Abstract: Disclosed herein are methods, systems and therapeutics concerning radiotherapy of microscopic disease based on realtime imaging. The system comprises an intra-corporeal component and an extra-corporeal component. The intra-corporeal component comprises a detector/imaging subunit and a treatment subunit, where both subunits are placed in a cavity of a patient. The extra-corporeal component comprises a detector that is placed outside any cavity of the patient. Through this system, a treatment can be applied to a target tissue in a patient concurrently or within a short period time to signal detections.

Abstract: A CT therapy scanner moves a therapy x-ray source in an arc about a subject. A tumor or lesion is isocentered by the x-ray beam which is a pencil beam. A fan beam, from which the pencil beam is obtained, provides for visualization thereby to ensure that x-ray therapy is accurately delivered. A collimator provides for the conversion of a fan beam to a pencil-fan beam characteristic.