Abstract: A learning diagnosis apparatus performs learning from failure data to create a diagnostic model, and stores a model, a failure cause part, and sensor data of the equipment in a rare case data table when the number of cases of the failure cause part of the equipment is less than a predetermined number. Then, based on the diagnostic model created by a learning unit, an estimated probability of causing a failure is calculated for each part of the equipment in which a failure has occurred. Based on the rare case data table, a sensor data match rate between sensor data of the equipment in which the failure has occurred and past sensor data of the model of the equipment is calculated. Then, the calculated sensor data match rate for each part of the equipment in which the failure has occurred is displayed.

Abstract: The object of the present invention is to provide a method for determining the sensitivity of a subject to an SGLT2 inhibitor, and a sensitivity marker for the SGLT2 inhibitor. The present invention provides a method for determining the sensitivity of a subject to an SGLT2 inhibitor, comprising measuring a biomarker in the biological sample of a subject, and determining the sensitivity of the subject to the SGLT2 inhibitor using the measured biomarker value as an indicator.

Abstract: An optically active dihydroxyheptenoic acid ester having an aromatic group is separated from a solution containing a mixture of optical isomers of digydroxyheptenoic acid ester by liquid chromatography with a packing material constituted of a carrier and a polysaccharide derivative carried on the carrier. The polysaccharide derivative is a polysaccharide in which the hydrogen atoms constituting the hydroxyl and amino groups are partially or all replaced by one or more kinds of groups selected from among carbamoyl groups monosubstituted with aromatic groups having specific alkyl groups and benzoyl groups having specific alkyl groups. According to the invention, optically active dihydroxyheptenoic acid esters can be separated more distinctly.

Abstract: A separating agent for optical isomers which contains a polysaccharide derivative as an active ingredient, wherein the polysaccharide derivative serving as an active ingredient is one formed by replacing at least part of the hydrogen atoms of the hydroxyl groups and amino groups of a polysaccharide with at least one member selected out of a benzoyl group having a specific alkyl group and a carbamoyl group in which one hydrogen atom has been replaced with an aromatic group having a specific alkyl group. It is a novel separating agent for optical isomers which has the high ability to asymmetrically identify the target compound to be analyzed and isolated.

Abstract: An optically active dihydroxyheptenoic acid ester having an aromatic group is separated from a solution containing a mixture of optical isomers of digydroxyheptenoic acid ester by liquid chromatography with a packing material constituted of a carrier and a polysaccharide derivative carried on the carrier. The polysaccharide derivative is a polysaccharide in which the hydrogen atoms constituting the hydroxyl and amino groups are partially or all replaced by one or more kinds of groups selected from among carbamoyl groups monosubstituted with aromatic groups having specific alkyl groups and benzoyl groups having specific alkyl groups. According to the invention, optically active dihydroxyheptenoic acid esters can be separated more distinctly.

Abstract: The present invention relates to a process for producing pure water having a total organic carbon content of not more than 200 ppb instantly after start of the operation of a high purity water system, comprising using as an ion exchange resin a specific strongly basic anion exchange resin and passing raw water through the high purity water system at a space velocity of not less than 20. The produced pure water is capable of producing tasteless and odorless pure water instantly after start of the operation of the high purity water system.