Patents by Inventor Keiko Nakahara

Keiko Nakahara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220096707
    Abstract: A hemostatic material includes a lipid that can accelerate adhesion or aggregation of platelets even if the lipid does not carry a protein or a peptide involved in adhesion or aggregation of platelets such as GPIb and H12 and, to achieve the object, provides a hemostatic material including a water-insoluble base and a lipid supported on a surface of the base, wherein the lipid includes one or two or more anionic lipids.
    Type: Application
    Filed: October 17, 2019
    Publication date: March 31, 2022
    Applicant: Toray Industries, Inc.
    Inventors: Shinji Takeoka, Keiko Nakahara, Mamoru Nishiura, Shinya Otsubo, Hajimu Kurumatani, Toru Arakane, Masanobu Takeda, Makoto Nakahara, Kumi Oyama
  • Publication number: 20210387943
    Abstract: A carboxylic acid-type lipid can accelerate adhesion or aggregation of platelets even if the carboxylic acid-type lipid does not carry a protein involved in adhesion or aggregation of platelets or a peptide corresponding to an active site of the protein; a lipid particle and a lipid membrane each include the carboxylic acid-type lipid; and a platelet aggregation accelerating agent, a platelet adhesion accelerating agent, a hemostatic agent and a platelet substitute each include the carboxylic acid-type lipid, the lipid particle or the lipid membrane. A carboxylic acid-type lipid is selected from carboxylic acid-type lipids represented by formulas (I) to (VI), a lipid particle includes the carboxylic acid-type lipid, a lipid membrane includes the carboxylic acid-type lipid, and a platelet aggregation accelerating agent, a platelet adhesion accelerating agent, a hemostatic agent and a platelet substitute each include the carboxylic acid-type lipid, the lipid particle or the lipid membrane.
    Type: Application
    Filed: October 17, 2019
    Publication date: December 16, 2021
    Inventors: Shinji Takeoka, Keiko Nakahara, Mamoru Nishiura, Shinya Otsubo, Hajimu Kurumatani, Toru Arakane
  • Patent number: 9555077
    Abstract: An object of the present invention is to provide a hypothermic agent for an animal, a therapeutic agent for hyperthermia in an animal, etc. The present invention provides a hypothermic agent for an animal, a therapeutic agent for hyperthermia in an animal, etc., the agents etc. comprising desacyl ghrelin or its derivative, or a pharmaceutically acceptable salt thereof as an active ingredient.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: January 31, 2017
    Assignees: UNIVERSITY OF MIYAZAKI, NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Noboru Murakami, Keiko Nakahara, Kenji Kangawa
  • Publication number: 20150238570
    Abstract: An object of the present invention is to provide a hypothermic agent for an animal, a therapeutic agent for hyperthermia in an animal, etc. The present invention provides a hypothermic agent for an animal, a therapeutic agent for hyperthermia in an animal, etc., the agents etc. comprising desacyl ghrelin or its derivative, or a pharmaceutically acceptable salt thereof as an active ingredient.
    Type: Application
    Filed: September 2, 2011
    Publication date: August 27, 2015
    Applicants: UNIVERSITY OF MIYAZAKI, DAIICHI SANKYO COMPANY, LIMITED, NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER
    Inventors: Noboru Murakami, Keiko Nakahara, Kenji Kangawa, Yujiro Hayashi
  • Patent number: 9078868
    Abstract: An object of the present invention is to provide a therapeutic agent for accelerating recovery to accelerate a return to normal physical conditions by administering to an animal not in good health and under medical treatment, a treatment method, and the like. There is provided a therapeutic agent for accelerating recovery for animal use to accelerate the improvement of a physical condition of an animal under medical treatment which has a decreased activity (vigor) and is exhausted, which contains ghrelin or a derivative thereof or a pharmaceutically acceptable salt thereof as an active ingredient and improves one or more of evaluation parameters consisting of activity (vigor), blood cell test values, biochemical test values, body temperature, the degree of anger or anxiety, and respiratory rate.
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: July 14, 2015
    Assignees: UNIVERSITY OF MIYAZAKI, NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER, DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Noboru Murakami, Keiko Nakahara, Kenji Kangawa, Yujiro Hayashi
  • Publication number: 20130005654
    Abstract: An object of the present invention is to provide a therapeutic agent for accelerating recovery to accelerate a return to normal physical conditions by administering to an animal not in good health and under medical treatment, a treatment method, and the like. There is provided a therapeutic agent for accelerating recovery for animal use to accelerate the improvement of a physical condition of an animal under medical treatment which has a decreased activity (vigor) and is exhausted, which contains ghrelin or a derivative thereof or a pharmaceutically acceptable salt thereof as an active ingredient and improves one or more of evaluation parameters consisting of activity (vigor), blood cell test values, biochemical test values, body temperature, the degree of anger or anxiety, and respiratory rate.
    Type: Application
    Filed: January 14, 2011
    Publication date: January 3, 2013
    Applicants: University of Miyazaki, Daiichi Sankyo Company, Limited, National Cerebral and Cardiovascular Center
    Inventors: Noboru Murakami, Keiko Nakahara, Kenji Kangawa, Yujiro Hayashi
  • Patent number: 7847147
    Abstract: An object of the present invention is to provide a mouse which has the characteristics of early developing visceral fat type obesity and also has concurrent diabetes and hyperlipemia and in which the trait is genetically established and recessively inherited. An ICR-derived mouse strain, Daruma, spontaneously developing obesity, exhibiting autosomal recessive inheritance for the trait of spontaneously developing obesity, and becoming obese only in the homozygous type is provided.
    Type: Grant
    Filed: August 15, 2007
    Date of Patent: December 7, 2010
    Assignee: University of Miyazaki
    Inventors: Noboru Murakami, Keiko Nakahara
  • Publication number: 20100143310
    Abstract: The invention provides a spinal neuron damage treating agent for use in the treatment of spinal neuron damage, or an agent for promoting the proliferation of spinal neuronal precursor cells in the culture of spinal neuronal precursor cells, or an agent for promoting the regeneration of spinal nerves after transplantation of cultured spinal neuronal precursor cells, and the like. The invention provides an agent that contains a substance (e.g., ghrelin) that acts on the growth hormone secretagogue-receptor as an active ingredient, the agent being a spinal neuron damage treating agent for use in the treatment of spinal neuron damage, or an agent for promoting the proliferation of cultured spinal neuronal precursor cells in the culture of spinal neuronal precursor cells, or an agent for promoting the regeneration of spinal nerves after transplantation of cultured spinal neuronal precursor cells, and the like.
    Type: Application
    Filed: August 10, 2007
    Publication date: June 10, 2010
    Applicant: JAPAN AS REPRESENTED BY PRESIDENT OF NATIONAL CARDIOVASCULAR CENTER
    Inventors: Noboru Murakami, Keiko Nakahara, Miho Hashimoto, Yujiro Hayashi, Kenji Kangawa
  • Publication number: 20090305969
    Abstract: The present invention provides a novel therapeutic agent for skin injuries and a skin regeneration accelerator. The therapeutic agent for skin injuries and the skin regeneration accelerator containing desacyl ghrelin or a pharmaceutically acceptable salt thereof as an active ingredient.
    Type: Application
    Filed: November 21, 2006
    Publication date: December 10, 2009
    Inventors: Noboru Murakami, Keiko Nakahara, Kenji Kangawa, Yujiro Hayashi
  • Publication number: 20090181888
    Abstract: The present invention provides a novel therapeutic agent for skin injuries and a skin regeneration accelerator. The therapeutic agent for skin injuries and the skin regeneration accelerator containing a substance acting on a growth hormone secretagogue receptor or a pharmaceutically acceptable salt thereof as an active ingredient.
    Type: Application
    Filed: November 21, 2006
    Publication date: July 16, 2009
    Inventors: Noboru Murakami, Keiko Nakahara, Kenji Kangawa, Yujiro Hayashi
  • Publication number: 20080209580
    Abstract: An object of the present invention is to provide a mouse which has the characteristics of early developing visceral fat type obesity and also has concurrent diabetes and hyperlipemia and in which the trait is genetically established and recessively inherited. An ICR-derived mouse strain, Daruma, spontaneously developing obesity, exhibiting autosomal recessive inheritance for the trait of spontaneously developing obesity, and becoming obese only in the homozygous type is provided.
    Type: Application
    Filed: August 15, 2007
    Publication date: August 28, 2008
    Inventors: Noboru Murakami, Keiko Nakahara