Patents by Inventor Keith A. Earle

Keith A. Earle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060252762
    Abstract: Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes and other such inhibitors are useful for the treatment of multiple sclerosis.
    Type: Application
    Filed: July 11, 2006
    Publication date: November 9, 2006
    Inventors: Clark Whitehead, Keith Earle, Hector Alila, W. Thompson
  • Publication number: 20060100210
    Abstract: Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes and other such inhibitors are useful for the treatment of scleroderma.
    Type: Application
    Filed: December 15, 2005
    Publication date: May 11, 2006
    Inventors: Clark Whitehead, Keith Earle, Hector Alila, W. Thompson
  • Patent number: 6699894
    Abstract: Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes and other such inhibitors are useful for the treatment of inflammatory bowel disease.
    Type: Grant
    Filed: September 23, 2002
    Date of Patent: March 2, 2004
    Assignee: OSI Pharmaceuticals, Inc.
    Inventors: Keith A. Earle, Hector W. Alila
  • Publication number: 20030176316
    Abstract: Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes and other such inhibitors are useful for the treatment of rheumatoid arthritis.
    Type: Application
    Filed: October 23, 2002
    Publication date: September 18, 2003
    Inventors: Clark M. Whitehead, Keith A. Earle, Hector W. Alila, W. Joseph Thompson
  • Publication number: 20030073711
    Abstract: Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes and other such inhibitors are useful for the treatment of scleroderma.
    Type: Application
    Filed: August 23, 2001
    Publication date: April 17, 2003
    Inventors: Clark M. Whitehead, Keith A. Earle, Hector W. Alila, W. Joseph Thompson
  • Publication number: 20030073740
    Abstract: Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes and other such inhibitors are useful for the treatment of lupus erythematosus.
    Type: Application
    Filed: August 23, 2001
    Publication date: April 17, 2003
    Inventors: Clark M. Whitehead, Keith A. Earle, Hector W. Alila, W. Joseph Thompson
  • Publication number: 20030073741
    Abstract: Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes and other such inhibitors are useful for the treatment of multiple sclerosis.
    Type: Application
    Filed: May 21, 2002
    Publication date: April 17, 2003
    Inventors: Clark M. Whitehead, Keith A. Earle, Hector W. Alila, W. Joseph Thompson
  • Patent number: 6479493
    Abstract: Substituted condensation products of -benzyl-3-indenylacetamides with heterocyclic aldehydes and other such inhibitors are useful for the treatment of type I diabetes.
    Type: Grant
    Filed: August 23, 2001
    Date of Patent: November 12, 2002
    Assignee: Cell Pathways, Inc.
    Inventors: Clark M. Whitehead, Keith A. Earle, Hector W. Alila, W. Joseph Thompson
  • Patent number: 6465494
    Abstract: Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes and other such inhibitors are useful for the treatment of cystic fibrosis.
    Type: Grant
    Filed: August 24, 2001
    Date of Patent: October 15, 2002
    Assignee: Cell Pathways, Inc.
    Inventors: Keith A. Earle, Hector W. Alila, Clark M. Whitehead, W. Joseph Thompson
  • Patent number: 6101015
    Abstract: A variable-coupling quasioptical electron paramagnetic resonance apparatus. In one embodiment, the variable-coupling quasioptical electron paramagnetic resonance apparatus includes a variable coupling quasioptical resonance cavity constructed from two back-to-back Fabry-Perot interferometers. One Fabry-Perot interferometer is formed from two partially reflecting mirrors. The second Fabry-Perot interferometer is an interferometer formed from one of the partially reflecting mirrors and a back mirror. A sample to be studied is placed within the cavity adjacent the partially reflecting mirrors and between one of the partially reflecting mirrors and the back mirror. The relative spacing of the partially reflecting mirrors and the back mirror is adjustable. With this arrangement, the interferometer can be made to act as a single mirror with variable reflectivity, thereby permitting incident radiation reaching the sample to be varied precisely and continuously.
    Type: Grant
    Filed: October 21, 1997
    Date of Patent: August 8, 2000
    Assignee: Northeastern University
    Inventors: David E. Budil, Keith A. Earle, Jack H. Freed, James R. Anderson
  • Patent number: 5902937
    Abstract: An in vitro tissue testing system especially useful for testing blood/tissue interactions. The system includes a tissue holding frame which forms a chamber between two flat pieces of tissue with a spacer plate therebetween. The spacer plate includes a reservoir aperture bordered on both sides by the opposed tissue pieces, and a mechanism for depressing portions of the tissue pieces inwardly into the chamber to propel blood from one side of the chamber to the other. The flow created simulates actual blood flow in a host system. The reservoir aperture may be hourglass shaped with circular end portions and a middle blood passageway. The actuating mechanism may include pistons for alternating contact with the tissue within the confines of the opposite reservoir end portions, thus propelling blood from one end portion to the other. The pistons may be driven by a plurality of eccentric cams on shafts coupled to a common drive motor.
    Type: Grant
    Filed: October 1, 1997
    Date of Patent: May 11, 1999
    Assignee: Baxter International Inc.
    Inventors: David L. Amrani, Danial R. Boggs, Keith A. Earles