Abstract: An object of present invention is to provide a compound or a salt thereof constituting lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids, and to provide lipid particles and pharmaceutical composition using the compound or a salt thereof, which can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids. According to an aspect of the present invention, a compound represented by Formula (1) or a salt thereof is provided. In the formula, each symbol has a meaning defined in the present specification.

Abstract: The present invention provides a heterocyclic compound having a HDAC6 inhibitory action, which is useful for the treatment of central nervous system diseases including neurodegenerative diseases, and the like, and a medicament comprising the compound. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.

Abstract: An amidine compound represented by formula (I) (wherein A1 represents a nitrogen atom or a group represented by formula CR6; A2 and A3 are the same as or different from each other and independently represent a nitrogen atom or a group represented by formula CH; R1 represents an aryl group which may be substituted by 1 to 5 substituents independently selected from a substituent group (2) or the like; R2 and R3 are the same as or different from each other and independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 haloalkyl group or a C1-6 alkoxy group; and R4 and R5 are the same as or different from each other and independently represent a hydrogen atom, a C1-6 haloalkyl group, a C1-6 alkyl group or the like) or a salt thereof. The compound is useful as an anti-fungal agent.

Abstract: A peak-relevant value device acquires a peak-relevant value (for example, the peak value of an R wave (R peak value)) every cycle from an electrocardiogram acquired. The frequencies of the peak-relevant value acquired as time-series data and the magnitudes for the respective frequencies are analyzed. A peak-relevant value LF calculating device calculates an LF component (peak-relevant value LF component) from the frequency component of the peak-relevant value. An interval acquiring device acquires the interval between characteristic points of the electrocardiographic complex from the electrocardiogram acquired and the frequencies of the feature point interval acquired as time-series data to acquire the magnitudes of the respective frequency component are analyzed.

Abstract: The purpose of the present invention is to provide a novel compound which has an anti-fungal activity on pathogenic fungi including fungi belonging to the genus Candida, the genus Aspergillus and the genus Trichophyton and is useful as a medicinal agent.

Abstract: A device for objectively judging pain is disclosed. A peak-relevant value means (10) acquires a peak-relevant value (for example, the peak value of an R wave (R peak value)) every cycle from an electrocardiogram acquired. A peak-relevant value frequency analyzing means (12) analyzes the frequencies of the peak-relevant value acquired as time-series data and the magnitudes for the respective frequencies. A peak-relevant value LF calculating means (14) calculates an LF component (peak-relevant value LF component) from the frequency component of the peak-relevant value. An interval acquiring means (4) acquires the interval between characteristic points of the electrocardiographic complex (for example, the time intervals between R waves (RR interval)) from the electrocardiogram acquired. An interval frequency analyzing means (6) analyzes the frequencies of the feature point interval acquired as time-series data to acquire the magnitudes of the respective frequency component.

Abstract: The green vegetable puree production process according to the present invention, which contains a grinding step and an acid addition step and does not include a heating step, produces an unheated green vegetable puree having no catalase activity, containing an acid or acids and having a pH of 2.7 to 4.1. The puree sufficiently maintains the original flavor and taste and freshness of vegetables and is suitable for use in the preparation of foods, especially for vegetable juices.

Abstract: Disclosed is a method for producing 5-phenoxycarbonylbenzotriazole (I): by reacting 1H-benzotriazole-5-carboxylic acid (II): with diphenyl carbonate (III):

Abstract: A remedy for tragomaschalia characterized in that it conntains an effective amount of adrenocorticosteroid and from 1 to 10% by weight of an extraction product from lactic acid fermentation based on one gram of a base. The extraction product from lactic acid fermentation has a metabolism product of lactic acid bacteria and ingredients of bacterial cells of lactic acid bacteria together. By inhibition of the secretion itself of a odoriferous steroid which is the cause of tragomaschalia, remetabolism and generation of such a steroid compound by tragomaschalia bacteria are completely eliminated, and there is little fear of adverse drug reactions by the adrenocorticosteroid used for that purpose.

Abstract: A new Combination Washer-Drier System for providing a combination washer and drier that can be mounted in various areas of a building, thereby allowing utilization of an existing fixture such as a toilet or a washbasin for supplying water to the present invention and for draining wash water from the present invention. The inventive device includes a power source, a compact combination washer-drier means connected to the power source, a water supplying means connected to the combination washer-drier means, a controller means electronically connected to the combination washer-drier means, an existing fixture such as a toilet or a washbasin connected to the combination washer-drier means, a mounting means securing the combination washer-drier means to a wall, and a draining means engaging the combination washer-drier means draining waste water from the present invention.

Abstract: The present invention relates to a dust and lint collection device. The device is utilized in the collection and disposal of lint, dust or other such material. In its broadest context, the present invention includes a collection sleeve which is adapted for engagement with the opened end of a flexible bag. The material to be collected is inserted through the sleeve and into the bag. The bag can then be disposed.

Abstract: New application of an aqueous alkali solution of cyclohexylaminopropanesulfonic acid, said acid being contained therein with a specific range of concentration and said solution having a specific range of pH value, as a stopping agent for stopping an enzyme reaction of a dehydrogenase or a dehydrogenase system in a spectrophotometric assay method of an activity of serum enzyme in said enzyme or enzyme system.