Abstract: Ophthalmic implants, their methods of use and manufacture. The implants may include a transparent optic portion and a peripheral non-optic portion coupled to the optic portion. The transparent optic portion may be made of a transparent optic material adapted to allow visible light to pass therethrough, and the peripheral non-optic portion may be made of a light absorbing material adapted to absorb visible light.

Abstract: Ionized radiation-absorbed, dose sensitive, highly flexible polymeric compositions are provided that exhibits multidirectional changes in refractive index. Also provided are methods of producing a precision multi-directional nanogradient of refractive index in a polymeric composition.

Abstract: Ionized radiation-absorbed, dose sensitive, highly flexible polymeric compositions are provided that exhibits multidirectional changes in refractive index. Also provided are methods of producing a precision multi-directional nanogradient of refractive index in a polymeric composition.

Abstract: Ionized radiation-absorbed, dose sensitive, highly flexible polymeric compositions are provided that exhibits multidirectional changes in refractive index. Also provided are methods of producing a precision multi-directional nanogradient of refractive index in a polymeric composition.

Abstract: Ionized radiation-absorbed, dose sensitive, highly flexible polymeric compositions are provided that exhibits multidirectional changes in refractive index. Also provided are methods of producing a precision multi-directional nanogradient of refractive index in a polymeric composition.

Abstract: Methods of correcting vision for presbyopia, including remodeling a stroma with a laser to create an intracorneal shape, where the corneal shape includes a central region with a thickness that is about 50 microns or less measured from an extension of a shape of a peripheral region of the corneal shape, wherein remodeling a portion of the stroma increases a curvature of a central portion of the anterior surface of the cornea with a central elevation change for near vision.

Abstract: Ionized radiation-absorbed, dose sensitive, highly flexible polymeric compositions are provided that exhibits multidirectional changes in refractive index. Also provided are methods of producing a precision multi-directional nanogradient of refractive index in a polymeric composition.

Abstract: Methods of treating presbyopia of an eye. A corneal inlay is inserted within the cornea such that the central thickness of the corneal inlay is 3 to 7 times a central elevation change.

Abstract: Systems and methods to treat a region of a cornea of an eye having an epithelial layer disposed over a stromal layer. The system comprises a device to map a thickness of the epithelial layer over the region of the cornea to generate a map of epithelial thickness over the region, and a laser to generate a laser beam of an ablative radiation. A movable scan component is coupled to the laser to scan the laser beam over the region. A processor system is coupled to the laser and the movable scan component, and the processor system is configured to arrange pulses of laser beam to ablate the epithelial layer of the region in response to the map of epithelial thickness.

Abstract: Corneal implants that have an implant body comprising manufactured corneal tissue. Methods of manufacturing corneal implant that include manufacturing a volume of corneal tissue. Corneal implants that have an implant body made from cornea tissue removed from a living subject.

Abstract: Methods of correcting vision for presbyopia, including remodeling a stroma with a laser to create an intracorneal shape, where the corneal shape includes a central region with a thickness that is about 50 microns or less measured from an extension of a shape of a peripheral region of the corneal shape, wherein remodeling a portion of the stroma increases a curvature of a central portion of the anterior surface of the cornea with a central elevation change for near vision.

Abstract: The present invention provides improved methods and systems for laser beam positioning, shape profile, size profile, drift, and/or deflection calibration using an image capture device, such as a microscope camera, for enhanced calibration accuracy and precision. The methods and systems are particularly suited for iris calibration and hysteresis measurement of a variable diameter aperture. One method for calibrating laser pulses from a laser eye surgery system using an image capture device comprises imaging a known object with an image capture device. A pulsed laser beam is directed onto a calibration surface so as to leave a mark on the calibration surface. The mark on the calibration surface is then imaged with the image capture device. The laser eye surgery system is calibrated by comparing the image of the mark on the calibration surface to the image of the known object.

Abstract: The present invention provides improved methods and systems for laser beam positioning, shape profile, size profile, drift, and/or deflection calibration using an image capture device, such as a microscope camera, for enhanced calibration accuracy and precision. The methods and systems are particularly suited for iris calibration and hysteresis measurement of a variable diameter aperture. One method for calibrating laser pulses from a laser eye surgery system using an image capture device comprises imaging a known object with an image capture device. A pulsed laser beam is directed onto a calibration surface so as to leave a mark on the calibration surface. The mark on the calibration surface is then imaged with the image capture device. The laser eye surgery system is calibrated by comparing the image of the mark on the calibration surface to the image of the known object.

Abstract: Methods of correcting vision for presbyopia, including remodeling a stroma with a laser to create an intracorneal shape, where the corneal shape includes a central region with a thickness that is about 50 microns or less measured from an extension of a shape of a peripheral region of the corneal shape, wherein remodeling a portion of the stroma increases a curvature of a central portion of the anterior surface of the cornea with a central elevation change for near vision.

Abstract: Systems and methods to treat a region of a cornea of an eye having an epithelial layer disposed over a stromal layer. The system comprises a device to map a thickness of the epithelial layer over the region of the cornea to generate a map of epithelial thickness over the region, and a laser to generate a laser beam of an ablative radiation. A movable scan component is coupled to the laser to scan the laser beam over the region. A processor system is coupled to the laser and the movable scan component, and the processor system is configured to arrange pulses of laser beam to ablate the epithelial layer of the region in response to the map of epithelial thickness.

Abstract: Systems and methods to treat a region of a cornea of an eye having an epithelial layer disposed over a stromal layer. The system comprises a device to map a thickness of the epithelial layer over the region of the cornea to generate a map of epithelial thickness over the region, and a laser to generate a laser beam of an ablative radiation. A movable scan component is coupled to the laser to scan the laser beam over the region. A processor system is coupled to the laser and the movable scan component, and the processor system is configured to arrange pulses of laser beam to ablate the epithelial layer of the region in response to the map of epithelial thickness.

Abstract: Systems and methods to treat a region of a cornea of an eye having an epithelial layer disposed over a stromal layer. The system comprises a device to map a thickness of the epithelial layer over the region of the cornea to generate a map of epithelial thickness over the region, and a laser to generate a laser beam of an ablative radiation. A movable scan component is coupled to the laser to scan the laser beam over the region. A processor system is coupled to the laser and the movable scan component, and the processor system is configured to arrange pulses of laser beam to ablate the epithelial layer of the region in response to the map of epithelial thickness.

Abstract: Systems and methods to treat a region of a cornea of an eye having an epithelial layer disposed over a stromal layer. The system comprises a device to map a thickness of the epithelial layer over the region of the cornea to generate a map of epithelial thickness over the region, and a laser to generate a laser beam of an ablative radiation. A movable scan component is coupled to the laser to scan the laser beam over the region. A processor system is coupled to the laser and the movable scan component, and the processor system is configured to arrange pulses of laser beam to ablate the epithelial layer of the region in response to the map of epithelial thickness.

Abstract: Corneal implant inserters and methods of use. The inserters are adapted such that they can be used to deliver corneal inlays into corneal pockets.

Abstract: Methods of lenticule extraction to correct for presbyopia that account for epithelial remodeling.