improving diseases or symptoms which can be treated, prevented or ameliorated by activation PPAR which contain humulones, isohumulones or lupulones or pharmaceutically acceptable salts or solvates thereof.Type: ApplicationFiled: February 14, 2003Publication date: October 19, 2006Applicant: Kirin Beer Kabushiki KaishaInventors: Hiroaki Yajima, Yutaka Miura, Daisuke Fujiwara, Hideharu Odai, Keiji Kondo, Hajime Nozawa
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Publication number: 20060147568Abstract: According to the present invention, there is provided a blood pressure-lowering agent, a vascular flexibility-ameliorating agent and foods having these functions imparted thereto, which are comprising isohumulones or a hop extract and/or an isomerized hop extract as an active ingredient.Type: ApplicationFiled: January 16, 2004Publication date: July 6, 2006Inventors: Akihiko Takeuchi, Taku Sato, Hiroaki Yajima, Yutaka Miura, Keiji Kondo, Aruto Yoshida, Kiyoshi Yoshida, Junko Tomita
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Patent number: 7064194Abstract: Protein synthesis inhibitor resistance genes (typified by a cycloheximide resistance gene) are capable of imparting resistance to a protein synthesis inhibitor (typified by cycloheximide) to animal cells sensitive to the inhibitor. The genes have a sequence mutated by substitution in a gene encoding a ribosome-constituting protein derived from an animal. The genes may be placed in recombinant vectors, including expression vectors containing the gene together with a foreign protein structural gene.Type: GrantFiled: March 8, 2002Date of Patent: June 20, 2006Assignee: Kirin Beer Kabushiki KaishaInventors: Elisa Misawa, Hiroaki Yajima, Keiji Kondo
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Publication number: 20060078992Abstract: Protein synthesis inhibitor resistance genes (typified by a cycloheximide resistance gene) are capable of imparting resistance to a protein synthesis inhibitor (typified by cycloheximide) to animal cells sensitive to the inhibitor. The genes have a sequence mutated by substitution in a gene encoding a ribosome-constituting protein derived from an animal. The genes may be placed in recombinant vectors, including expression vectors containing the gene together with a foreign protein structural gene.Type: ApplicationFiled: November 23, 2005Publication date: April 13, 2006Inventors: Elisa Misawa, Hiroaki Yajima, Keiji Kondo
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Publication number: 20040242512Abstract: The present invention is intended to provide a technique for selecting cells, into which a gene has been transfected in a stable state, by using a novel drug resistant gene as a selection marker, and a technique for obtaining cells in which a gene is highly expressed.Type: ApplicationFiled: September 8, 2003Publication date: December 2, 2004Inventors: Elisa Misawa, Hiroaki Yajima, Keiji Kondo
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Patent number: 6821749Abstract: The production of carotenoid is accomplished using a DNA molecule that encodes a polypeptide as obtained from Haematococcus pluvialis, Phaffia rhodozyma, or Saccharomyces cerevisiae, having isopentonyl pyrophosphate (IPP) isomerase activity, or DNA molecule having a nucleotide sequence that hybridizes thereto. In particular, one can introduce such a DNA molecule into a carotenoid-producing microorganism, culture the microorganism thus transformed, and then obtain carotenoids in the culture broth and cells.Type: GrantFiled: November 12, 1996Date of Patent: November 23, 2004Assignee: Kirin Beer Kabushiki KaishaInventors: Susumu Kajiwara, Norihiko Misawa, Keiji Kondo
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Patent number: 6610514Abstract: An object of the present invention is to provide a vector which can be integrated into a yeast chromosome in a high number of copies. Another object of the present invention is to provide a modified vector which can be integrated into the yeast chromosome in a high number of copies and of which expression units stably maintain on the chromosome. The vector according to the present invention comprises a marker gene for selecting transformants, a shortened promoter sequence which is operably linked to the marker gene and a sequence homologous to the chromosomal DNA of Candida utilis, and optionally a heterologous gene or a gene derived from C. utilis, wherein the vector is linearized by cleaving within said homologous DNA sequence or at both ends of the homologous DNA sequence with restriction enzymes, and wherein the heterologous gene or the gene derived from C. utilis can be integrated into the chromosomal DNA of C. utilis by homologous recombination.Type: GrantFiled: July 20, 2001Date of Patent: August 26, 2003Assignee: Kirin Beer Kabushiki KaishaInventors: Keiji Kondo, Yutaka Miura
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Publication number: 20020115220Abstract: An object of the present invention is to provide a vector which can be integrated into a yeast chromosome in a high number of copies. Another object of the present invention is to provide a modified vector which can be integrated into the yeast chromosome in a high number of copies and of which expression units stably maintain on the chromosome. The vector according to the present invention comprises a marker gene for selecting transformants, a shortened promoter sequence which is operably linked to the marker gene and a sequence homologous to the chromosomal DNA of Candida utilis, and optionally a heterologous gene or a gene derived from C. utilis, wherein the vector is linearized by cleaving within said homologous DNA sequence or at both ends of the homologous DNA sequence with restriction enzymes, and wherein the heterologous gene or the gene derived from C. utilis can be integrated into the chromosomal DNA of C. utilis by homologous recombination.Type: ApplicationFiled: July 20, 2001Publication date: August 22, 2002Inventors: Keiji Kondo, Yutaka Miura
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Patent number: 6423510Abstract: This invention relates to a promoter for dihydroxyacetone synthase gene from Candida boidinii; an expression cassette or vector comprising the promoter and a heterologous gene; a transformant transformed with this vector; and a method for producing an expression product of the heterologous gene which comprises culturing the transformant to express the heterologous gene.Type: GrantFiled: August 18, 2000Date of Patent: July 23, 2002Assignee: Kirin Beer Kabushiki KaishaInventors: Toshihiro Komeda, Keiji Kondo, Nobuo Kato, Yasuyoshi Sakai
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Patent number: 6284534Abstract: An object of the present invention is to provide a vector which can be integrated into a yeast chromosome in a high number of copies. Another object of the present invention is to provide a modified vector which can be integrated into the yeast chromosome in a high number of copies and of which expression units stably maintain on the chromosome. The vector according to the present invention comprises a marker gene for selecting transformants, a shortened promoter sequence which is operably linked to the marker gene and a sequence homologous to the chromosomal DNA of Candida utilis, and optionally a heterologous gene or a gene derived from C. utilis, wherein the vector is linearized by cleaving within said homologous DNA sequence or at both ends of the homologous DNA sequence with restriction enzymes, and wherein the heterologous gene or the gene derived from C. utilis can be integrated into the chromosomal DNA of C. utilis by homologous recombination.Type: GrantFiled: February 23, 1999Date of Patent: September 4, 2001Assignee: Kirin Beer Kabushiki KaishaInventors: Keiji Kondo, Yutaka Miura
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Patent number: 6150130Abstract: Disclosed are the following DNA strands relating to the synthesis of keto group-containing xanthophylls such as astaxanthin and the like, and the techniques relating to the production of xanthophylls by genetic engineering:A DNA strand having a nucleotide sequence which encodes a polypeptide having an enzyme activity for converting a methylene group at the 4-position of a .beta.-ionone ring into a keto group.A DNA strand having a nucleotide sequence which encodes a polypeptide having an enzyme activity for converting a methylene group at the 4-position of a 3-hydroxy-.beta.-ionone ring into a keto group.A DNA strand having a nucleotide sequence which encodes a polypeptide having an enzyme activity for adding a hydroxyl group to the 3-carbon of a 4-keto-.beta.-ionone ring.It is possible to produce a variety of xanthophylls such as canthaxanthin, astaxanthin and the like by introducing the DNA strands into an appropriate microorganism such as Escherichia coli and the like.Type: GrantFiled: June 18, 1999Date of Patent: November 21, 2000Assignees: Kirin Beer Kabushiki Kaisha, Marine Biotechnology Institute Co., Ltd.Inventors: Norihiko Misawa, Keiji Kondo, Susumu Kajiwara, Akihiro Yokoyama
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Patent number: 5972690Abstract: Disclosed are the following DNA strands relating to the synthesis of keto group-containing xanthophylls such as astaxanthin and the like, and the techniques relating to the production of xanthophylls by genetic engineering:A DNA strand having a nucleotide sequence which encodes a polypeptides having and enzyme activity for converting a methylene group at the 4-position of a .beta.-ionone ring into a keto group.A DNA strand having a nucleotide sequence which encodes a polypeptide having an enzyme activity for converting a methylene group at the 4-position of a 3-hydroxy-.beta.-ionone ring into a keto group.A DNA strand having a nucleotide sequence which encodes a polypeptide having an enzyme activity for adding a hydroxyl group to the 3-carbon of a 4-keto-.beta.-ionone ring.It is possible to produce a variety of xanthophylls such as canthaxanthin, astaxanthin and the like by introducing the DNA strands into an appropriate microorganism such as Escherichia coli and the like.Type: GrantFiled: January 13, 1998Date of Patent: October 26, 1999Assignees: Kirin Beer Kabushiki Kaisha, Marine Biotechnology Institute Co., LtdInventors: Norihiko Misawa, Keiji Kondo, Susumu Kajiwara, Akihiro Yokoyama
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Patent number: 5910433Abstract: DNA sequences are described that encode genes for synthesizing ketocarotenoids such as astaxanthin. The DNA sequences, microorganisms containing them and encoded polypeptides are described. Also described are methods to obtain related sequences and to make host cells that contain such sequences. These genes and methods are useful to impart red coloration during culture of fish and crustaceans, as coloring in food, and as antioxidants.Type: GrantFiled: April 23, 1996Date of Patent: June 8, 1999Assignee: Kirin Beer Kabushiki KaishaInventors: Susumu Kajiwara, Norihiko Misawa, Keiji Kondo
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Patent number: 5849524Abstract: An reproducible transformation system of a yeast of Candida utilis, a process for expressing a heterologous gene in the transformation system, a vector which can be used in the transformation system and the expression method, and a novel DNA group are disclosed. In particular, the process for expressing a heterologous gene in Candida utilis comprises transforming Candida utilis with a vector comprising a drug-resistance marker, a sequence homologous to the chromosomal DNA of the Candida utilis yeast, and the heterologous gene, culturing the transformant, and isolating the expression product of the heterologous gene.Type: GrantFiled: May 24, 1996Date of Patent: December 15, 1998Assignee: Kirin Beer Kabushiki KaishaInventors: Keiji Kondo, Susumu Kajiwara, Norihiko Misawa
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Patent number: 5811273Abstract: Disclosed are the following DNA strands relating to the synthesis of keto group-containing xanthophylls such as astaxanthin and the like, and the techniques relating to the production of xanthophylls by genetic engineering:A DNA strand having a nucleotide sequence which encodes a polypeptide having an enzyme activity for converting a methylene group at the 4-position of .beta.-ionone ring into a keto group.A DNA strand having a nucleotide sequence which encodes a polypeptide having an enzyme activity for converting a methylene group at the 4-position of a 3-hydroxy-.beta.-ionone ring into a keto group.A DNA strand having a nucleotide sequence which encodes a polypeptide having an enzyme activity for adding a hydroxyl group to the 3-carbon of a 4-keto-.beta.-ionone ring.It is possible to produce a variety of xanthophylls such as canthaxanthin, astaxanthin and the like by introducing the DNA strands into an appropriate microorganism such as Escherichia coli and the like.Type: GrantFiled: September 23, 1996Date of Patent: September 22, 1998Assignees: Kirin Beer Kabushiki Kaisha, Marine Biotechnology Institute Co., Ltd,Inventors: Norihiko Misawa, Keiji Kondo, Susumu Kajiwara, Akihiro Yokoyama
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Patent number: 5470971Abstract: Genes (and portions thereof) which are stress-inducible, e.g., by cold-shock which encode useful proteins. The proteins contribute to confer thermo-tolerance and/or contribute to confer low temperature tolerance to organisms, like eucaryotes or procaryotes. Typical genes encoding such proteins and homologous genes encoding proteins with equivalent properties are discussed. Nucleotide sequences encoding such proteins, recombinant replicable expression vehicles which comprise DNA constructs which encode such proteins and competent transformed organisms like eucaryotes are discussed. The production of valuable fermentation products and of biologically active proteins under conditions outside the normal or optimum physiological growth conditions are described.Type: GrantFiled: March 11, 1991Date of Patent: November 28, 1995Assignee: The University of Medicine and Dentistry of New JerseyInventors: Keiji Kondo, Masayori Inouye
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Patent number: 4600129Abstract: A chemicals spreader to be carried on the back of an operator has a pack board which has a plurality of grooves provided on the front side thereof for exhausting air. The air is supplied by a fan which is to make a mixture of air and chemicals. The chemicals spreader also has a horizontal frame having a plurality of holes for exhausting air toward the back of the operator.Type: GrantFiled: January 30, 1984Date of Patent: July 15, 1986Assignee: Komatsu Zenoah & Co.Inventor: Keiji Kondo