Abstract: A pyridazinone derivative compound shown by the following formula (I): wherein R1 is selected from hydrogen, etc.; R2 is selected from substituted or unsubstituted aryl, etc.; R3 is hydrogen, etc.; p is 0, 1 or 2; R4 and R5, are each hydrogen, etc.; R6 and R7, are taken together to form a group of the formula: wherein R8 is hydrogen; X is selected from oxygen, etc; R10 is selected from hydrogen, etc.; R11 is selected from hydrogen, etc.; R12 is selected from hydrogen, etc.; R13 is selected from hydrogen, etc.; R14 is selected from hydrogen, etc.; m and n are each 0, 1, or 2, or a pharmaceutically acceptable salt thereof, which is useful as a medicament.

Abstract: The present invention provides a compound of the formula [I]: wherein R1 is lower alkyl, etc. and R2 is hydrogen, etc., or R1 and R2 are bonded together to form lower alkylene; R3 is a group represented by wherein R6 and R7 are independently optionally protected amino, etc.; m and n are independently an integer of 0 to 6; R8 and R9 are independently optionally protected amino, etc., and q and r are independently an integer of 0 to 6, or R8 and R9, together with the adjacent alkylene(s) and the nitrogen atom, form saturated nitrogen-containing heterocycle optionally having substituent(s); R4 is lower alkyl, etc.; and R5 is amino, etc., or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl or hydroxy(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene; R is -A-R6 wherein A is bond, —NHCO—(CH2CO)n—, lower alkylene, —NH—CO—CO— or the like, and R6 is wherein R7, R8, R9 and R10 are independently amino, guanidino, amidino or the like; R4 is carboxy or protected carboxy; and R5 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.

Abstract: The present invention relates to a compound of the formula [I]: wherein A is lower alkylene or lower alkenylene; R1 is lower alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, amino(lower)alkyl or protected amino(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene; R3 and R5 are independently amino or protected amino; and R4 is carboxy or protected carboxy, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.

Abstract: The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl, hydroxy(lower)alkyl or halo(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene or lower alkenylene; R3 is hydrogen or lower alkyl; R4 is R5 is carboxy or protected carboxy; and R6 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.

Abstract: The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl, hydroxy(lower)alkyl or halo(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene or lower alkenylene; R3 is hydrogen or lower alkyl; R4 is R5 is carboxy or protected carboxy; and R6 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.

Abstract: In a manifold valve, a part housing chamber and a fist recessed portion are provided to a casing of a selector valve, position sensors for detecting an operating position of a spool are housed in the part housing chamber, a first relay connector connected to both the position sensors and pilot valves is housed in the first recessed portion, a second recessed portion corresponding to the first recessed portion and a substrate housing chamber are provided to a manifold base, a second relay connector to be electrically connected to the first relay connector by mounting the selector valve onto a placing face is housed in the second recessed portion, and a main wiring substrate electrically connected to the second relay connector is housed in the substrate housing chamber.

Abstract: The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl or hydroxy(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene; R is -A-R6 wherein A is bond, —NHCO—(CH2CO)n—, lower alkylene, —NH—CO—CO— or the like, and R6 is wherein R7, R8, R9 and R10 are independently amino, guanidino, amidino or the like; R4 is carboxy or protected carboxy; and R5 is amino or protected amino, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.

Abstract: The present invention relates to a compound of the formula [I]: wherein R1 is lower alkyl which may have suitable substituent(s), R2 is amino, protected amino or guanidino, R3 is carboxy or protected carboxy, R4 is amino or protected amino, and A is lower alkylene, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.

Abstract: The present invention relates to a compound of the formula [I]: wherein A is lower alkylene or lower alkenylene; R1 is lower alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, amino(lower)alkyl or protected amino(lower)alkyl, and R2 is hydrogen or amino protecting group, or R1 and R2 are bonded together and form lower alkylene; R3 and R5 are independently amino or protected amino; and R4 is carboxy or protected carboxy, or a pharmaceutically acceptable salt thereof, a process for preparing a compound of the formula [I], and a pharmaceutical composition comprising a compound of the formula [I] in admixture with a pharmaceutically acceptable carrier.

Abstract: The present invention relates to a compound of the formula [I]: 1

Abstract: Provided are a propenohydroxamic acid derivative represented by the following formula (1): 1

Abstract: In a manifold valve, a part housing chamber and a fist recessed portion are provided to a casing of a selector valve, position sensors for detecting an operating position of a spool are housed in the part housing chamber, a first relay connector connected to both the position sensors and pilot valves is housed in the first recessed portion, a second recessed portion corresponding to the first recessed portion and a substrate housing chamber are provided to a manifold base, a second relay connector to be electrically connected to the first relay connector by mounting the selector valve onto a placing face is housed in the second recessed portion, and a main wiring substrate electrically connected to the second relay connector is housed in the substrate housing chamber.

Abstract: To make it easy to mount magnets for monitoring a switched state of a valve element in a solenoid valve and to easily mount magnetometric sensors for sensing an approach of the magnet in a state of excellent water resistance and dustproof property. In a solenoid valve for switching a direction of a flow of pressure fluid by driving the solenoid valve by pilot fluid pressure, ring-shaped magnets 13A and 13B are fitted with small-diameter portions 11a formed at end portions of a valve element 11 and is fixed by press fitting and engaging caps 14A and 14B forming faces to be in contact with pistons 14A and 14B at the valve element ends. A housing chamber 30 is formed outside a valve hole 10a in a valve body 10 and in a position close to the magnets, magnetometric sensors 31A and 31B are housed in the housing chamber 30, and a cover 35 is mounted to the housing chamber 30.

Abstract: Disclosed are 5,11-Dihydrodibenzo[b,e][1,4]oxazepine derivatives such as (R)-(+)-5,11-dihydro-5-[1-(4-methoxyphenethyl)-2-pyrrolidinylmethyl]dibenzo[b,e][1,4]oxazepine and (R)-(+)-5,11-dihydro-5-[1-(4-fluorophenethyl)-2-pyrrolidinylmethyl]dibenzo[b,e][1,4]oxazepine, stereoisomers thereof, pharmacologically acceptable salts thereof, or hydrates thereof and a pharmaceutical composition conating the 5,11-Dihydrodibenzo[b,e][1,4]oxazepine derivatives. The derivatives have an excellent activity of improving a digestive tract moving function and are free of side effect.

Abstract: To make it easy to mount magnets for monitoring a switched state of a valve element in a solenoid valve and to easily mount magnetometric sensors for sensing an approach of the magnet in a state of excellent water resistance and dustproof property. In a solenoid valve for switching a direction of a flow of pressure fluid by driving the solenoid valve by pilot fluid pressure, ring-shaped magnets 13A and 13B are fitted with small-diameter portions 11a formed at end portions of a valve element 11 and is fixed by press fitting and engaging caps 14A and 14B forming faces to be in contact with pistons 14A and 14B at the valve element ends. A housing chamber 30 is formed outside a valve hole 10a in a valve body 10 and in a position close to the magnets, magnetometric sensors 31A and 31B are housed in the housing chamber 30, and a cover 35 is mounted to the housing chamber 30.

Abstract: A pilot-type solenoid valve capable of driving a valve member by increasing a pilot fluid pressure from a pilot valve and reliably switching valve member. The pilot-type solenoid valve includes a main valve portion having a valve member capable of sliding in a valve hole to which ports P, A, B, EA and EB in a valve body are opened, a pilot driving mechanism for applying a pilot fluid pressure to a pushing member which pushes one end of the valve member, and a returning mechanism for applying a returning force to the valve member. The pushing member includes a first piston for applying the pilot fluid pressure, and a second piston which is pushed by the first piston and which pushes the valve member. A shaft of the first piston passes through a partition wall in a sealing manner and abuts against the second piston. The shaft is provided therein with a guide hole for guiding the pilot fluid pressure to a pressure chamber of the second piston.

Abstract: Disclosed are 5,11-Dihydrodibenzo[b,e][1,4]oxazepine derivatives such as (R)-(+)-5,11-dihydro-5-[1-(4-methoxyphenethyl)-2-pyrrolidinylmethyl]dibenz o[b,e][1,4]oxazepine and (R)-(+)-5,11-dihydro-5-[1-(4-fluorophenethyl)-2-pyrrolidinylmethyl]dibenzo [b,e][1,4]oxazepine, stereoisomers thereof, pharmacologically acceptable salts thereof, or hydrates thereof and a phramaceutical composition conating the 5,11-Dihydrodibenzo[b,e][1,4]oxazepine derivatives. The derivatives have an excellent activity of improving a digestive tract moving function and are free of side effect.