Abstract: The present invention provides an anti-CDH3 humanized antibody having lower immunogenicity, and an anti-CDH3 humanized antibody drug conjugate having the aforementioned anti-CDH3 humanized antibody. The present invention provides a conjugate of an anti-CDH3 humanized antibody and a drug by conjugating a drug having cytotoxicity to an anti-CDH3 humanized antibody having complementarity determining region sequences derived from the heavy chain variable region of an antibody produced by cells having Accession No.

Abstract: It is an object of the present invention to produce an anti-CDH3 humanized antibody having lower immunogenicity, and to provide an anti-CDH3 humanized antibody drug conjugate comprising the aforementioned anti-CDH3 humanized antibody that more efficiently kills cancer cells expressing CDH3. The present invention provides a conjugate of an anti-CDH3 humanized antibody and a drug by conjugating a drug having cytotoxicity to an anti-CDH3 humanized antibody which comprises complementarity determining region sequences derived from the heavy chain variable region of an antibody produced by cells having Accession No.

Abstract: It is an object of the present invention to provide an anti-cadherin antibody having a high internalization capacity and provide an anti-cadherin antibody-drug conjugate that effectively kills cadherin-expressing cancer cells with the use of such antibody. The present invention provides an anti-cadherin antibody which recognizes a cadherin domain 1 (EC1) of cadherin and exhibits a high internalization capacity.

Abstract: It is an object of the present invention to provide a drug conjugate comprising an anti-CDH3 antibody that efficiently kills cancer cells expressing CDH3. According to the present invention, there is provided an immune complex formed by binding an antibody against CDH3 or a fragment thereof having CDH3 binding ability to a chemotherapeutic agent.

Abstract: It is an object of the present invention to provide an anti-cadherin antibody having high antibody-dependent cellular cytotoxicity. The present invention provides an anti-cadherin antibody, which recognizes any one of an upstream region of EC1, a cadherin domain 4 (EC4) and a cadherin domain 5 (EC5), wherein an antibody-dependent cellular cytotoxicity at an antibody concentration of 1 ?g/mL is 30% or more.

Abstract: It is an object of the present invention to provide an anti-cadherin antibody having a high internalization capacity and provide an anti-cadherin antibody-drug conjugate that effectively kills cadherin-expressing cancer cells with the use of such antibody. The present invention provides an anti-cadherin antibody which recognizes a cadherin domain 1 (EC1) of cadherin and exhibits a high internalization capacity.

Abstract: It is an object of the present invention to provide an anti-cadherin antibody having high antibody-dependent cellular cytotoxicity. The present invention provides an anti-cadherin antibody, which recognizes any one of an upstream region of EC1, a cadherin domain 4 (EC4) and a cadherin domain 5 (EC5), wherein an antibody-dependent cellular cytotoxicity at an antibody concentration of 1 ?g/mL is 30% or more.

Abstract: It is an object of the present invention to provide an anti-cadherin antibody having high antibody-dependent cellular cytotoxicity. The present invention provides an anti-cadherin antibody, which recognizes any one of an upstream region of EC1, a cadherin domain 4 (EC4) and a cadherin domain 5 (EC5), wherein an antibody-dependent cellular cytotoxicity at an antibody concentration of 1 ?g/mL is 30% or more.

Abstract: It is an object of the present invention to provide an anti-cadherin antibody having high antibody-dependent cellular cytotoxicity. The present invention provides an anti-cadherin antibody, which recognizes any one of an upstream region of EC1, a cadherin domain 4 (EC4) and a cadherin domain 5 (EC5), wherein an antibody-dependent cellular cytotoxicity at an antibody concentration of 1 ?g/mL is 30% or more.

Abstract: Data is shared between a vehicle mounted navigation device and a vehicle mounted user interface device and among a plurality of vehicle mounted user interface devices. In a first location free display that allows a plurality of users to separately have access to the navigation device, external data obtained from the navigation device or from another location free display and its own user data are saved and managed, and shared with the navigation device and the another location free display. It is possible to utilize the external data not owned by itself or the user data of another person with the navigation device or the another location free display and perform a navigation process in an inner space of the vehicle efficiently.

Abstract: Display devices are connected with a content server mounted inside a vehicle by a wireless communication technology as stipulated in IEEE802.11b. The content server and display devices share common keys (encryption key and corresponding decryption key) acted on by key creation information consisting of information about the vehicle. The content server reads out stored contents according to requests from the display devices. The read contents are then encrypted using the encryption key shared with the display devices and sent to the display devices. The invention can be applied to a wireless communication system consisting of devices which communicate data by wireless communication technology within the vehicle.

Abstract: The present invention is directed to a method for diagnosing large intestinal cancer and/or polyp and a method for observing postoperative course or monitoring recurrence thereof, wherein each method includes detecting cystatin SN protein by use of an anti-cystatin SN antibody. The present invention is able to provide a kit for assaying cystatin SN, which can be used, in a simple manner, in a diagnosis performed prior to conventional barium enema examination and endoscopic examination which impose burdens on patients; as an indicator of metastasis and recurrence; and in the evaluation of therapeutic effects. The present invention provides a method for diagnosing or monitoring large intestinal cancer and/or polyp which can be performed in a simple manner, and thus can allow to design a new regimen rapidly.

Abstract: A lens barrel that configures an imaging apparatus by being detachably attached to an imaging apparatus main body includes a lens barrel in which an imaging lens is formed and a connecting section to the imaging apparatus main body is formed on one end side in an optical axis direction of the imaging lens and a grip section provided on a side surface of the lens barrel and gripped by a camera operator during imaging. The grip section projects from the side surface of the lens barrel further to a side surface of the apparatus main body than an end face on the connecting section side.

Abstract: A map display apparatus is provided to allow a user to easily find out destinations on maps without forcing him/her to perform troublesome operations. An apparatus displays a main map image showing a current position at substantially a center of a screen. The apparatus also disposes a plurality of map images around the main map image in thumbnail format such that each map image corresponds to each direction on the main map image. In this manner, the apparatus provides the user with information about wider area than the main map image by showing him/her the thumbnails , which are disposed around the main map image such that each thumbnail corresponds to each direction on the main map image That allows the user to easily find out destinations on maps without forcing him/her to perform troublesome operations.

Abstract: A lens barrel that configures an imaging apparatus by being detachably attached to an imaging apparatus main body includes a lens barrel in which an imaging lens is formed and a connecting section to the imaging apparatus main body is formed on one end side in an optical axis direction of the imaging lens and a grip section provided on a side surface of the lens barrel and gripped by a camera operator during imaging. The grip section projects from the side surface of the lens barrel further to a side surface of the apparatus main body than an end face on the connecting section side.

Abstract: Data is shared between a vehicle mounted navigation device and a vehicle mounted user interface device and among a plurality of vehicle mounted user interface devices. In a first location free display that allows a plurality of users to separately have access to the navigation device, external data obtained from the navigation device or from another location free display and its own user data are saved and managed, and shared with the navigation device and the another location free display. It is possible to utilize the external data not owned by itself or the user data of another person with the navigation device or the another location free display and perform a navigation process in an inner space of the vehicle efficiently.

Abstract: The present invention allows a user to easily find out destinations on maps without forcing him/her to perform troublesome operations. An apparatus displays a main map image 21 showing a current position at substantially a center of a screen. The apparatus also disposes a plurality of map images 22 through 29 around the main map image 21 in thumbnail format such that each map image 22 through 29 corresponds to each direction on the main map image 21. In this manner, the apparatus provides the user with information about wider area than the main map image 21 by showing him/her the thumbnails 22 through 29, which are disposed around the main map image 21 such that each thumbnail 22 through 29 corresponds to each direction on the main map image 21. That allows the user to easily find out destinations on maps without forcing him/her to perform troublesome operations.

Abstract: Display devices are connected with a content server mounted inside a vehicle by a wireless communication technology as stipulated in IEEE802.11b. The content server and display devices share common keys (encryption key and corresponding decryption key) acted on by key creation information consisting of information about the vehicle. The content server reads out stored contents according to requests from the display devices. The read contents are then encrypted using the encryption key shared with the display devices and sent to the display devices. The invention can be applied to a wireless communication system consisting of devices which communicate data by wireless communication technology within the vehicle.

Abstract: A turntable comprises a guide portion concentric with a rotary shaft for rotary driving an information recording disk and a ring-like centering member for centering the information recording disk by employing a central hole is provided in the information recording disk the centering member being provided so that it can move up and down so that the outer peripheral surface of the guide portion and the inner peripheral surface of the centering member face each other, wherein the centering member applies pressure to the inner periphery of the central hole of the information recording disk during rotation, thereby pressing it against the guide portion. As a result, the guide portion is elastically deformed and the centering accuracy of a disk carried on a turntable is maintained.

Abstract: A strapping machine is disclosed which enables a prolonged life of the driving force supplying means for feeding/tightening a band such as an electric motor to be realized, and which enables maintenance operations such as replacement and adjustment of the parts to be carried out with ease, and whose structure can be rendered simple and inexpensive as a whole, and yet which enables energy saving to be realized. The strapping machine comprising a band feeding/tightening means F adapted to conduct feeding, primary tightening, secondary tightening of a band B to be looped around a periphery of an object to be strapped and the like operation; wherein said band feeding/tightening means F is so constructed as to carry out feeding, primary tightening and secondary tightening of the band B by driving a roller 8 by means of a driving means M2 which is capable of being controlled among rotation, reverse rotation and stopped state.