Abstract: An object of the present invention is to provide an anti-tumor agent that exhibits a remarkably excellent anti-tumor effect. According to the present invention, there is provided an anti-tumor agent for curing cancer, the anti-tumor agent having a liposome which has an inner water phase and having an aqueous solution which is an outer water phase and disperses the liposome, in which the liposome encompasses topotecan or a salt thereof, a lipid constituting the liposome contains a lipid modified with polyethylene glycol, dihydrosphingomyelin, and cholesterol, the inner water phase contains an ammonium salt, and the topotecan or the salt thereof encompassed in the liposome is administered at a dose rate of 0.1 mg/m2 body surface area to 10 mg/m2 body surface area, in terms of topotecan per administration.

Abstract: A stretchable film including a stretchable film layer, a first skin layer disposed on the stretchable film layer on a first surface side, and a second skin layer disposed on the stretchable film layer on a second surface side, in which the stretchable film layer contains an elastomer, the first skin layer and the second skin layer contain a resin which does not have adhesiveness at 60° C., and the thickness of each of the first skin layer and the second skin layer is 0.1 ?m to 4 ?m.

Abstract: [Problem] To provide a novel nucleic acid aptamer for a vascular endothelial growth factor receptor, said nucleic acid aptamer being useful for the diagnosis and treatment of various diseases associated with VEGFs that can regulate angiogenesis and receptors for the VEGFs, e.g., tumor angiogenesis, diabetic retina and chronic rheumatoid arthritis. [Solution] A nucleic acid aptamer characterized by comprising a nucleotide sequence represented by any one of SEQ ID NOs: 1 to 5, and also characterized by being capable of bonding to a human VEGF receptor specifically. In a preferred embodiment of the nucleic acid aptamer, a primer recognition sequence, a fluorescent label, or a biotin molecule, an avidin molecule, a streptavidin molecule or other specific binding tag peptide may be linked to the 5?- or 3?-terminal of the nucleic acid aptamer for the purpose of making it possible to detect the nucleic acid aptamer easily.

Abstract: [Problem] To provide a novel nucleic acid aptamer for a vascular endothelial growth factor receptor, said nucleic acid aptamer being useful for the diagnosis and treatment of various diseases associated with VEGFs that can regulate angiogenesis and receptors for the VEGFs, e.g., tumor angiogenesis, diabetic retina and chronic rheumatoid arthritis. [Solution] A nucleic acid aptamer characterized by comprising a nucleotide sequence represented by any one of SEQ ID NOs: 1 to 5, and also characterized by being capable of bonding to a human VEGF receptor specifically. In a preferred embodiment of the nucleic acid aptamer, a primer recognition sequence, a fluorescent label, or a biotin molecule, an avidin molecule, a streptavidin molecule or other specific binding tag peptide may be linked to the 5?- or 3?-terminal of the nucleic acid aptamer for the purpose of making it possible to detect the nucleic acid aptamer easily.

Abstract: A stretchable film including a stretchable film layer, a first skin layer disposed on the stretchable film layer on a first surface side, and a second skin layer disposed on the stretchable film layer on a second surface side, in which the stretchable film layer contains an elastomer, the first skin layer and the second skin layer contain a resin which does not have adhesiveness at 60° C., and the thickness of each of the first skin layer and the second skin layer is 0.1 ?m to 4 ?m.

Abstract: An improved diaper having a three-dimensional configuration, made substantially of soft, flexible liquid absorbing material. The diaper comprises a substantially flat, rectangular main body, a side wall integrally formed on each of opposing sides of the main body and a sink interposed between the sidewalls. The diaper may also comprise a raised part integrally formed on one end of the main body, the height thereof is higher than that of the sidewalls, and an end wall integrally formed on the other end of the main body, having substantially the same height as that of the main body, so that the sink is enclosed by the side walls, the raised part, and the end wall, whereby discharged body excretions are kept from spilling out of the diaper.