Patents by Inventor Keith A. Foster

Keith A. Foster has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Evolution of BoNT peptidases
    Patent number: 12060553
    Abstract: The disclosure provides amino acid sequence variants of Botulinum neurotoxin (BoNT) proteases that cleave (VAMP1, VAMP2, VAMP7, VAMP8, SNAP25, SNAP23, PTEN, etc.) and methods of evolving the same. In some embodiments, proteases described by the disclosure are useful for cleaving proteins found in a cell, that is in an intracellular environment. In some embodiments, proteases described by the disclosure are useful for treating diseases associated with increased or aberrant VAMP7, VAMP8, SNAP23 or PTEN expression or activity, for example, cancer and neurological disorders. Some aspects of this disclosure provide methods for generating BoNT protease variants by continuous directed evolution.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: August 13, 2024
    Assignees: President and Fellows of Harvard College, Ipsen Biopharm Ltd, The Broad Institute, Inc.
    Inventors: Michael S. Packer, Travis R. Blum, David R. Liu, Keith A. Foster, Matthew Brian Beard
  • EVOLUTION OF BONT PEPTIDASES
    Publication number: 20210163924
    Abstract: The disclosure provides amino acid sequence variants of Botulinum neurotoxin (BoNT) proteases that cleave (VAMP1, VAMP2, VAMP7, VAMP8, SNAP25, SNAP23, PTEN, etc.) and methods of evolving the same. In some embodiments, proteases described by the disclosure are useful for cleaving proteins found in a cell, that is in an intracellular environment. In some embodiments, proteases described by the disclosure are useful for treating diseases associated with increased or aberrant VAMP7, VAMP8, SNAP23 or PTEN expression or activity, for example, cancer and neurological disorders. Some aspects of this disclosure provide methods for generating BoNT protease variants by continuous directed evolution.
    Type: Application
    Filed: August 27, 2018
    Publication date: June 3, 2021
    Applicants: President and Fellows of Harvard College, Ipsen Biopharm Ltd
    Inventors: Michael S. Packer, Travis R. Blum, David R. Liu, Keith A. Foster, Matthew Brian Beard