Abstract: Provided are crystals of 1-((2-(3,6-diazabicyclo[3.1.

Abstract: The invention is to simplify operations performed when imaging an electron diffraction pattern by using a transmission electron microscope. As a solution to the problem, a transmission electron microscope includes a detector to which an electron diffraction pattern is projected, a mask for zero-order wave configured to be inserted into and pulled out from between a sample and the detector, and a current detector configured to be inserted into and pulled out from a detection region of the zero-order waves in a state where the mask is inserted. An amount of current of electron beams emitted to the mask is measured in real time, and the measurement result is automatically reflected in settings of imaging conditions of an imaging camera provided in the transmission electron microscope.

Abstract: Provided is a transmission electron microscope capable of obtaining a hollow-cone dark-field image and visually displaying irradiation conditions thereof. The transmission electron microscope is provided with an irradiation unit for irradiating a specimen with an electron beam, an objective lens for causing the electron beam transmitted through the specimen to form an image, beam deflectors for deflecting the electron beam, said beam deflectors being positioned higher than a position where the specimen is to be placed, an objective movable aperture for passing only a portion of the electron beam transmitted through the specimen, and a deflection coil control unit.

Abstract: A therapeutic agent for treating at least one disease selected from the group consisting of inflammatory diseases, autoimmune diseases, fibrotic diseases, and cancer diseases, comprising: at least one selected from the group consisting of a compound represented by the following general formula (1) and pharmacologically acceptable salts thereof as an active ingredient. [In the formula (1), R1 and R2 may be the same or different and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a carboxy group, a cyano group, an optionally substituted C1-6 alkyl group et al.; R3 represents a hydrogen atom; R4 represents an optionally substituted 4- to 10-membered monocyclic heterocyclic group containing 1 to 4 heteroatoms selected from an oxygen atom, a nitrogen atom, and a sulfur atom; X represents a group represented by the following formula: —CH2—, —CH2—CH2—, —CH2—CH2—CH2—, or —CH2—O—CH2—; and Z represents a hydrogen atom or a hydroxyl group.

Abstract: Provided are crystals of 1-((2-(3,6-diazabicyclo[3.1.

Abstract: A compound represented by the general formula (1) below or a pharmacologically acceptable salt thereof: [In the formula (1), R1 and R2 may be the same or different and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a carboxy group, a cyano group, an optionally substituted C1-6 alkyl group et al.; R3 represents a hydrogen atom; R4 represents an optionally substituted 4- to 10-membered monocyclic heterocyclic group containing 1 to 4 heteroatoms selected from an oxygen atom, a nitrogen atom, and a sulfur atom; X represents a group represented by the following formula: —CH2—, —CH2—CH2—, —CH2—CH2—CH2—, or —CH2—O—CH2—; and Z represents a hydrogen atom or a hydroxyl group].

Abstract: An electron microscope for observation by illuminating an electron beam on a specimen, includes: an edge element disposed in a diffraction plane where a direct beam not diffracted by but transmitted through the specimen converges or a plane equivalent to the diffraction plane; and a control unit for controlling the electron beam or the edge element. The edge element includes a blocking portion for blocking the electron beam, and an aperture for allowing the passage of the electron beam. The aperture is defined by an edge of the blocking portion in a manner that the edge surrounds a convergence point of the direct beam in the diffraction plane. The control unit varies contrast of an observation image by shifting, relative to the edge, the convergence point of the direct beam along the edge while maintaining a predetermined distance between the convergence point of the direct beam and the edge.

Abstract: A compound represented by the general formula (1) below or a pharmacologically acceptable salt thereof: [In the formula (1), R1 and R2 may be the same or different and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a carboxy group, a cyano group, an optionally substituted C1-6 alkyl group et al.; R3 represents a hydrogen atom; R4 represents an optionally substituted 4- to 10-membered monocyclic heterocyclic group containing 1 to 4 heteroatoms selected from an oxygen atom, a nitrogen atom, and a sulfur atom; X represents a group represented by the following formula: —CH2—, —CH2—CH2—, —CH2—CH2—CH2—, or —CH2—O—CH2—; and Z represents a hydrogen atom or a hydroxyl group.

Abstract: An electron microscope for observation by illuminating an electron beam on a specimen, includes: an edge element disposed in a diffraction plane where a direct beam not diffracted by but transmitted through the specimen converges or a plane equivalent to the diffraction plane; and a control unit for controlling the electron beam or the edge element. The edge element includes a blocking portion for blocking the electron beam, and an aperture for allowing the passage of the electron beam. The aperture is defined by an edge of the blocking portion in a manner that the edge surrounds a convergence point of the direct beam in the diffraction plane. The control unit varies contrast of an observation image by shifting, relative to the edge, the convergence point of the direct beam along the edge while maintaining a predetermined distance between the convergence point of the direct beam and the edge.

Abstract: A macrolide compound represented by the formula (I) effective against erythromycin resistant bacteria (for example, resistant pneumococci, streptococci and mycoplasmas).

Abstract: The present invention has an object to provide a cold cathode field-emission electron gun with low aberration, to thereby provide a high-brightness electron gun even in the case of a large current. The present invention provides a field-emission electron gun which extracts an electron beam from a cathode and converges the extracted electron beam, the field-emission electron gun including: a magnetic field lens which is provided such that the cathode is disposed inside of a magnetic field of the lens; and an extraction electrode for extracting electrons from the cathode, the extraction electrode being formed into a cylindrical shape without an aperture structure. The present invention can provide an electron gun having a function of converging an electron beam using a magnetic field, the electron gun which is capable of reducing an incidental electrostatic lens action and has small aberration and high brightness.

Abstract: A macrolide compound represented by the formula (I) effective against erythromycin resistant bacteria (for example, resistant pneumococci, streptococci and mycoplasmas).

Abstract: The present invention has an object to provide a cold cathode field-emission electron gun with low aberration, to thereby provide a high-brightness electron gun even in the case of a large current. The present invention provides a field-emission electron gun which extracts an electron beam from a cathode and converges the extracted electron beam, the field-emission electron gun including: a magnetic field lens which is provided such that the cathode is disposed inside of a magnetic field of the lens; and an extraction electrode for extracting electrons from the cathode, the extraction electrode being formed into a cylindrical shape without an aperture structure. The present invention can provide an electron gun having a function of converging an electron beam using a magnetic field, the electron gun which is capable of reducing an incidental electrostatic lens action and has small aberration and high brightness.

Abstract: The present invention provides an electron beam instrument in which variation of the trajectory of the electron beams can be suppressed even when the voltage applied to the first extractor electrode is controlled in order to stabilize the emission current amount of the electron beams. The electron beam instrument has a cold cathode field emission electron gun. The cold cathode field emission electron gun has a cold cathode, a first extractor electrode and a second extractor electrode. Distance between the cold cathode and the first extractor electrode is set to be shorter than distance between the first extractor electrode and the second extractor electrode. Voltage applied to the first extractor electrode is increased when current amount of the electron beams emitted from the cold cathode is attenuated.

Abstract: A method for objectively assessing and monitoring the relative health and homeostatic balance of a group of animals or the individual animals in the group as a basis for animal management decisions is provided. The objective assessment and monitoring method quantitatively determines the upper limit of normal for &agr;1-acid glycoprotein values in a selected body fluid of a selected species of animals. The &agr;1-acid glycoprotein levels of the animals to be evaluated are quantitatively determined and compared with the normal &agr;1-acid glycoprotein upper limit to identify animals whose immune systems or health has been compromised by stress or disease to provide a basis for animal management decisions to promote and maintain the optimum health and well being of the group.

Abstract: A biologically active, stable protein with a molecular weight of 20,000 to 30,000 and an isoelectric point of 8.0-10.0 is produced from the culture fluid of Streptococcus pyogenes and purified. The purified biologically active protein produces lymphocyte proliferation, provides protection against bacterial and viral infection and restricts minor metastasis.

Abstract: A roller bottle handling system includes a culture rack storage station for storing a plurality of culture racks each for accommodating a plurality of roller bottles each filled with a culture medium and cells, and a mass-handling facility for extracting completed cultures from roller bottles and replacing a culture medium in the roller bottles with a new culture medium. The roller bottle handling system further includes an unloading station for taking out roller bottles from culture racks delivered from the culture rack storage station and delivering the roller bottles to the mass-handling facility, and a loading station for charging roller bottles filled with a culture medium and cells into culture racks. Automatic guided vehicles or overhead traveling cranes are movable to deliver culture racks, one at a time, between the culture rack storage station and the unloading and loading stations.

Abstract: A rare-earth metal series alloy for storage of hydrogen is represented by a general formula of Rem.sub.1 Ni.sub.w Al.sub.x Fe.sub.y M.sub.z as an atomic ratio (wherein Rem is at least one rare earth element such as Mischmetal, M is at least one of Cu, Nb, Si and Zr, and 2.5<w<5.5, 0<x<2.0, 0<y<2.0, 0<z<2.0 and 4.0.ltoreq.w+x+y+z.ltoreq.6.0). Further, the alloy is coated with a film of at least one of Pd, Cu and Ni having a thickness of 100-1000 .ANG..

Abstract: A zirconium alloy having a plateau region of equilibrium hydrogen dissociation pressure and a small hysteresis, whose hydrogen dissociation pressure is in a range of 0.6 to 3 atm at 20.degree. C., 1 to 5 atm at 40.degree. C., and 1 to 17 atm at 80.degree. C., the activation of which can be effected according to a single procedure of vacuum evacuation at room temperature and pressurization under a hydrogen pressure of 30 atm at room temperature, and which is comparable or superior in the rates of hydrogen absorption and release, the maximum hydrogen absorbing capacity and effective hydrogen releasing capacity to conventional zirconium alloys. A hydrogen absorbing and releasing material comprising an alloy as mentioned above and thin films of one element selected from Pd, Cu, and Ni, which allows only hydrogen to permeate, and covering the surfaces of particles of the alloy.

Abstract: The present invention provides a method for the preparation of a specific immune serum by immunizing IAP in animals other than humans and absorbing the thus obtained serum with normal human serum.