Abstract: Encapsulated nucleic acid nanoparticles of uniformly small particle size are produced by intersecting one or more nucleic acid streams with one or more lipid streams. The encapsulated nucleic acid nanoparticles include a nucleic acid encapsulated within a lipid nanoparticle host. Uniformly small particle sizes are obtained by intersecting an aqueous nucleic acid stream and a stream of lipids in organic solvent at high linear velocities and with total organic solvent concentrations less than 33%.

Abstract: Encapsulated nucleic acid nanoparticles of uniformly small particle size are produced by intersecting one or more nucleic acid streams with one or more lipid streams. The encapsulated nucleic acid nanoparticles include a nucleic acid encapsulated within a lipid nanoparticle host. Uniformly small particle sizes are obtained by intersecting an aqueous nucleic acid stream and a stream of lipids in organic solvent at high linear velocities and with total organic solvent concentrations less than 33%.

Abstract: Sequential circuits with error-detection are provided. They may, for example, be used to replace traditional master-slave flip-flops, e.g., in critical path circuits to detect and initiate correction of late transitions at the input of the sequential. In some embodiments, such sequentials may comprise a transition detector with a time borrowing latch.

Abstract: The disclosed system and method detect and correct register file read path errors that may occur as a result of reducing or eliminating supply voltage guardbands and/or frequency guardbands for a CPU, thereby increasing overall energy efficiency of the system.

Abstract: Encapsulated nucleic acid nanoparticles of uniformly small particle size are produced by intersecting one or more nucleic acid streams with one or more lipid streams. The encapsulated nucleic acid nanoparticles include a nucleic acid encapsulated within a lipid nanoparticle host. Uniformly small particle sizes are obtained by intersecting an aqueous nucleic acid stream and a stream of lipids in organic solvent at high linear velocities and with total organic solvent concentrations less than 33%.

Abstract: Sequential circuits with error-detection are provided. They may, for example, be used to replace traditional master-slave flip-flops, e.g., in critical path circuits to detect and initiate correction of late transitions at the input of the sequential. In some embodiments, such sequentials may comprise a transition detector with a time borrowing latch.

Abstract: Sequential circuits with error-detection are provided. They may, for example, be used to replace traditional master-slave flip-flops, e.g., in critical path circuits to detect and initiate correction of late transitions at the input of the sequential. In some embodiments, such sequentials may comprise a transition detector with a time borrowing latch.

Abstract: The disclosed system and method detect and correct register file read path errors that may occur as a result of reducing or eliminating supply voltage guardbands and/or frequency guardbands for a CPU, thereby increasing overall energy efficiency of the system.

Abstract: The disclosed system and method detect and correct register file read path errors that may occur as a result of reducing or eliminating supply voltage guardbands and/or frequency guardbands for a CPU, thereby increasing overall energy efficiency of the system.

Abstract: Sequential circuits with error-detection are provided. They may, for example, be used to replace traditional master-slave flip-flops, e.g., in critical path circuits to detect and initiate correction of late transitions at the input of the sequential. In some embodiments, such sequentials may comprise a transition detector with a time borrowing latch.

Abstract: An aging monitor circuit that provides a more accurate estimate of aging and/or delay in a circuit and/or circuit path. The aging monitor circuit employs a separate aging path with driving and receiving flip flops (FFs) and a tunable replica circuit (TRC) to enable measurements of single-transition DC-stressed path delay that only propagates through stressed transistors or other circuit element(s). A finite state machine (FSM) in the aging monitor circuit is configured to adjust a frequency of a clock signal output by a digitally controlled oscillator (DCO) in response to an error signal output by the receiving FF. The error signal is generated in response to single-transition DC-stressed path delay; and therefore enables the adjustment of the frequency of the dock signal to correspond to an amount or effect of the delay.

Abstract: Sequential circuits with error-detection are provided. They may, for example, be used to replace traditional master-slave flip-flops, e.g., in critical path circuits to detect and initiate correction of late transitions at the input of the sequential. In some embodiments, such sequentials may comprise a transition detector with a time borrowing latch.

Abstract: Sequential circuits with error-detection are provided. They may, for example, be used to replace traditional master-slave flip-flops, e.g., in critical path circuits to detect and initiate correction of late transitions at the input of the sequential. In some embodiments, such sequentials may comprise a transition detector with a time borrowing latch.

Abstract: The disclosed system and method detect and correct register file read path errors that may occur as a result of reducing or eliminating supply voltage guardbands and/or frequency guardbands for a CPU, thereby increasing overall energy efficiency of the system.

Abstract: An aging monitor circuit that provides a more accurate estimate of aging and/or delay in a circuit and/or circuit path. The aging monitor circuit employs a separate aging path with driving and receiving flip flops (FFs) and a tunable replica circuit (TRC) to enable measurements of single-transition DC-stressed path delay that only propagates through stressed transistors or other circuit element(s). A finite state machine (FSM) in the aging monitor circuit is configured to adjust a frequency of a clock signal output by a digitally controlled oscillator (DCO) in response to an error signal output by the receiving FF. The error signal is generated in response to single transition DC-stressed path delay, and therefore enables the adjustment of the frequency of the clock signal to correspond to an amount or effect of the delay.

Abstract: The instant invention provides for novel lipid nanoparticles and novel lipid nanoparticle components (specifically cationic lipids) that are useful for the delivery of nucleic acids, specifically siRNA, for therapeutic purposes.

Abstract: Some embodiments provide sampling of a data signal output from a path stage using a latch, sampling of the data signal output from the path stage using an edge-triggered flip-flop, comparing a first value output by the latch with a second value output by the edge-triggered flip-flop, and generating an error signal if the first value is different from the second value.

Abstract: Some embodiments provide sampling of a data signal output from a path stage using a latch, sampling of the data signal output from the path stage using an edge-triggered flip-flop, comparing a first value output by the latch with a second value output by the edge-triggered flip-flop, and generating an error signal if the first value is different from the second value.