Patents by Inventor Keiji Nishida

Keiji Nishida has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11111871
    Abstract: Provided is an ignition control section and an injection control section. When partial compression ignition combustion is carried out, the ignition control section causes an ignition plug to carry out: main ignition in which a spark is generated in a late period of a compression stroke or an initial period of an expansion stroke to initiate SI combustion; and preceding ignition in which the spark is generated at earlier timing than the main ignition. Also, when the partial compression ignition combustion is carried out, the injection control section causes an injector to inject fuel at such timing that the fuel exists in a cylinder at an earlier time point than the preceding ignition. Ignition timing of the preceding ignition is set to be more advanced when an in-cylinder temperature specified by an in-cylinder temperature specification section is high than when the in-cylinder temperature is low.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: September 7, 2021
    Assignee: Mazda Motor Corporation
    Inventors: Kota Matsumoto, Tomonori Urushihara, Keiji Maruyama, Masanari Sueoka, Ryohei Ono, Yuji Harada, Toru Miyamoto, Atsushi Inoue, Tatsuhiro Tokunaga, Takuya Ohura, Yusuke Kawai, Tomohiro Nishida, Keita Arai, Yodai Yamaguchi
  • Patent number: 11105255
    Abstract: The invention is provided with an ignition control section and an injection control section. When partial compression ignition combustion is carried out, the ignition control section causes an ignition plug to carry out: main ignition in which a spark is generated in a late period of a compression stroke or an initial period of an expansion stroke to initiate SI combustion; and preceding ignition in which the spark is generated at earlier timing than the main ignition. Also, when the partial compression ignition combustion is carried out, the injection control section causes an injector to inject fuel at such timing that the fuel exists in a cylinder at an earlier time point than the preceding ignition. Ignition timing of the preceding ignition is set to be more retarded when fuel concentration specified by a fuel concentration specification section is low than when the fuel concentration is high.
    Type: Grant
    Filed: April 17, 2019
    Date of Patent: August 31, 2021
    Assignee: Mazda Motor Corporation
    Inventors: Kota Matsumoto, Tomonori Urushihara, Keiji Maruyama, Masanari Sueoka, Ryohei Ono, Yuji Harada, Toru Miyamoto, Atsushi Inoue, Tatsuhiro Tokunaga, Takuya Ohura, Yusuke Kawai, Tomohiro Nishida, Keita Arai, Yodai Yamaguchi
  • Patent number: 11041169
    Abstract: The present invention provides a method for modifying a targeted site of a double-stranded DNA in a cell, the method including a step of bringing a complex in which a nucleic acid sequence-recognizing module that specifically binds to a selected target nucleotide sequence in a double-stranded DNA and a nucleic acid base converting enzyme or DNA glycosylase are linked, and a donor DNA containing an insertion sequence into contact with said double-stranded DNA, to substitute the targeted site with the insertion sequence, or insert the insertion sequence into said targeted site, without cleaving at least one strand of said double-stranded DNA in the targeted site.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: June 22, 2021
    Assignee: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY
    Inventor: Keiji Nishida
  • Publication number: 20210171935
    Abstract: The present invention provides a method of modifying a targeted site of a double stranded DNA, including a step of contacting a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a selected double stranded DNA and DNA glycosylase with sufficiently low reactivity with a DNA having an unrelaxed double helix structure (unrelaxed DNA) are bonded, with the double stranded DNA, to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into the targeted site, without cleaving at least one strand of the double stranded DNA in the targeted site.
    Type: Application
    Filed: February 12, 2021
    Publication date: June 10, 2021
    Applicant: National University Corporation Kobe University
    Inventors: Keiji NISHIDA, Akihiko KONDO
  • Patent number: 11001856
    Abstract: The present invention provides a method for modifying a targeted site of a double-stranded DNA in a cell, the method including a step of bringing a complex in which a nucleic acid sequence-recognizing module that specifically binds to a selected target nucleotide sequence in a double-stranded DNA and a nucleic acid base converting enzyme or DNA glycosylase are linked, and a donor DNA containing an insertion sequence into contact with said double-stranded DNA, to substitute the targeted site with the insertion sequence, or insert the insertion sequence into said targeted site, without cleaving at least one strand of said double-stranded DNA in the targeted site.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: May 11, 2021
    Assignee: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY
    Inventor: Keiji Nishida
  • Patent number: 10920215
    Abstract: The present invention provides a method of modifying a targeted site of a double stranded DNA, including a step of contacting a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a selected double stranded DNA and DNA glycosylase with sufficiently low reactivity with a DNA having an unrelaxed double helix structure (unrelaxed DNA) are bonded, with the double stranded DNA, to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into the targeted site, without cleaving at least one strand of the double stranded DNA in the targeted site.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: February 16, 2021
    Assignee: National University Corporation Kobe University
    Inventors: Keiji Nishida, Akihiko Kondo
  • Publication number: 20210024906
    Abstract: The present invention provides a complex containing a nucleic acid sequence-recognizing module and a proteolysis tag, wherein the module is linked to the proteolysis tag, the module specifically binds to a target nucleotide sequence in a double stranded DNA, and the tag consists of (i) a peptide containing 3 hydrophobic amino acid residues at the C-terminal, or (ii) a peptide containing 3 amino acid residues at the C-terminal m wherein at least a part of the amino acid residues is substituted by serine.
    Type: Application
    Filed: November 21, 2018
    Publication date: January 28, 2021
    Applicant: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY
    Inventor: Keiji NISHIDA
  • Publication number: 20200377910
    Abstract: The present invention provides a method of modifying a targeted site of a double-stranded DNA, comprising a step of introducing a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a double-stranded DNA and PmCDA1 are bonded, into a cell containing the double-stranded DNA, and culturing the cell at a low temperature at least temporarily to convert the targeted site, i.e., the target nucleotide sequence and nucleotides in the vicinity thereof, to other nucleotides, or delete the targeted site, or insert nucleotide into the site.
    Type: Application
    Filed: April 21, 2017
    Publication date: December 3, 2020
    Applicant: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY
    Inventors: Keiji NISHIDA, Akihiko KONDO, Takayuki ARAZOE, Zenpei SHIMATANI
  • Patent number: 10767173
    Abstract: The invention provides a method of modifying a targeted site of gram-positive bacterium of a double stranded DNA. The method includes contacting the double-stranded DNA with a complex of a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a given double stranded DNA and a nucleic acid base converting enzyme to convert, delete, or insert one or more nucleotides in the targeted site without cleaving at least one strand of the double stranded DNA in the targeted site, by introducing the nucleic acid encoding the complex into the gram-positive bacterium. The invention also provide a nucleic acid-modifying enzyme complex of a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a double stranded DNA of a gram-positive bacterium and a nucleic acid base converting enzyme bonded to each other, which complex is used for the method.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: September 8, 2020
    Assignees: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY, NIPPON SHOKUBAI CO., LTD.
    Inventors: Masaharu Mukoyama, Eita Ichige, Keiji Nishida, Akihiko Kondo
  • Publication number: 20200270631
    Abstract: The present invention provides a method for modifying a targeted site of a double-stranded DNA in a cell, the method including a step of bringing a complex in which a nucleic acid sequence-recognizing module that specifically binds to a selected target nucleotide sequence in a double-stranded DNA and a nucleic acid base converting enzyme or DNA glycosylase are linked, and a donor DNA containing an insertion sequence into contact with said double-stranded DNA, to substitute the targeted site with the insertion sequence, or insert the insertion sequence into said targeted site, without cleaving at least one strand of said double-stranded DNA in the targeted site.
    Type: Application
    Filed: March 26, 2019
    Publication date: August 27, 2020
    Applicant: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY
    Inventor: Keiji NISHIDA
  • Publication number: 20200248174
    Abstract: The invention provides a method of modifying a targeted site of a double stranded DNA, including a step of contacting a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a selected double stranded DNA and a nucleic acid base converting enzyme are linked, with the double stranded DNA, to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into the targeted site, without cleaving at least one strand of the double stranded DNA in the targeted site.
    Type: Application
    Filed: April 2, 2020
    Publication date: August 6, 2020
    Inventors: Keiji Nishida, Akihiko Kondo, Satomi Kojima
  • Publication number: 20200208138
    Abstract: The invention provides a method of modifying a targeted site of a double stranded DNA, including a step of contacting a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a selected double stranded DNA and a nucleic acid base converting enzyme are linked, with the double stranded DNA, to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into the targeted site, without cleaving at least one strand of the double stranded DNA in the targeted site.
    Type: Application
    Filed: February 14, 2020
    Publication date: July 2, 2020
    Inventors: Keiji Nishida, Akihiko Kondo, Satomi Kojima
  • Patent number: 10655123
    Abstract: The invention provides a method of modifying a targeted site of a double stranded DNA, including a step of contacting a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a selected double stranded DNA and a nucleic acid base converting enzyme are linked, with the double stranded DNA, to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into the targeted site, without cleaving at least one strand of the double stranded DNA in the targeted site.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: May 19, 2020
    Assignee: National University Corporation Kobe University
    Inventors: Keiji Nishida, Akihiko Kondo, Satomi Kojima
  • Publication number: 20200010856
    Abstract: Provided is a method for altering a targeted site of a DNA in a cell, including a step of stimulating the cell with a factor inducing a DNA modifying enzyme endogenous to the cell, and bringing a complex of a nucleic acid sequence-recognizing module specifically binding to a target nucleotide sequence in a given DNA and a DNA modifying enzyme-binding module bonded to each other into contact with the DNA to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into the targeted site.
    Type: Application
    Filed: March 20, 2018
    Publication date: January 9, 2020
    Applicant: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY
    Inventors: Keiji NISHIDA, Akihiko KONDO, Takayuki ARAZOE, Shin YOSHIOKA
  • Publication number: 20190203198
    Abstract: The invention provides a method of modifying a targeted site of gram-positive bacterium of a double stranded DNA. The method includes contacting the double-stranded DNA with a complex of a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a given double stranded DNA and a nucleic acid base converting enzyme to convert, delete, or insert one or more nucleotides in the targeted site without cleaving at least one strand of the double stranded DNA in the targeted site, by introducing the nucleic acid encoding the complex into the gram-positive bacterium. The invention also provide a nucleic acid-modifying enzyme complex of a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a double stranded DNA of a gram-positive bacterium and a nucleic acid base converting enzyme bonded to each other, which complex is used for the method.
    Type: Application
    Filed: September 9, 2016
    Publication date: July 4, 2019
    Applicants: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY, NIPPON SHOKUBAI CO., LTD.
    Inventors: Masaharu MUKOYAMA, Eita ICHIGE, Keiji NISHIDA, Akihiko KONDO
  • Publication number: 20190085342
    Abstract: The present invention provides a method of modifying a targeted site of a double stranded DNA of a monocot cell, comprising a step of contacting a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in the given double stranded DNA and a nucleic acid base converting enzyme are bonded, with said double stranded DNA, to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into said targeted site, without cleaving at least one strand of said double stranded DNA in the targeted site, wherein the double stranded DNA is contacted with the complex by introducing a nucleic acid encoding the complex into the monocot cell.
    Type: Application
    Filed: November 25, 2016
    Publication date: March 21, 2019
    Applicant: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY
    Inventors: Keiji NISHIDA, Zenpei SHIMATANI, Akihiko KONDO
  • Publication number: 20190024098
    Abstract: The present invention provides a method of modifying a targeted site of a double stranded DNA in a host cell, the method including introducing (a) a DNA encoding a crRNA containing a sequence complementary to a target strand of a target nucleotide sequence in the given double stranded DNA, and (b) a DNA encoding a protein group constituting Cascade and a nucleic acid base converting enzyme, in which the nucleic acid base converting enzyme is constituted in a form capable of forming a complex with any protein in the protein group, into the host cell to convert one or more nucleotides in the targeted site to other one or more nucleotides, or delete one or more nucleotides, or insert one or more nucleotides into said targeted site, without cleaving the double stranded DNA in the targeted site.
    Type: Application
    Filed: September 8, 2016
    Publication date: January 24, 2019
    Applicant: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY
    Inventors: Keiji NISHIDA, Satomi KOJIMA, Akihiko KONDO
  • Publication number: 20170352085
    Abstract: A person in charge of a company, a user of a semiconductor manufacturing apparatus, uses an information terminal to log in via the Internet to a server of a part selling company selling, in an electronic shop, parts of the semiconductor manufacturing apparatus, and specifies a predetermined keyword for a part search. The person in charge specifies a sell-candidate part displayed as a search result, and requests detailed information to be displayed. A part information page generating unit of the server generates a web page describing the specified part's detailed information. The part information page generating unit describes in the web page at least a quantity of specified part's stocks in a nearby local warehouse to the user company. The part information page generating unit differentiates items to be described in a web page in accordance with a hierarchy of a person in charge of a user company.
    Type: Application
    Filed: May 16, 2017
    Publication date: December 7, 2017
    Inventors: Tadashi FUKUDA, Keiji NISHIDA
  • Publication number: 20170321210
    Abstract: The present invention provides a method of modifying a targeted site of a double stranded DNA, including a step of contacting a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a selected double stranded DNA and DNA glycosylase with sufficiently low reactivity with a DNA having an unrelaxed double helix structure (unrelaxed DNA) are bonded, with the double stranded DNA, to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into the targeted site, without cleaving at least one strand of the double stranded DNA in the targeted site.
    Type: Application
    Filed: November 2, 2015
    Publication date: November 9, 2017
    Applicant: National University Corporation Kobe University
    Inventors: Keiji NISHIDA, Akihiko KONDO
  • Publication number: 20170073670
    Abstract: The present invention provides a method of modifying a targeted site of a double stranded DNA, including a step of contacting a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a selected double stranded DNA and a nucleic acid base converting enzyme are bonded, with the double stranded DNA, to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into the targeted site, without cleaving at least one chain of the double stranded DNA in the targeted site.
    Type: Application
    Filed: March 4, 2015
    Publication date: March 16, 2017
    Applicant: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY
    Inventors: Keiji NISHIDA, Akihiko KONDO, Satomi KOJIMA