Patents by Inventor Keiko Hiraki

Keiko Hiraki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing pluripotent stem cells
    Patent number: 10851342
    Abstract: The present invention allows a TET1 protein to be more stably expressed in human pluripotent stem cells than in the past by, inter alia, substituting the second amino acid from the amino terminal of a TET1 protein with a different amino acid. Furthermore, upon differentiation of said pluripotent stem cells, it is possible to quickly eliminate the expression of, inter alia, NANOG, which is an inhibitor of differentiation and promote the expression of factors related to differentiation by introducing a variant TET1 protein to a pluripotent stem cell. The present invention provides a method for manufacturing pluripotent stem cells with increased differentiation potential, and a substance that is useful to said method.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: December 1, 2020
    Assignee: Saitama Medical University
    Inventors: Hidemasa Kato, Yosuke Moriyama, Keiko Hiraki, Akihiko Okuda
  • Method for Producing Pluripotent Stem Cells
    Publication number: 20180094239
    Abstract: The present invention allows a TET1 protein to be more stably expressed in human pluripotent stem cells than in the past by, inter alia, substituting the second amino acid from the amino terminal of a TET1 protein with a different amino acid. Furthermore, upon differentiation of said pluripotent stem cells, it is possible to quickly eliminate the expression of, inter alia, NANOG, which is an inhibitor of differentiation and promote the expression of factors related to differentiation by introducing a variant TET1 protein to a pluripotent stem cell. The present invention provides a method for manufacturing pluripotent stem cells with increased differentiation potential, and a substance that is useful to said method.
    Type: Application
    Filed: December 14, 2017
    Publication date: April 5, 2018
    Inventors: Hidemasa Kato, Yosuke Moriyama, Keiko Hiraki, Akihiko Okuda
  • Method for producing pluripotent stem cells
    Patent number: 9868934
    Abstract: The present invention allows a TET1 protein to be more stably expressed in human pluripotent stem cells than in the past by, inter alia, substituting the second amino acid from the amino terminal of a TET1 protein with a different amino acid. Furthermore upon differentiation of said pluripotent stem cells, it is possible to quickly eliminate the expression of, inter alia, NANOG, which is an inhibitor of differentiation and promote the expression of factors related to differentiation by introducing a variant TET1 protein to a pluripotent stem cell. The present invention provides a method for manufacturing pluripotent stem cells with increased differentiation potential, and a substance that is useful to said method.
    Type: Grant
    Filed: October 29, 2013
    Date of Patent: January 16, 2018
    Assignee: Saitama Medical University
    Inventors: Hidemasa Kato, Yosuke Moriyama, Keiko Hiraki, Akihiko Okuda
  • Method for Producing Pluripotent Stem Cells
    Publication number: 20150275171
    Abstract: The present invention allows a TET1 protein to be more stably expressed in human pluripotent stem cells than in the past by, inter alia, substituting the second amino acid from the amino terminal of a TET1 protein with a different amino acid. Furthermore upon differentiation of said pluripotent stem cells, it is possible to quickly eliminate the expression of, inter alia, NANOG, which is an inhibitor of differentiation and promote the expression of factors related to differentiation by introducing a variant TET1 protein to a pluripotent stem cell. The present invention provides a method for manufacturing pluripotent stem cells with increased differentiation potential, and a substance that is useful to said method.
    Type: Application
    Filed: October 29, 2013
    Publication date: October 1, 2015
    Applicant: Saitama Medical University
    Inventors: Hidemasa Kato, Yosuke Moriyama, Keiko Hiraki, Akihiko Okuda