Patents by Inventor Keiko Ikeda
Keiko Ikeda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11371611Abstract: There is provided a seal member for a bearing comprising a molded rubber article and a core metal, wherein the molded rubber article is produced by vulcanization-molding a rubber composition comprising 100 parts by mass of a rubber (A) containing an acrylic acid ester as a main component, 1 to 30 parts by mass of a carbon material (B), and 10 to 100 parts by mass of a carbon black (C) having a DBP oil absorption of 20 mL/100 g or more and less than 150 mL/100 g; the carbon material (B) is a carbon nanotube (B1) or a carbon black (B2) having a DBP oil absorption of 150 mL/100 g or more and 1000 mL/100 g or less; and a volume resistivity of the molded rubber article is 1×106 ?·cm or less.Type: GrantFiled: March 9, 2020Date of Patent: June 28, 2022Assignee: UCHIYAMA MANUFACTURING CORP.Inventors: Keiko Ikeda, Yoshihiko Yamaguchi, Tomohisa Yamamoto, Tatsuo Katayama
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Publication number: 20200300363Abstract: There is provided a seal member for a bearing comprising a molded rubber article and a core metal, wherein the molded rubber article is produced by vulcanization-molding a rubber composition comprising 100 parts by mass of a rubber (A) containing an acrylic acid ester as a main component, 1 to 30 parts by mass of a carbon material (B), and 10 to 100 parts by mass of a carbon black (C) having a DBP oil absorption of 20 mL/100 g or more and less than 150 mL/100 g; the carbon material (B) is a carbon nanotube (B1) or a carbon black (B2) having a DBP oil absorption of 150 mL/100 g or more and 1000 mL/100 g or less; and a volume resistivity of the molded rubber article is 1×106 ?·cm or less.Type: ApplicationFiled: March 9, 2020Publication date: September 24, 2020Applicant: UCHIYAMA MANUFACTURING CORP.Inventors: Keiko IKEDA, Yoshihiko YAMAGUCHI, Tomohisa YAMAMOTO, Tatsuo KATAYAMA
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Patent number: 8554493Abstract: Cypoviruses and baculoviruses are notoriously difficult to eradicate because the virus particles are embedded in micron-sized protein crystals called polyhedra. The remarkable stability of polyhedra means that like bacterial spores these insect viruses remain infectious for years in soil. Although these unique in vivo protein crystals have been extensively characterized since the early 1900s, their atomic organization remains elusive. Here we describe the 2 crystal structure of both recombinant and infectious silkworm cypovirus polyhedra determined using 5-12 micron crystals purified from insect cells. These are the smallest crystals yet used for de novo X-ray protein structure determination. It was found that polyhedra are made of trimers of the viral polyhedrin protein and contain nucleotides. Although the shape of these building blocks is reminiscent of some capsid trimers, polyhedrin has a new fold and has evolved to assemble in vivo into 3-D cubic crystals rather than icosahedral shells.Type: GrantFiled: February 28, 2008Date of Patent: October 8, 2013Assignees: National University Corporation Kyoto Institute of Technology, Protein Crystal CorporationInventors: Peter Metcalf, Fasseli Joseph Coulibaly, Hajime Mori, Norio Hamada, Keiko Ikeda, Yui Lam Elaine Chiu, Hiroshi Ijiri
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Publication number: 20100216651Abstract: Cypoviruses and baculoviruses are notoriously difficult to eradicate because the virus particles are embedded in micron-sized protein crystals called polyhedra. The remarkable stability of polyhedra means that like bacterial spores these insect viruses remain infectious for years in soil. Although these unique in vivo protein crystals have been extensively characterized since the early 1900s, their atomic organization remains elusive. Here we describe the 2 crystal structure of both recombinant and infectious silkworm cypovirus polyhedra determined using 5-12 micron crystals purified from insect cells. These are the smallest crystals yet used for de novo X-ray protein structure determination. It was found that polyhedra are made of trimers of the viral polyhedrin protein and contain nucleotides. Although the shape of these building blocks is reminiscent of some capsid trimers, polyhedrin has a new fold and has evolved to assemble in vivo into 3-D cubic crystals rather than icosahedral shells.Type: ApplicationFiled: February 28, 2008Publication date: August 26, 2010Applicants: National University Corporation Kyoto Institute of Technology, Protein Crystal CorporationInventors: Peter Metcalf, Fasseli Joseph Coulibaly, Hajime Mori, Norio Hamada, Keiko Ikeda, Yui Lam Elaine Chiu, Hiroshi Ijiri
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Patent number: 7619060Abstract: It is intended to provide a protein complex and a production process whereby the protein complex can be efficiently produced without lowering its function. It is also intended to provide use of the protein complex in a biosensor, an immobilized enzyme and so on. A protein complex comprising a polyhedral protein having an insect virus encapsulated therein and a target protein having a restricted region of a capsid protein VP3 of cytoplasmic polyhedrosis virus, more specifically, a region which is either a region from the N-terminus to the 40th amino acid residue or a region from the 41st amino acid residue to the 79th amino acid residue as an embedding signal for polyhedron, and a process for producing the same. The polyhedral protein has an effect on improvement in the stability of the target protein, protection thereof or improvement in the preservation properties thereof, or a combination thereof.Type: GrantFiled: January 7, 2004Date of Patent: November 17, 2009Assignee: Protein Crystal Co., Ltd.Inventor: Keiko Ikeda
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Patent number: 7432347Abstract: To provide a useful objective protein coated with a protective protein, a protein complex that is produced in cells and has a structure that the objective protein is occluded with the viral occlusion body protein. A protein complex having the structure that the objective protein is occluded with the viral occlusion body protein, produced in insect cells or plant cells, preferably produced by incorporation of the objective protein in the crystalline form during crystallization of polyhedron derived from polyhedrosis virus, preferably a protein complex in which the polyhedrin contributes to improvement of stability, or protection, or improvement of preservability, or combination thereof, of the objective protein.Type: GrantFiled: October 30, 2001Date of Patent: October 7, 2008Assignee: Protein Crystal Co., LtdInventors: Yoshimoto Ohta, Hajime Mori, Keiko Ikeda
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Publication number: 20060155114Abstract: It is intended to provide a protein complex and a production process whereby the protein complex can be efficiently produced without lowering its function. It is also intended to provide use of the protein complex in a biosensor, an immobilized enzyme and so on. A protein complex comprising a polyhedral protein having an insect virus encapsulated therein and a target protein having a restricted region of a capsid-protein VP3 of cytoplasmic polyhedrosis virus, more specifically, a region which is either a region from the N-terminus to the 40th amino acid residue or a region from the 41st amino acid residue to the 79th amino acid residue as an embedding signal for polyhedron, and a process for producing the same. The polyhedral protein has an effect on improvement in the stability of the target protein, protection thereof or improvement in the preservation properties thereof, or a combination of any of these.Type: ApplicationFiled: January 7, 2004Publication date: July 13, 2006Applicant: Protein Crystal Co., Ltd.Inventor: Keiko Ikeda
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Publication number: 20040059091Abstract: A protein complex that is produced in cells and has a structure that the objective protein is occluded with the viral occlusion body protein. A protein complex having the structure that the objective protein is occluded with the viral occlusion body protein, produced in insect cells or plant cells, preferably produced by incorporation of the objective protein in the crystalline form during crystallization of polyhedron derived from polyhedrosis virus, preferably a protein complex in which the polyhedrin contributes to improvement of stability, or protection, or improvement of preservability, or combination thereof, of the objective protein.Type: ApplicationFiled: September 10, 2003Publication date: March 25, 2004Applicant: PROTEIN CRYSTAL CO., LTD.Inventors: Yoshimoto Ohta, Hajime Mori, Keiko Ikeda