Abstract: A laminate is provided which can form packaging bags having a wide range of packaging feasible temperatures and excellent high-speed liquid packaging properties. The laminate includes a sealant layer and an intermediate layer disposed in contact with the sealant layer, the sealant layer including an ethylene/?-olefin copolymer satisfying the requirements (x0) to (x3): (x0) The copolymer is a copolymer of ethylene and a C3-C20 ?-olefin (x1) The MFR is 1 to 50 g/10 min (x2) The density is 890 to 910 kg/m3 (x3) 0.35<?(80)/?<0.85 and 0.60<?(100)/?<0.85, wherein ?H is the total heat of melting observed during DSC and ?H(T) is the heat of melting observed during heating from 0° C. to T° C.

Abstract: Disclosed is a method for producing regulatory T cells, the method comprising: (1) differentiating cells that can differentiate into regulatory T cells, into which an expression construct is introduced, into regulatory T cells, the expression construct comprising: (a) conserved non-coding sequence (CNS) 1, CNS2, and CNS3 of Foxp3 gene; (b) a promoter; and (c) a nucleic acid encoding FOXP3. Also disclosed are regulatory T cells obtained by the method, and a pharmaceutical composition comprising the regulatory T cells.

Abstract: A stretched film including a polyethylene-based resin composition satisfying the following requirements (1) to (3): (1) a melt flow rate (190° C., 2.16 kg load) is 0.01 g/10 min or more and 2.0 g/10 min or less; (2) a density is 935 kg/m3 or more and 970 kg/m3 or less; and (3) a ratio of a melt index (I21: 190° C., 21.6 kg load) to a melt index (I2: 190° C., 2.16 kg load), I21/I2 is 80 or more.

Abstract: The present invention provides a therapeutic agent for an immune/inflammatory disease comprising an anti-human TIGIT antibody, which activates a suppressive immune checkpoint molecule (TIGIT), as an active ingredient. Also, provided is an antibody having the following characteristics a) and b): a) the third CDR of heavy chain variable region comprises the amino acid sequence of SEQ ID NO: 4 b) the third CDR of light chain variable region comprises the amino acid sequence of SEQ ID NO: 6.

Abstract: An ethylene-based resin composition having the following requirements (1) to (4) as a material such as packaging material, a film having strength for the protection and rigidity (e.g., easy opening and self-standability on packaging contents) in an excellent balance: (1) A melt flow rate (190° C., 2.16 kg load) is 0.1 g/10 min or more and 1.0 g/10 min or less, (2) a density is 915 kg/m3 or more and 935 kg/m3 or less, (3) a melt index (121: 190° C., 21.6 kg load) is 45 or less, and (4) a ratio of the amount of heat of fusion at 120° C. or higher (Hh/Ht), which is the ratio of the amount of heat of fusion (Hh) determined from a DSC curve at 120° C. or higher to the total amount of heat of fusion (Ht) determined from a DSC curve of DSC measurement, is 10% or more and 55% or less.

Abstract: Disclosed is a method for detecting regulatory dendritic cells, the method comprising step a: detecting the presence or absence of one or more types of molecules on a cell surface in a cell population that comprises regulatory dendritic cells; and step b: identifying regulatory dendritic cells on the basis of the presence or absence of the one or more types of molecules. Also disclosed is a method for producing a cell population enriched for regulatory dendritic cells, the method comprising step 1: detecting the presence or absence of one or more types of molecules on a cell surface in a cell population that comprises regulatory dendritic cells; and step 2: obtaining a cell population enriched for regulatory dendritic cells on the basis of the presence or absence of the one or more types of molecules. Further disclosed is a cell population enriched for regulatory dendritic cells obtained by the method.

Abstract: [Object] A laminate is provided which can form packaging bags having a wide range of packaging feasible temperatures and excellent high-speed liquid packaging properties. [Solution] The laminate includes a sealant layer and an intermediate layer disposed in contact with the sealant layer, the sealant layer including an ethylene/?-olefin copolymer satisfying the requirements (x0) to (x3). (x0) The copolymer is a copolymer of ethylene and a C3-C20 ?-olefin. (x1) The MFR is 1 to 50 g/10 min. (x2) The density is 890 to 910 kg/m3. (x3) 0.35??H (80)/?H?0.85, and 0.60??H (100)/?H?0.85, wherein ?H is the total heat of melting observed during DSC, and ?H (T) is the heat of melting observed during heating from 0° C. to T° C.

Abstract: An object of the present invention is to provide a resin composition for a sealant combining bag manufacturing performance and inflation film process-ability (extrusion properties, bubble stability), a sealant film and a heat-fusible film produced using the composition, and a package produced using the heat-fusible film. The ethylene-based resin composition for a sealant according to the present invention satisfies the following requirements (1) to (3) simultaneously: (1) a melt index (I21: 190° C., 21.6 kg load) is 42 to 80 g/10 min; (2) a ratio I21/I2 of the melt index (I21: 190° C., 21.6 kg load) to a melt index (I2: 190° C., 2.16 kg load) is 5 to 25; (3) a melt tension (190° C.) is 25 to 180 mN.

Abstract: A laminate from which containers with improved transparency, high low-temperature impact strength and rigidity can be made. The laminate includes a resin layer [I] containing 60.0% by mass or more and 85.0% by mass or less of a propylene-based polymer (A) and 15.0% by mass or more and 40.0% by mass or less of an ethylene-based polymer (B), and a resin layer [II] containing 80.0% by mass or more and 99.9% by mass or less of a propylene-based polymer (A), 0.0% by mass or more and less than 15.0% by mass of an ethylene-based polymer (B), and 0.1% by mass or more and 20.0% by mass or less of a nucleating agent (C). The propylene-based polymer (A) and the ethylene-based polymer (B) satisfy specific requirements in both of the resin compositions [I] and [II].