Abstract: The present invention relates to a nucleic acid conjugate represented by the following formula 1: wherein X is an oligonucleotide, L1 and L2 are each independently sugar ligand, and S1, S2 and S3 are each independently a linker.

Abstract: The present invention provides a nucleic acid conjugate in which a sugar chain ligand is bonded to an oligonucleotide via a linker, the sugar chain ligand having O-bonded mannose at its non-reducing end.

Abstract: The present invention relates to a nucleic acid conjugate represented by the following formula 1: wherein X is an oligonucleotide, L1 and L2 are each independently sugar ligand, and S1, S2 and S3 are each independently a linker.

Abstract: The present invention provides a nucleic acid conjugate comprising: a double-stranded nucleic acid consisting of a sense strand and an antisense strand and comprising a duplex region of at least 11 base pairs; and a ligand part, wherein an oligonucleotide with a strand length of 17 to 30 nucleotides in the antisense strand is complementary to a target ?2GPI mRNA sequence, and the 3? end or 5? end of the sense strand has a ligand part represented by following formula (I), formula (II), formula (III), formula (IV) or formula (V).

Abstract: The invention provides a method of activating PPAR ? and a method of treating or preventing a disease associated with PPAR ? by administering a tricyclic compound having a PPAR ? agonist activity, which is represented by the formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R4-R9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R10 and R11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:

Abstract: The invention provides a method of activating PPAR ? and a method of treating or preventing a disease associated with PPAR ? by administering a tricyclic compound having a PPAR ? agonist activity, which is represented by the formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R4-R9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R10 and R11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:

Abstract: The invention provides a method of activating PPAR ? and a method of treating or preventing a disease associated with PPAR ? by administering a tricyclic compound having a PPAR ? agonist activity, which is represented by the formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R4-R9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R10 and R11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:

Abstract: Provided is a tricyclic compound having a PPAR ? agonist activity, which is represented by the general formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R4-R9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R10 and R11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:

Abstract: Provided is a tricyclic compound having a PPAR ? agonist activity, which is represented by the general formula (I) wherein Z represents a single bond or the like, Y represents a hydrogen atom, lower alkyl optionally having substituent(s) or the like, X represents a hydrogen atom or the like, A represents aryl or the like, B and C are the same or different and each represents an aromatic carbocycle or the like, R4-R9 are the same or different and each represents hydrogen or the like, V represents a single bond or the like, R10 and R11 are the same or different and each represents hydrogen or the like, or a pharmaceutically acceptable salt thereof or the like:

Abstract: Either a first memory card (13) for storing subscriber's information indispensable for communication, such as information on contract with a communication carrier or information to identify the user as a subscriber or a second memory card (15) for mainly storing application programs is selectively connected to a mobile radio apparatus. When the second memory card is installed, a main control unit (16) transfers the subscriber's information stored in the first memory card to the second memory card. Based on the subscriber's information, the main control unit receives the incoming call signal from a base station and informs notice of an incoming call. To speak by telephone, the second memory card is replaced with the first memory card, which makes it possible to talk over the telephone. Therefore, it is possible to provide an expandable mobile radio apparatus that enables functions to be added at the user's request.

Abstract: In a control unit (100), a W-CDMA radio unit(102) is controlled and information on electronic money is loaded from an electronic money server managed and run by a bank or the like into an UIM card (114) via a W-CDMA communication network. Then, in the control unit (100), a BT radio unit (105) is controlled and an identification number of a commodity and electronic money information equivalent to the price of the commodity are transmitted to a vending machine with a BT communication function capable of conducting electronic commerce When mobile radio apparatus receives information on the acceptance of sale of the commodity from the vending machine, information on electronic money equivalent to the amount of user's dues may be subtracted from the UIM card (114). Therefore, it is possible to provide mobile radio apparatus that assures the user a great convenience in conducting electronic commerce.

Abstract: In a mobile radio communication system, a base station is provided for executing radio communication with a radio communication apparatus. The radio communication apparatus includes a signal transmitting/receiving apparatus for mobile communication, which transmits and receives a signal to and from the base station. The apparatus also includes a Bluetooth unit for short-range radio data communication using relatively week radio waves. When the radio communication apparatus is located at a distance communicable with a stationary station based on the Bluetooth system, the radio communication apparatus can acquire, from the stationary station, position information indicative of its position, and shop information related to the position information, etc.

Abstract: An optical disk apparatus in which a head is accommodated in a movable part which moves the head along a guide shaft in a radial direction of an optical disk. The guide shaft is engageable with the movable part and extends in the radial direction of the optical disk. The optical disk apparatus has a guide shaft compression mechanism which applies a compression force toward the movable part, which force is distributed, approximately uniformly, along the radial direction of the optical disk, to the guide shaft so that the movable part can be properly engaged with the guide shaft so as to move smoothly and stably along the guide shaft in the radial direction of the optical disk.

Abstract: A disk storage device includes a head part which writes data into a storage disk loaded into the disk storage device and reads data from the storage disk, a linear actuator moving the head part in radial directions of the storage disk, an eject member which is operated when the storage disk is ejected, and a movement mechanism which moves the storage disk to an eject portion in response to an operation of the eject member and which moves the storage disk to a read/write position. A lock part, which has a lock member cooperating with the movement mechanism, keeps, in response to the operation of the eject member, the head part stationary at the eject position by the lock member which engages with one of the head part and the linear actuator.

Abstract: A magneto-optical disk storage has an erroneous insertion preventing mechanism which projects into a holder so that it can touch the magneto-optical disk cartridge in order to prevent the same from being inserted. The erroneous insertion preventing mechanism mechanically engages with the magneto-optical disk cartridge and moves in a direction approximately vertical to the recording suface of the magneto-optical disk to allow the magneto-optical disk cartridge to be inserted only if the magneto-optical disk cartridge is being inserted into the holder with a correct orientation.

Abstract: A magneto-optic disk unit includes a cartridge holder having an insertion opening, an inside surface and first and second surfaces, an erroneous insertion preventing mechanism having at one end a stopper portion for prohibiting erroneous insertion of a magnetic disk cartridge and at the other end an insertion detecting portion for detecting insertion of a magnetic-optic disk cartridge, and a supporting mechanism for rotatably supporting the erroneous insertion preventing mechanism. The insertion detecting portion projects inside of the cartridge holder from an upper surface of the cartridge holder, so that when the magneto-optic disk cartridge is inserted the insertion detecting portion moves outside of the cartridge holder to allow insertion of the magneto-optic disk cartridge, and that when the magnetic disk cartridge is inserted the insertion detecting portion does not substantially move, thus permitting the stopper portion to prevent insertion of the magnetic disk cartridge.