Patents by Inventor Keiji Naruse

Keiji Naruse has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150315242
    Abstract: Provide are a peptide gel with practically sufficient mechanical strength and a self-assembling peptide capable of forming the peptide gel. The self-assembling peptide is formed of the following amino acid sequence: a1b1c1b2a2b3db4a3b5c2b6a4 where: a1 to a4 each represent a basic amino acid residue; b1 to b6 each represent an uncharged polar amino acid residue and/or a hydrophobic amino acid residue, provided that at least five thereof each represent a hydrophobic amino acid residue; c1 and c2 each represent an acidic amino acid residue; and d represents a hydrophobic amino acid residue.
    Type: Application
    Filed: July 14, 2015
    Publication date: November 5, 2015
    Inventors: Yusuke Nagai, Hidenori Yokoi, Koji Uesugi, Keiji Naruse, Shuguang Zhang
  • Publication number: 20150125611
    Abstract: Provide are a peptide gel with practically sufficient mechanical strength and a self-assembling peptide capable of forming the peptide gel. The self-assembling peptide is formed of the following amino acid sequence: a1b1c1b2a2b3db4a3b5c2b6a4 where: a1 to a4 each represent a basic amino acid residue; b1 to b6 each represent an uncharged polar amino acid residue and/or a hydrophobic amino acid residue, provided that at least five thereof each represent a hydrophobic amino acid residue; c1 and c2 each represent an acidic amino acid residue; and d represents a hydrophobic amino acid residue.
    Type: Application
    Filed: January 12, 2015
    Publication date: May 7, 2015
    Applicants: Menicon Co., Ltd., National University Corporation Okayama University
    Inventors: Yusuke NAGAI, Hidenori Yokoi, Koji Uesugi, Keiji Naruse
  • Patent number: 8951974
    Abstract: Provide are a peptide gel with practically sufficient mechanical strength and a self-assembling peptide capable of forming the peptide gel. The self-assembling peptide is formed of the following amino acid sequence: a1b1c1b2a2b3 db4a3b5c2b6a4 where: a1 to a4 each represent a basic amino acid residue; b1 to b6 each represent an uncharged polar amino acid residue and/or a hydrophobic amino acid residue, provided that at least five thereof each represent a hydrophobic amino acid residue; c1 and c2 each represent an acidic amino acid residue; and d represents a hydrophobic amino acid residue.
    Type: Grant
    Filed: March 26, 2014
    Date of Patent: February 10, 2015
    Assignees: Menicon Co., Ltd., National University Corporation Okayama University
    Inventors: Yusuke Nagai, Hidenori Yokoi, Koji Uesugi, Keiji Naruse
  • Publication number: 20140286888
    Abstract: Provide are a peptide gel with practically sufficient mechanical strength and a self-assembling peptide capable of forming the peptide gel. The self-assembling peptide is formed of the following amino acid sequence: a1b1c1b2a2b3 db4a3b5c2b6a4 where: a1 to a4 each represent a basic amino acid residue; b1 to b6 each represent an uncharged polar amino acid residue and/or a hydrophobic amino acid residue, provided that at least five thereof each represent a hydrophobic amino acid residue; c1 and c2 each represent an acidic amino acid residue; and d represents a hydrophobic amino acid residue.
    Type: Application
    Filed: March 26, 2014
    Publication date: September 25, 2014
    Applicants: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY, MENICON CO., LTD.
    Inventors: Yusuke NAGAI, Hidenori Yokoi, Koji Uesugi, Keiji Naruse
  • Patent number: 8815078
    Abstract: Disclosed are a pH or concentration measuring device and a pH or concentration measuring method which enable measurement in the shortest possible time even in an object to be measured having low buffer capacity.
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: August 26, 2014
    Assignee: National University Corporation Okayama University
    Inventors: Akira Yamada, Michihiro Nakamura, Satoshi Mohri, Keiji Naruse
  • Publication number: 20140161753
    Abstract: Provide are a peptide gel with practically sufficient mechanical strength and a self-assembling peptide capable of forming the peptide gel. The self-assembling peptide is formed of the following amino acid sequence: a1b1c1b2a2b3db4a3b5c2b6a4 where: a1 to a4 each represent a basic amino acid residue; b1 to b6 each represent an uncharged polar amino acid residue and/or a hydrophobic amino acid residue, provided that at least five thereof each represent a hydrophobic amino acid residue; c1 and c2 each represent an acidic amino acid residue; and d represents a hydrophobic amino acid residue.
    Type: Application
    Filed: June 27, 2013
    Publication date: June 12, 2014
    Inventors: YUSUKE NAGAI, HIDENORI YOKOI, KOJI UESUGI, KEIJI NARUSE, SHUGUANG ZHANG
  • Patent number: 8729032
    Abstract: Provide are a peptide gel with practically sufficient mechanical strength and a self-assembling peptide capable of forming the peptide gel. The self-assembling peptide is formed of the following amino acid sequence: a1b1c1b2a2b3db4a3b5c2b6a4 where: a1 to a4 each represent a basic amino acid residue; b1 to b6 each represent an uncharged polar amino acid residue and/or a hydrophobic amino acid residue, provided that at least five thereof each represent a hydrophobic amino acid residue; c1 and c2 each represent an acidic amino acid residue; and d represents a hydrophobic amino acid residue.
    Type: Grant
    Filed: February 12, 2010
    Date of Patent: May 20, 2014
    Assignees: Menicon Co., Ltd., National University Corporation Okayama University
    Inventors: Yusuke Nagai, Hidenori Yokoi, Koji Uesugi, Keiji Naruse
  • Publication number: 20140113365
    Abstract: A cell culture vessel supplies cells close to the center of gel and deeper down to the bottom with sufficient nutrients for attaining an enhanced survival rate of the cultivated cells. The cell culturing vessel comprises a culture tray capable of holding a liquid culture medium and a cell mixture container fixed to inner walls of the culture tray for retaining the cell mixture. Once the culture tray is filled with the liquid culture medium, the cell mixture retained in the cell mixture container has its opposite outer parts exposed to the liquid culture medium.
    Type: Application
    Filed: April 26, 2012
    Publication date: April 24, 2014
    Applicants: NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY, MENICON CO., LTD.
    Inventors: Yusuke Nagai, Keiji Naruse, Ken Takahashi, Eijiro Tokuyama
  • Publication number: 20120145563
    Abstract: Disclosed are a pH or concentration measuring device and a pH or concentration measuring method which enable measurement in the shortest possible time even in an object to be measured having low buffer capacity.
    Type: Application
    Filed: August 24, 2010
    Publication date: June 14, 2012
    Applicant: National University Corporation Okayama University
    Inventors: Akira Yamada, Michihiro Nakamura, Satoshi Mohri, Keiji Naruse
  • Publication number: 20120058066
    Abstract: Provide are a peptide gel with practically sufficient mechanical strength and a self-assembling peptide capable of forming the peptide gel. The self-assembling peptide is formed of the following amino acid sequence: a1b1c1b2a2b3db4a3b5c2b6a4 where: a1 to a4 each represent a basic amino acid residue; b1 to b6 each represent an uncharged polar amino acid residue and/or a hydrophobic amino acid residue, provided that at least five thereof each represent a hydrophobic amino acid residue; c1 and c2 each represent an acidic amino acid residue; and d represents a hydrophobic amino acid residue.
    Type: Application
    Filed: February 12, 2010
    Publication date: March 8, 2012
    Applicants: NATIONAL UNIV. CORPORATION OKAYAMA UNIV., MENICON CO., LTD.
    Inventors: Yusuke Nagai, Hidenori Yokoi, Koji Uesugi, Keiji Naruse
  • Publication number: 20070178584
    Abstract: A culture device to apply uniform stress to cells is proposed. A culture device is formed in a rectangular box shape from a deformable material, comprising a bottom membrane and side walls upstanding from the entire periphery of said bottom membrane, wherein an engaging member is formed in opposing side walls on a line extended from a peripheral edge of said bottom membrane. By providing the latching member in the culture membrane so as to latch the cells to the latching member, the slippage between the bottom membrane and sample cells is forestalled upon the extension of the culture membrane.
    Type: Application
    Filed: March 9, 2005
    Publication date: August 2, 2007
    Applicant: NAGOYA INDUSTRIAL SCIENCE RESEARCH INSTITUTE
    Inventors: Keiji Naruse, Norio Ishida
  • Patent number: 6653089
    Abstract: The present invention is directed, in certain embodiments, to improved, small scale systems and methods able to selectively treat parts of a single cell, including, in certain embodiments, portions of a main body portion of a single cell, and able, in certain embodiments, to establish long-term gradients of active substances within subcellular regions of a single cell. The present invention provides, in some embodiments, techniques for selectively contacting a portion of the surface of a biological cell with a fluid or fluid component carrying a particular potential for a biophysical or biochemical interaction with the cell, and simultaneously contacting a different portion of the surface of the cell with another fluid or fluid component having a different potential for the biophysical or biochemical interaction with the cell.
    Type: Grant
    Filed: September 18, 2001
    Date of Patent: November 25, 2003
    Assignees: President and Fellows of Harvard College, Children's Medical Center Corporation
    Inventors: Shuichi Takayama, Emanuele Ostuni, Philip LeDuc, Keiji Naruse, Donald E. Ingber, George M. Whitesides
  • Publication number: 20020146822
    Abstract: The present invention is directed, in certain embodiments, to improved, small scale systems and methods able to selectively treat parts of a single cell, including, in certain embodiments, portions of a main body portion of a single cell, and able, in certain embodiments, to establish long-term gradients of active substances within subcellular regions of a single cell. The present invention provides, in some embodiments, techniques for selectively contacting a portion of the surface of a biological cell with a fluid or fluid component carrying a particular potential for a biophysical or biochemical interaction with the cell, and simultaneously contacting a different portion of the surface of the cell with another fluid or fluid component having a different potential for the biophysical or biochemical interaction with the cell.
    Type: Application
    Filed: September 18, 2001
    Publication date: October 10, 2002
    Inventors: Shuichi Takayama, Emanuele Ostuni, Philip LeDuc, Keiji Naruse, Donald E. Ingber, George M. Whitesides