Abstract: An object is to coat a target position on a substrate with a dense film. In order to achieve the object, while a substrate on which a base containing a coating material is formed is transported, an auxiliary agent is applied to the substrate, and then a main agent containing a coating material is applied to the substrate to react the main agent with the auxiliary agent, so that a portion on the substrate where the base is formed is coated with the coating material.

Abstract: An object is to coat a target position on a substrate with a dense film. In order to achieve the object, while a substrate on which a base containing a coating material is formed is transported, an auxiliary agent is applied to the substrate, and then a main agent containing a coating material is applied to the substrate to react the main agent with the auxiliary agent, so that a portion on the substrate where the base is formed is coated with the coating material.

Abstract: Provided is a method of manufacturing a microneedle array in which an active ingredient is concentrated at a tip while an active ingredient content is guaranteed. In order to achieve the object, a method of manufacturing a microneedle array in which needle-like recessed portions of a mold are filled with a liquid to form one dose of a patch includes determining a filling amount of the liquid from a difference in mass of the mold before and after filling of the liquid, determining a filling state of the liquid in the mold filled with the liquid, sucking the mold in which the filling amount and the filling state of the liquid are determined to be normal from a rear face, and evaporating and drying a solvent of the liquid of the sucked mold.

Abstract: A method of producing a transdermal absorption sheet includes: filling needle-like recessed portions of a mold with a drug solution that is a polymer solution containing a drug; drying the drug solution filling the needle-like recessed portions to form a drug layer containing the drug; supplying a polymer layer forming solution to the mold, the mold provided with a step portion that has a height different from a height of a region in which the needle-like recessed portion is formed in a periphery of the region in which the needle-like recessed portion is formed in a range of equal to or greater than the step portion as seen from above, and then fixing a contact position of the polymer layer forming solution and the mold to the step portion while reducing the polymer layer forming solution; and drying the polymer layer forming solution to form a polymer layer.

Abstract: A method of manufacturing a needle-like array sheet includes supplying a first needle-like array-forming solution consisting of an aqueous solution on a first mold having a first recess; interrupting drying in a wet state and forming a needle-like distal end part; supplying a second needle-like array-forming solution consisting of an aqueous solution on a second mold having a second recess; peeling a sheet part molding product, which is dried and solidified and has a protrusion corresponding to the second recess, after the sheet part molding product is formed; inserting the protrusion of the sheet part molding product into the first recess of the first mold; drying and solidifying the needle-like distal end part and the sheet part molding product after inserting the protrusion, bonding the needle-like distal end part and the protrusion of the sheet part molding product together, and forming a needle-like array sheet having the needle-like array.

Abstract: A method of producing a transdermal absorption sheet including: preparing a mold having needle-like recessed portions including tapered inlet portions; preparing a liquid feeder including an opening portion and a lip land portion; filling the needle-like recessed portions with a solution by feeding the solution to the mold and moving the liquid feeder in a traveling direction while bringing an upstream end of the lip land portion on an upstream side of the liquid feeder in the traveling direction into contact with the mold; and forming needle portions and a sheet portion using a polymer solution. In the filling of the solution, when the upstream end of the lip land portion on the upstream side aligns with an upstream side inlet surface of one of the needle-like recessed portions, the shortest distance from a downstream side inlet surface of the needle-like recessed portion to a surface of the lip land portion on the upstream side is 220 ?m or less.

Abstract: Provided is a method for producing a transdermal absorption sheet capable of suppressing the entrainment of bubbles in a liquid material. A method for producing a transdermal absorption sheet includes a step of preparing a mold having a plurality of needle-like recessed portions, and a step portion which surrounds the plurality of needle-like recessed portions and is higher than a needle-like recessed portion formed surface, and a step of supplying a liquid material for a transdermal absorption sheet from a jetting opening of a filling head to a region surrounded the step portion of the mold, in which the filling head includes a head main body having an inner wall surface defining a supply pipe, and the inner wall surface includes a tapered pipe surface defining a tapered pipe having a diameter gradually increased toward the jetting opening of the head main body.

Abstract: The method includes the steps of: preparing a mold and a liquid filling device; and filling needle-like recessed portions with a liquid medicine by repeating the following: a filling operation in which the liquid medicine is supplied to the mold from the liquid filling device and the needle-like recessed portions are filled with the liquid medicine while a nozzle tip is brought into pressed contact with a surface of the mold; and a moving operation in which a nozzle is relatively moved with respect to the mold while the nozzle tip and the surface of the mold are in contact with each other, wherein the nozzle is held in a Z-axis drive unit configured to vertically move the nozzle while an elastic body is provided in the Z-axis drive unit, while the nozzle tip is brought into pressed contact with the surface of the mold.

Abstract: Provided is a method of manufacturing a microneedle array in which an active ingredient is concentrated at a tip while an active ingredient content is guaranteed. In order to achieve the object, a method of manufacturing a microneedle array in which needle-like recessed portions of a mold are filled with a liquid to form one dose of a patch includes determining a filling amount of the liquid from a difference in mass of the mold before and after filling of the liquid, determining a filling state of the liquid in the mold filled with the liquid, sucking the mold in which the filling amount and the filling state of the liquid are determined to be normal from a rear face, and evaporating and drying a solvent of the liquid of the sucked mold.

Abstract: Provided is a manufacturing method of a sheet having needle-like protrusions capable of individually manufacturing sheets on a mold. The manufacturing method of a sheet having needle-like protrusions includes, for a mold provided with needle-like recesses and an annular groove provided around a region where the needle-like recesses are formed, a first polymer solution supplying step of supplying a first polymer solution, which is to become a first layer, to the needle-like recesses; a second polymer solution supplying step of filling the needle-like recesses and the groove with a second polymer solution by supplying the second polymer solution, which is to become a second layer, to a surface of the mold; a drying step of forming a laminate of the first layer and the second layer by drying the first polymer solution and the second polymer solution; and a peeling step of peeling the laminate away from the mold.

Abstract: A method of manufacturing a needle-like array sheet includes supplying a first needle-like array-forming solution consisting of an aqueous solution on a first mold having a first recess; interrupting drying in a wet state and forming a needle-like distal end part; supplying a second needle-like array-forming solution consisting of an aqueous solution on a second mold having a second recess; peeling a sheet part molding product, which is dried and solidified and has a protrusion corresponding to the second recess, after the sheet part molding product is formed; inserting the protrusion of the sheet part molding product into the first recess of the first mold; drying and solidifying the needle-like distal end part and the sheet part molding product after inserting the protrusion, bonding the needle-like distal end part and the protrusion of the sheet part molding product together, and forming a needle-like array sheet having the needle-like array.

Abstract: The method of producing a transdermal absorption sheet includes: preparing a mold having needle-like recessed portions and an angle of an inlet portion of 120° to 160°, and a liquid feeder including an opening portion and a lip land portion; filling the needle-like recessed portions with a solution by feeding the solution to the mold and moving the liquid feeder while bringing a rear end of a lip land portion on the secondary side of the liquid feeder into contact with the mold; and forming needle portions and a sheet portion using a polymer solution. In the filling of the solution, when the rear end of the lip land portion on the secondary side matches with a secondary side inlet of the needle-like recessed portion, the shortest distance from a primary side inlet of the needle-like recessed portion to a secondary side block is 220 ?m or less.

Abstract: A method of producing a transdermal absorption sheet includes: filling needle-like recessed portions of a mold with a drug solution that is a polymer solution containing a drug; drying the drug solution filling the needle-like recessed portions to form a drug layer containing the drug; supplying a polymer layer forming solution to the mold, the mold provided with a step portion that has a height different from a height of a region in which the needle-like recessed portion is formed in a periphery of the region in which the needle-like recessed portion is formed in a range of equal to or greater than the step portion as seen from above, and then fixing a contact position of the polymer layer forming solution and the mold to the step portion while reducing the polymer layer forming solution; and drying the polymer layer forming solution to form a polymer layer.

Abstract: The manufacturing method of the sheet having the needle-like protruding portions includes: preparing a mold including needle-like recessed portions, and a solution supply device including a slit-like opening formed at a nozzle distal end portion; supplying a solution from the solution supply device to the mold in a state that the nozzle distal end portion is pressed to a front surface of the mold, and filling the solution in the needle-like recessed portions; and moving the solution supply device relatively to the mold in a state that the nozzle distal end portion is brought into contact with the front surface of the mold, and, as a hardness distribution in a thickness direction of the mold, an average value of a Young's modulus at a part within 40 ?m from the front surface of the mold is 1.9 MPa or higher and 100 MPa or lower.

Abstract: The method includes the steps of: preparing a mold and a liquid filling device; and filling needle-like recessed portions with a liquid medicine by repeating the following: a filling operation in which the liquid medicine is supplied to the mold from the liquid filling device and the needle-like recessed portions are filled with the liquid medicine while a nozzle tip is brought into pressed contact with a surface of the mold; and a moving operation in which a nozzle is relatively moved with respect to the mold while the nozzle tip and the surface of the mold are in contact with each other, wherein the nozzle is held in a Z-axis drive unit configured to vertically move the nozzle while an elastic body is provided in the Z-axis drive unit, while the nozzle tip is brought into pressed contact with the surface of the mold.

Abstract: The present invention provides a lithographic printing plate support, comprising an aluminum plate and an anodized film of aluminum formed on the aluminum plate and having micropores extending in the anodized film from a surface of the anodized film opposite from the aluminum plate in a depth direction, wherein each of the micropores has a large-diameter portion having a specific shape and a small-diameter portion having a specific shape and communicating with a bottom of the large-diameter portion; at least a part of an inside of the small-diameter portion is sealed with protrusions made of boehmite; and a ratio of an average height of protrusions made of boehmite inside the large-diameter portion to an average diameter of the large-diameter portion at the surface of the anodized film is up to a predetermined value.

Abstract: A conductive film producing method according to the present invention contains a conductive metal portion forming step of forming a conductive metal portion containing a conductive substance and a binder on a support, and a vapor contact step of bringing the conductive metal portion into contact with a superheated vapor. This method may further contain a smoothing treatment step of smoothing the conductive metal portion, such that the smoothed conductive metal portion is brought into contact with the superheated vapor in the vapor contact step.

Abstract: A presensitized plate bringing about the lithographic printing plate which exhibits a high resistance to scumming and in which formation of bulges causing image dropouts is suppressed is provided with the lithographic printing plate support which includes an aluminum plate and an anodized film of aluminum provided on the aluminum plate, and has a micropore extending in the anodized film in the direction of depth from a film surface opposite with a film surface facing the aluminum plate. The micropore is sealed at least partially on its inside with protrusions made of boehmite, and the protrusions made of boehmite which are located on the anodized film have a mean height of less than 15 nm.

Abstract: A presensitized plate bringing about the lithographic printing plate which exhibits a high resistance to scumming and in which formation of bulges causing image dropouts is suppressed is provided with the lithographic printing plate support which includes an aluminum plate and an anodized film of aluminum provided on the aluminum plate, and has a micropore extending in the anodized film in the direction of depth from a film surface opposite with a film surface facing the aluminum plate. The micropore is sealed at least partially on its inside with protrusions made of boehmite, and the protrusions made of boehmite which are located on the anodized film have a mean height of less than 15 nm.

Abstract: A conductive film producing method according to the present invention contains a conductive metal portion forming step of forming a conductive metal portion containing a conductive substance and a binder on a support, and a vapor contact step of bringing the conductive metal portion into contact with a superheated vapor. This method may further contain a smoothing treatment step of smoothing the conductive metal portion, such that the smoothed conductive metal portion is brought into contact with the superheated vapor in the vapor contact step.