Patent number: 6673804
Abstract: A compound of the formula (I) or a pharmacologically acceptable salt, ester or other derivative thereof:
R1 is H or NHOH. R2 is H, optionally substituted alkyl, cycloalkyl or a group —AR6.
A is an alkylene which may be optionally interrupted by O, —S(O)m— or —N(R9). R6 is a group (II), (III), (IV)
X is O, S, —N(R10)—, —C(R11)(R12)—. Y is O, CO, —S(O)n—, —N(R10)—, —C(R11)(R12)—. Each of R7 and R8 is H, alkyl, COOH, optionally substituted alkyl, etc. Each of R9, R10, R11, and R12 is H, alkyl, etc. Each of m and n is 0 to 2. R3 is H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl. R4 is optionally substituted (hetero)arylene. R5 is optionally substituted alkyl, optionally substituted (hetero)aryl. These compounds have matrixmetalloproteinase—13 inhibitory activity and aglycanase inhibitory activity.
Type:
Grant
Filed:
October 2, 2000
Date of Patent:
January 6, 2004
Assignee:
Sankyo Company, Limited
Inventors:
Tomio Kimura, Shoujiro Miyazaki, Keiji Ueda, Kazuhiko Tanzawa, Shigeru Ushiyama, Wataru Takasaki