Patents by Inventor Keiko Yoshikawa
Keiko Yoshikawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10145794Abstract: A cell information obtaining method comprises causing a plurality of fluorescent substances having different fluorescence wavelengths from each other to be bound to a test substance contained in a cell, applying light to the cell to cause fluorescences having different wavelengths and intensities to be generated from the plurality of fluorescent substances, and obtaining a first fluorescence information and a second fluorescence information on the basis of the generated fluorescences.Type: GrantFiled: October 27, 2016Date of Patent: December 4, 2018Assignee: SYSMEX CORPORATIONInventor: Keiko Yoshikawa
-
Patent number: 9969176Abstract: A controller includes a second controller that periodically performs a flushing operation of injecting a predetermined amount of ink from a nozzle, a third controller that repeatedly performs the flushing operation until a remaining amount of the ink in a storage chamber after the flushing operation is detected by a detector to be a first amount, a first counter that counts a first operation number of times of the flushing operation, and a fourth controller that performs a first cleaning operation of absorbing a fluid in a sealed space by a suction pump when the first operation number of times counted by the first counter reaches a first threshold value.Type: GrantFiled: June 13, 2017Date of Patent: May 15, 2018Assignee: ROLAND DG CORPORATIONInventors: Teppei Sawada, Keiko Yoshikawa
-
Publication number: 20180113117Abstract: A cell information acquisition method may include: binding a binding substance to a receptor on a cell membrane surface of a cell, the binding substance being bindable to the receptor; permeabilizing a cell membrane of the cell after the binding; labeling a receptor in an intracellular area of the cell with a binding substance labeled with a first labeling substance after the permeabilizing; causing a specimen including the cell to flow through a flow path after the labeling; irradiating the cell included in the specimen flowing through the flow path with light; and acquiring a signal based on light generated from the first labeling substance in the cell irradiated with light.Type: ApplicationFiled: October 24, 2017Publication date: April 26, 2018Applicant: SYSMEX CORPORATIONInventors: Keiko YOSHIKAWA, Yuma OKA, Shingo FUJIYAMA
-
Publication number: 20180100871Abstract: A control section causes one dispensing mechanism of either a reagent dispensing mechanism or a sample dispensing mechanism to first discharge a predetermined amount of a liquid into the reaction container, and then, with respect to the cases where the amount of a liquid to be discharged by the other dispensing mechanism is larger or smaller than the amount of the liquid in the reaction container, causes the other dispensing mechanism to discharge the liquid such that the discharge speed in the case where the amount of the liquid to be discharged is larger is decreased relative to the discharge speed in the case where the amount of the liquid to be discharged is smaller.Type: ApplicationFiled: December 11, 2017Publication date: April 12, 2018Inventors: Keiko YOSHIKAWA, Akihisa MAKINO
-
Publication number: 20180074043Abstract: An automatic analyzer which realizes stable reagent heating and high dispensing accuracy includes a thermostat bath for controlling a reagent or a reaction solution in reaction cells arranged on a circumference of a reaction disk to have a constant temperature; a first reagent dispensing mechanism dispenses a reagent into the reaction cells; a photometer detects transmitted light or scattered light in the reaction cell; and a disposable reaction container for allowing the sample and the reagent to mix and react with each other. The analyzer also includes a second reagent dispensing mechanism with a reagent heating function which dispenses the reagent into the disposable reaction container; a coagulation time detection section; a reaction container temperature control block; a reagent dispensing syringe which is connected to the second reagent dispensing mechanism; and a fluid temperature control mechanism which controls the temperature of an internal fluid of the reagent dispensing syringe.Type: ApplicationFiled: November 14, 2017Publication date: March 15, 2018Inventors: Akihisa MAKINO, Keiko YOSHIKAWA, Takeshi YOKOKAWA
-
Publication number: 20170361620Abstract: A controller includes a second controller that periodically performs a flushing operation of injecting a predetermined amount of ink from a nozzle, a third controller that repeatedly performs the flushing operation until a remaining amount of the ink in a storage chamber after the flushing operation is detected by a detector to be a first amount, a first counter that counts a first operation number of times of the flushing operation, and a fourth controller that performs a first cleaning operation of absorbing a fluid in a sealed space by a suction pump when the first operation number of times counted by the first counter reaches a first threshold value.Type: ApplicationFiled: June 13, 2017Publication date: December 21, 2017Inventors: Teppei SAWADA, Keiko YOSHIKAWA
-
Patent number: 9846171Abstract: A control section causes one dispensing mechanism of either a reagent dispensing mechanism or a sample dispensing mechanism to first discharge a predetermined amount of a liquid into the reaction container, and then, with respect to the cases where the amount of a liquid to be discharged by the other dispensing mechanism is larger or smaller than the amount of the liquid in the reaction container, causes the other dispensing mechanism to discharge the liquid such that the discharge speed in the case where the amount of the liquid to be discharged is larger is decreased relative to the discharge speed in the case where the amount of the liquid to be discharged is smaller.Type: GrantFiled: December 13, 2013Date of Patent: December 19, 2017Assignee: Hitachi High-Technologies CorporationInventors: Keiko Yoshikawa, Akihisa Makino
-
Patent number: 9835612Abstract: An automatic analyzer which realizes stable reagent heating and high dispensing accuracy includes a thermostat bath for controlling a reagent or a reaction solution in reaction cells arranged on a circumference of a reaction disk to have a constant temperature; a first reagent dispensing mechanism dispenses a reagent into the reaction cells; a photometer detects transmitted light or scattered light in the reaction cell; and a disposable reaction container for allowing the sample and the reagent to mix and react with each other. The analyzer also includes a second reagent dispensing mechanism with a reagent heating function which dispenses the reagent into the disposable reaction container; a coagulation time detection section; a reaction container temperature control block; a reagent dispensing syringe which is connected to the second reagent dispensing mechanism; and a fluid temperature control mechanism which controls the temperature of an internal fluid of the reagent dispensing syringe.Type: GrantFiled: December 13, 2013Date of Patent: December 5, 2017Assignee: Hitachi High-Technologies CorporationInventors: Akihisa Makino, Keiko Yoshikawa, Takeshi Yokokawa
-
Publication number: 20170315112Abstract: The present invention relates to a method for measuring the cholesterol uptake capacity of lipoproteins. The present invention also relates to a reagent kit for measuring the cholesterol uptake capacity of lipoproteins. The present invention further relates to a tagged cholesterol which can be used in the method and the reagent kit.Type: ApplicationFiled: July 14, 2017Publication date: November 2, 2017Applicant: SYSMEX CORPORATIONInventors: Keiko YOSHIKAWA, Amane HARADA, Katsuhiro MURAKAMI, Maria KIRIYAMA, Keiko MIWA, Takuya KUBO
-
Publication number: 20170269113Abstract: A high-throughput automatic analyzer integrates a biochemical analysis section and a blood coagulation analysis section. The analyzer is capable of achieving a reduction in size, system cost, and lifecycle cost. The automatic analyzer includes: a reaction disk; a first reagent dispensing mechanism that dispenses a reagent to reaction cells on the reaction disk; a photometer that irradiates a reaction solution in the reaction cell with light; a reaction cell cleaning mechanism; a reaction vessel supply unit that supplies a disposable reaction vessel for mixing and reacting a sample and a reagent with each other; a second reagent dispensing mechanism that dispenses a reagent to the disposable reaction vessel; a blood coagulation time measuring section that irradiates a reaction solution in the disposable reaction vessel with light to detect transmitted or scattered light; and a sample dispensing mechanism that dispenses a sample to the reaction cell and the disposable reaction vessel.Type: ApplicationFiled: June 7, 2017Publication date: September 21, 2017Inventors: Akihisa MAKINO, Hajime YAMAZAKI, Keiko YOSHIKAWA, Manabu ANDO, Masahiko IIJIMA
-
Patent number: 9696329Abstract: A high-throughput automatic analyzer integrates a biochemical analysis section and a blood coagulation analysis section. The analyzer is capable of achieving a reduction in size, system cost, and lifecycle cost. The automatic analyzer includes: a reaction disk; a first reagent dispensing mechanism that dispenses a reagent to reaction cells on the reaction disk; a photometer that irradiates a reaction solution in the reaction cell with light; a reaction cell cleaning mechanism; a reaction vessel supply unit that supplies a disposable reaction vessel for mixing and reacting a sample and a reagent with each other; a second reagent dispensing mechanism that dispenses a reagent to the disposable reaction vessel; a blood coagulation time measuring section that irradiates a reaction solution in the disposable reaction vessel with light to detect transmitted or scattered light; and a sample dispensing mechanism that dispenses a sample to the reaction cell and the disposable reaction vessel.Type: GrantFiled: May 24, 2013Date of Patent: July 4, 2017Assignee: Hitachi High-Technologies CorporationInventors: Akihisa Makino, Hajime Yamazaki, Keiko Yoshikawa, Manabu Ando, Masahiko Iijima
-
Publication number: 20170122869Abstract: A cell information obtaining method comprises causing a plurality of fluorescent substances having different fluorescence wavelengths from each other to be bound to a test substance contained in a cell, applying light to the cell to cause fluorescences having different wavelengths and intensities to be generated from the plurality of fluorescent substances, and obtaining a first fluorescence information and a second fluorescence information on the basis of the generated fluorescences.Type: ApplicationFiled: October 27, 2016Publication date: May 4, 2017Inventor: Keiko YOSHIKAWA
-
Patent number: 9506940Abstract: A configuration of detecting light from the front face of a light source is the best for confirming the variation of a light quantity, but when a plurality of light sources are present, as many detectors for checking a light quantity as the light sources are necessary and the apparatus configuration becomes complex. In the present invention, a detector for checking a light source light quantity is installed in a reaction container transfer mechanism used commonly for a plurality of detection sections, and the light quantities of light sources are checked with the detector.Type: GrantFiled: May 24, 2013Date of Patent: November 29, 2016Assignee: Hitachi High-Technologies CorporationInventors: Keiko Yoshikawa, Akihisa Makino
-
Publication number: 20160109469Abstract: Provided is a method of measuring a lipoprotein's capacity to accept cholesterol including the steps of: bringing a lipoprotein in a sample into contact with labeled cholesterol to incorporate the labeled cholesterol into the lipoprotein; bringing the lipoprotein having the labeled cholesterol into contact with an antibody that binds to a lipoprotein to form a complex of the lipoprotein and the antibody; and measuring the label incorporated into the complex.Type: ApplicationFiled: October 14, 2015Publication date: April 21, 2016Applicant: SYSMEX CORPORATIONInventors: Amane HARADA, Katsuhiro MURAKAMI, Maria KIRIYAMA, Keiko YOSHIKAWA, Keiko MIWA
-
Publication number: 20150316532Abstract: An automatic analyzer which realizes stable reagent heating and high dispensing accuracy includes a thermostat bath for controlling a reagent or a reaction solution in reaction cells arranged on a circumference of a reaction disk to have a constant temperature; a first reagent dispensing mechanism dispenses a reagent into the reaction cells; a photometer detects transmitted light or scattered light in the reaction cell; and a disposable reaction container for allowing the sample and the reagent to mix and react with each other. The analyzer also includes a second reagent dispensing mechanism with a reagent heating function which dispenses the reagent into the disposable reaction container; a coagulation time detection section; a reaction container temperature control block; a reagent dispensing syringe which is connected to the second reagent dispensing mechanism; and a fluid temperature control mechanism which controls the temperature of an internal fluid of the reagent dispensing syringe.Type: ApplicationFiled: December 13, 2013Publication date: November 5, 2015Inventors: Akihisa MAKINO, Keiko YOSHIKAWA, Takeshi YOKOKAWA
-
Publication number: 20150316570Abstract: A control section causes one dispensing mechanism of either a reagent dispensing mechanism or a sample dispensing mechanism to first discharge a predetermined amount of a liquid into the reaction container, and then, with respect to the cases where the amount of a liquid to be discharged by the other dispensing mechanism is larger or smaller than the amount of the liquid in the reaction container, causes the other dispensing mechanism to discharge the liquid such that the discharge speed in the case where the amount of the liquid to be discharged is larger is decreased relative to the discharge speed in the case where the amount of the liquid to be discharged is smaller.Type: ApplicationFiled: December 13, 2013Publication date: November 5, 2015Inventors: Keiko YOSHIKAWA, Akihisa MAKINO
-
Publication number: 20150147230Abstract: A configuration of detecting light from the front face of a light source is the best for confirming the variation of a light quantity, but when a plurality of light sources are present, as many detectors for checking a light quantity as the light sources are necessary and the apparatus configuration becomes complex. In the present invention, a detector for checking a light source light quantity is installed in a reaction container transfer mechanism used commonly for a plurality of detection sections, and the light quantities of light sources are checked with the detector.Type: ApplicationFiled: May 24, 2013Publication date: May 28, 2015Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATIONInventors: Keiko Yoshikawa, Akihisa Makino
-
Publication number: 20150104351Abstract: A high-throughput automatic analyzer integrates a biochemical analysis section and a blood coagulation analysis section. The analyzer is capable of achieving a reduction in size, system cost, and lifecycle cost. The automatic analyzer includes: a reaction disk; a first reagent dispensing mechanism that dispenses a reagent to reaction cells on the reaction disk; a photometer that irradiates a reaction solution in the reaction cell with light; a reaction cell cleaning mechanism; a reaction vessel supply unit that supplies a disposable reaction vessel for mixing and reacting a sample and a reagent with each other; a second reagent dispensing mechanism that dispenses a reagent to the disposable reaction vessel; a blood coagulation time measuring section that irradiates a reaction solution in the disposable reaction vessel with light to detect transmitted or scattered light; and a sample dispensing mechanism that dispenses a sample to the reaction cell and the disposable reaction vessel.Type: ApplicationFiled: May 24, 2013Publication date: April 16, 2015Inventors: Akihisa Makino, Hajime Yamazaki, Keiko Yoshikawa, Manabu Ando, Masahiko Iijima
-
Publication number: 20140295488Abstract: A blood cell analyzer comprising a flow cell configured to flow a measurement specimen containing blood cells, a first light source configured to emit light having a first wavelength, a second light source configured to emit light having a second wavelength different from the first wavelength, a first light receiving portion configured to receive first scattered light generated by irradiating the blood cells in the measurement specimen with light from the first light source, a second light receiving portion configured to receive second scattered light generated by irradiating the blood cells in the measurement specimen with light from the second light source, and a control section configured to classify at least white blood cells from the blood cells contained in the measurement specimen, based on a detection signal output from the first light receiving portion and a detection signal output from the second light receiving portion.Type: ApplicationFiled: March 27, 2014Publication date: October 2, 2014Applicant: SYSMEX CORPORATIONInventors: Yusuke KONISHI, Yasuyuki KAWASHIMA, Kazuhiro YAMADA, Keiko YOSHIKAWA
-
Publication number: 20140178908Abstract: A method of competitive immunoassay is provided.Type: ApplicationFiled: December 17, 2013Publication date: June 26, 2014Applicant: SYSMEX CORPORATIONInventors: Keiko YOSHIKAWA, Naoto KOSHIMURA